The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates

Autores
Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Turjan, J; Yanbo, K. Z.; Capek, P.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors.
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Turjan, J. Slovak Academy of Sciences; Eslovaquia
Fil: Yanbo, K. Z.. University of Hong Kong; Hong Kong
Fil: Capek, P.. Slovak Academy of Sciences; Eslovaquia
Materia
4ome-Glucuronoxylan Sulfates
Antiviral Activity
Herpes Simplex Virus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52610
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfatesPujol, Carlos AlbertoDamonte, Elsa BeatrizTurjan, JYanbo, K. Z.Capek, P.4ome-Glucuronoxylan SulfatesAntiviral ActivityHerpes Simplex Virushttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors.Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Turjan, J. Slovak Academy of Sciences; EslovaquiaFil: Yanbo, K. Z.. University of Hong Kong; Hong KongFil: Capek, P.. Slovak Academy of Sciences; EslovaquiaElsevier Science2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52610Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Turjan, J; Yanbo, K. Z.; Capek, P.; The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates; Elsevier Science; International Journal of Biological Macromolecules; 87; 6-2016; 195-2000141-8130CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2016.02.048info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813016301799info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:38:46Zoai:ri.conicet.gov.ar:11336/52610instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:38:46.782CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
title The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
spellingShingle The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
Pujol, Carlos Alberto
4ome-Glucuronoxylan Sulfates
Antiviral Activity
Herpes Simplex Virus
title_short The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
title_full The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
title_fullStr The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
title_full_unstemmed The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
title_sort The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
dc.creator.none.fl_str_mv Pujol, Carlos Alberto
Damonte, Elsa Beatriz
Turjan, J
Yanbo, K. Z.
Capek, P.
author Pujol, Carlos Alberto
author_facet Pujol, Carlos Alberto
Damonte, Elsa Beatriz
Turjan, J
Yanbo, K. Z.
Capek, P.
author_role author
author2 Damonte, Elsa Beatriz
Turjan, J
Yanbo, K. Z.
Capek, P.
author2_role author
author
author
author
dc.subject.none.fl_str_mv 4ome-Glucuronoxylan Sulfates
Antiviral Activity
Herpes Simplex Virus
topic 4ome-Glucuronoxylan Sulfates
Antiviral Activity
Herpes Simplex Virus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors.
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Turjan, J. Slovak Academy of Sciences; Eslovaquia
Fil: Yanbo, K. Z.. University of Hong Kong; Hong Kong
Fil: Capek, P.. Slovak Academy of Sciences; Eslovaquia
description Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52610
Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Turjan, J; Yanbo, K. Z.; Capek, P.; The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates; Elsevier Science; International Journal of Biological Macromolecules; 87; 6-2016; 195-200
0141-8130
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52610
identifier_str_mv Pujol, Carlos Alberto; Damonte, Elsa Beatriz; Turjan, J; Yanbo, K. Z.; Capek, P.; The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates; Elsevier Science; International Journal of Biological Macromolecules; 87; 6-2016; 195-200
0141-8130
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2016.02.048
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0141813016301799
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082868627898368
score 13.22299

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