Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways

Autores
Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez Millán, María Inés
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.
Fil: Cheung, Leonard Y. M.. University of Michigan; Estados Unidos
Fil: Davis, Shannon W.. University of South Carolina; Estados Unidos
Fil: Brinkmeier, Michelle L.. University of Michigan; Estados Unidos
Fil: Camper, Sally A.. University of Michigan; Estados Unidos
Fil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
Emt
Prop1
Sox2
Pituitary
Stem Cells
Extracellular Matrix
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47759
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathwaysCheung, Leonard Y. M.Davis, Shannon W.Brinkmeier, Michelle L.Camper, Sally A.Pérez Millán, María InésEmtProp1Sox2PituitaryStem CellsExtracellular Matrixhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.Fil: Cheung, Leonard Y. M.. University of Michigan; Estados UnidosFil: Davis, Shannon W.. University of South Carolina; Estados UnidosFil: Brinkmeier, Michelle L.. University of Michigan; Estados UnidosFil: Camper, Sally A.. University of Michigan; Estados UnidosFil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaElsevier Ireland2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47759Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez Millán, María Inés; Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways; Elsevier Ireland; Molecular and Cellular Endocrinology; 445; 4-2017; 14-260303-72071872-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2016.09.016info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720716303811info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590650/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:39Zoai:ri.conicet.gov.ar:11336/47759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:39.783CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
title Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
spellingShingle Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
Cheung, Leonard Y. M.
Emt
Prop1
Sox2
Pituitary
Stem Cells
Extracellular Matrix
title_short Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
title_full Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
title_fullStr Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
title_full_unstemmed Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
title_sort Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways
dc.creator.none.fl_str_mv Cheung, Leonard Y. M.
Davis, Shannon W.
Brinkmeier, Michelle L.
Camper, Sally A.
Pérez Millán, María Inés
author Cheung, Leonard Y. M.
author_facet Cheung, Leonard Y. M.
Davis, Shannon W.
Brinkmeier, Michelle L.
Camper, Sally A.
Pérez Millán, María Inés
author_role author
author2 Davis, Shannon W.
Brinkmeier, Michelle L.
Camper, Sally A.
Pérez Millán, María Inés
author2_role author
author
author
author
dc.subject.none.fl_str_mv Emt
Prop1
Sox2
Pituitary
Stem Cells
Extracellular Matrix
topic Emt
Prop1
Sox2
Pituitary
Stem Cells
Extracellular Matrix
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.
Fil: Cheung, Leonard Y. M.. University of Michigan; Estados Unidos
Fil: Davis, Shannon W.. University of South Carolina; Estados Unidos
Fil: Brinkmeier, Michelle L.. University of Michigan; Estados Unidos
Fil: Camper, Sally A.. University of Michigan; Estados Unidos
Fil: Pérez Millán, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47759
Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez Millán, María Inés; Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways; Elsevier Ireland; Molecular and Cellular Endocrinology; 445; 4-2017; 14-26
0303-7207
1872-8057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47759
identifier_str_mv Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez Millán, María Inés; Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways; Elsevier Ireland; Molecular and Cellular Endocrinology; 445; 4-2017; 14-26
0303-7207
1872-8057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2016.09.016
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720716303811
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590650/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269767618002944
score 13.13397

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