Serum biomarkers for the prediction of hepatocellular carcinoma

Autores
Debes, José D.; Romagnoli, Pablo Alberto; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; Boonstra, André
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.
Fil: Debes, José D.. Erasmus MC Rotterdam; Países Bajos. University of Minnesota; Estados Unidos
Fil: Romagnoli, Pablo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Instituto de Investigación Médica Mercedes y Martín Ferreyra. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina
Fil: Prieto, Jhon. Centro de Enfermedades Hepáticas y Digestivas; Colombia
Fil: Arrese, Marco. Pontificia Universidad Católica de Chile; Chile
Fil: Mattos, Angelo Z.. Universidade Federal de Ciencias Da Saúde de Porto Alegre; Brasil
Fil: Boonstra, André. Erasmus MC Rotterdam; Países Bajos
Materia
BIOMARKER
CYTOKINES
HEPATOCELLULAR CARCINOMA
MICRORNA
TUMOR MARKER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168642
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Serum biomarkers for the prediction of hepatocellular carcinomaDebes, José D.Romagnoli, Pablo AlbertoPrieto, JhonArrese, MarcoMattos, Angelo Z.Boonstra, AndréBIOMARKERCYTOKINESHEPATOCELLULAR CARCINOMAMICRORNATUMOR MARKERhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.Fil: Debes, José D.. Erasmus MC Rotterdam; Países Bajos. University of Minnesota; Estados UnidosFil: Romagnoli, Pablo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Instituto de Investigación Médica Mercedes y Martín Ferreyra. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; ArgentinaFil: Prieto, Jhon. Centro de Enfermedades Hepáticas y Digestivas; ColombiaFil: Arrese, Marco. Pontificia Universidad Católica de Chile; ChileFil: Mattos, Angelo Z.. Universidade Federal de Ciencias Da Saúde de Porto Alegre; BrasilFil: Boonstra, André. Erasmus MC Rotterdam; Países BajosMultidisciplinary Digital Publishing Institute2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168642Debes, José D.; Romagnoli, Pablo Alberto; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; et al.; Serum biomarkers for the prediction of hepatocellular carcinoma; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 4-2021; 1-132072-6694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13071681info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/7/1681info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:29:52Zoai:ri.conicet.gov.ar:11336/168642instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:29:52.499CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum biomarkers for the prediction of hepatocellular carcinoma
title Serum biomarkers for the prediction of hepatocellular carcinoma
spellingShingle Serum biomarkers for the prediction of hepatocellular carcinoma
Debes, José D.
BIOMARKER
CYTOKINES
HEPATOCELLULAR CARCINOMA
MICRORNA
TUMOR MARKER
title_short Serum biomarkers for the prediction of hepatocellular carcinoma
title_full Serum biomarkers for the prediction of hepatocellular carcinoma
title_fullStr Serum biomarkers for the prediction of hepatocellular carcinoma
title_full_unstemmed Serum biomarkers for the prediction of hepatocellular carcinoma
title_sort Serum biomarkers for the prediction of hepatocellular carcinoma
dc.creator.none.fl_str_mv Debes, José D.
Romagnoli, Pablo Alberto
Prieto, Jhon
Arrese, Marco
Mattos, Angelo Z.
Boonstra, André
author Debes, José D.
author_facet Debes, José D.
Romagnoli, Pablo Alberto
Prieto, Jhon
Arrese, Marco
Mattos, Angelo Z.
Boonstra, André
author_role author
author2 Romagnoli, Pablo Alberto
Prieto, Jhon
Arrese, Marco
Mattos, Angelo Z.
Boonstra, André
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BIOMARKER
CYTOKINES
HEPATOCELLULAR CARCINOMA
MICRORNA
TUMOR MARKER
topic BIOMARKER
CYTOKINES
HEPATOCELLULAR CARCINOMA
MICRORNA
TUMOR MARKER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.
Fil: Debes, José D.. Erasmus MC Rotterdam; Países Bajos. University of Minnesota; Estados Unidos
Fil: Romagnoli, Pablo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa | Instituto de Investigación Médica Mercedes y Martín Ferreyra. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Grupo Vinculado Centro de Investigación en Medicina Traslacional Severo R. Amuchástegui - Cimetsa; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina
Fil: Prieto, Jhon. Centro de Enfermedades Hepáticas y Digestivas; Colombia
Fil: Arrese, Marco. Pontificia Universidad Católica de Chile; Chile
Fil: Mattos, Angelo Z.. Universidade Federal de Ciencias Da Saúde de Porto Alegre; Brasil
Fil: Boonstra, André. Erasmus MC Rotterdam; Países Bajos
description Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168642
Debes, José D.; Romagnoli, Pablo Alberto; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; et al.; Serum biomarkers for the prediction of hepatocellular carcinoma; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 4-2021; 1-13
2072-6694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168642
identifier_str_mv Debes, José D.; Romagnoli, Pablo Alberto; Prieto, Jhon; Arrese, Marco; Mattos, Angelo Z.; et al.; Serum biomarkers for the prediction of hepatocellular carcinoma; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 4-2021; 1-13
2072-6694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13071681
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/7/1681
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606655266193408
score 13.001348

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