Metabolic pathways and intracellular trafficking of gangliosides

Autores
Daniotti, Jose Luis; Iglesias Bartolome, Ramiro
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gangliosides constitute a large and heterogeneous family ofacidic glycosphingolipids that contain one or more sialic acid residuesand are expressed in nearly all vertebrate cells. Their denovo synthesis starts at the endoplasmic reticulum and is continuedby a combination of glycosyltransferase activities at the Golgicomplex, followed by vesicular delivery to the plasma membrane.At the cell surface, gangliosides participate in a variety of physiologicalas well as pathological processes. The cloning of genes formost of the glycosyltransferases responsible for ganglioside biosynthesishas produced a better understanding of the cellular andmolecular basis of the ganglioside metabolism. In addition, theability to delete groups of glycosphingolipid structures in micehas been enormously important in determining their physiologicalroles. Recently, a number of enzymes for ganglioside anabolismand catabolism have been shown to be associated with the plasmamembrane, which might contribute to modulate local glycolipidcomposition, and consequently, the cell function.
Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Iglesias Bartolome, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Materia
Gangliosides
Sphingolipids
Intracellular trafficking
Glycosyltransferases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229680
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Metabolic pathways and intracellular trafficking of gangliosidesDaniotti, Jose LuisIglesias Bartolome, RamiroGangliosidesSphingolipidsIntracellular traffickingGlycosyltransferaseshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gangliosides constitute a large and heterogeneous family ofacidic glycosphingolipids that contain one or more sialic acid residuesand are expressed in nearly all vertebrate cells. Their denovo synthesis starts at the endoplasmic reticulum and is continuedby a combination of glycosyltransferase activities at the Golgicomplex, followed by vesicular delivery to the plasma membrane.At the cell surface, gangliosides participate in a variety of physiologicalas well as pathological processes. The cloning of genes formost of the glycosyltransferases responsible for ganglioside biosynthesishas produced a better understanding of the cellular andmolecular basis of the ganglioside metabolism. In addition, theability to delete groups of glycosphingolipid structures in micehas been enormously important in determining their physiologicalroles. Recently, a number of enzymes for ganglioside anabolismand catabolism have been shown to be associated with the plasmamembrane, which might contribute to modulate local glycolipidcomposition, and consequently, the cell function.Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Iglesias Bartolome, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaJohn Wiley & Sons2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229680Daniotti, Jose Luis; Iglesias Bartolome, Ramiro; Metabolic pathways and intracellular trafficking of gangliosides; John Wiley & Sons; IUBMB Life; 63; 7; 3-2011; 513-5201521-65431521-6551CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/iub.477info:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.477info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:43Zoai:ri.conicet.gov.ar:11336/229680instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:43.343CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metabolic pathways and intracellular trafficking of gangliosides
title Metabolic pathways and intracellular trafficking of gangliosides
spellingShingle Metabolic pathways and intracellular trafficking of gangliosides
Daniotti, Jose Luis
Gangliosides
Sphingolipids
Intracellular trafficking
Glycosyltransferases
title_short Metabolic pathways and intracellular trafficking of gangliosides
title_full Metabolic pathways and intracellular trafficking of gangliosides
title_fullStr Metabolic pathways and intracellular trafficking of gangliosides
title_full_unstemmed Metabolic pathways and intracellular trafficking of gangliosides
title_sort Metabolic pathways and intracellular trafficking of gangliosides
dc.creator.none.fl_str_mv Daniotti, Jose Luis
Iglesias Bartolome, Ramiro
author Daniotti, Jose Luis
author_facet Daniotti, Jose Luis
Iglesias Bartolome, Ramiro
author_role author
author2 Iglesias Bartolome, Ramiro
author2_role author
dc.subject.none.fl_str_mv Gangliosides
Sphingolipids
Intracellular trafficking
Glycosyltransferases
topic Gangliosides
Sphingolipids
Intracellular trafficking
Glycosyltransferases
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gangliosides constitute a large and heterogeneous family ofacidic glycosphingolipids that contain one or more sialic acid residuesand are expressed in nearly all vertebrate cells. Their denovo synthesis starts at the endoplasmic reticulum and is continuedby a combination of glycosyltransferase activities at the Golgicomplex, followed by vesicular delivery to the plasma membrane.At the cell surface, gangliosides participate in a variety of physiologicalas well as pathological processes. The cloning of genes formost of the glycosyltransferases responsible for ganglioside biosynthesishas produced a better understanding of the cellular andmolecular basis of the ganglioside metabolism. In addition, theability to delete groups of glycosphingolipid structures in micehas been enormously important in determining their physiologicalroles. Recently, a number of enzymes for ganglioside anabolismand catabolism have been shown to be associated with the plasmamembrane, which might contribute to modulate local glycolipidcomposition, and consequently, the cell function.
Fil: Daniotti, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Iglesias Bartolome, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
description Gangliosides constitute a large and heterogeneous family ofacidic glycosphingolipids that contain one or more sialic acid residuesand are expressed in nearly all vertebrate cells. Their denovo synthesis starts at the endoplasmic reticulum and is continuedby a combination of glycosyltransferase activities at the Golgicomplex, followed by vesicular delivery to the plasma membrane.At the cell surface, gangliosides participate in a variety of physiologicalas well as pathological processes. The cloning of genes formost of the glycosyltransferases responsible for ganglioside biosynthesishas produced a better understanding of the cellular andmolecular basis of the ganglioside metabolism. In addition, theability to delete groups of glycosphingolipid structures in micehas been enormously important in determining their physiologicalroles. Recently, a number of enzymes for ganglioside anabolismand catabolism have been shown to be associated with the plasmamembrane, which might contribute to modulate local glycolipidcomposition, and consequently, the cell function.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229680
Daniotti, Jose Luis; Iglesias Bartolome, Ramiro; Metabolic pathways and intracellular trafficking of gangliosides; John Wiley & Sons; IUBMB Life; 63; 7; 3-2011; 513-520
1521-6543
1521-6551
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229680
identifier_str_mv Daniotti, Jose Luis; Iglesias Bartolome, Ramiro; Metabolic pathways and intracellular trafficking of gangliosides; John Wiley & Sons; IUBMB Life; 63; 7; 3-2011; 513-520
1521-6543
1521-6551
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/iub.477
info:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.477
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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