What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Autores
Bernardi, Yanel Elina; Strobl Mazulla, Pablo Hernan
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epithelial plasticity involved the terminal and transitional stages that occur during epithelial- to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development that have been coopted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the latest findings of the cellular and molecular basis of the less characterized process of MET during embryonic development, with special attention to the role of microRNAs. Although we take in consideration the necessity of being cautious when extrapolating the obtained evidence, we propose some commonalities between early embryonic development and cancer progression that can shed light into our current understanding of this complex event and might aid in the design of specific therapeutic approaches.
Fil: Bernardi, Yanel Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Strobl Mazulla, Pablo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Materia
EMT
MET
Epigenetics
microRNAs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164982
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progressionBernardi, Yanel ElinaStrobl Mazulla, Pablo HernanEMTMETEpigeneticsmicroRNAshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Epithelial plasticity involved the terminal and transitional stages that occur during epithelial- to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development that have been coopted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the latest findings of the cellular and molecular basis of the less characterized process of MET during embryonic development, with special attention to the role of microRNAs. Although we take in consideration the necessity of being cautious when extrapolating the obtained evidence, we propose some commonalities between early embryonic development and cancer progression that can shed light into our current understanding of this complex event and might aid in the design of specific therapeutic approaches.Fil: Bernardi, Yanel Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Strobl Mazulla, Pablo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaJournal of the Serbian Chemical Society2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164982Bernardi, Yanel Elina; Strobl Mazulla, Pablo Hernan; What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression; Journal of the Serbian Chemical Society; Biochemical Journal; 478; 9; 5-2021; 1809-18250264-6021CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1042/BCJ20210083info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/biochemj/article-abstract/478/9/1809/228650/What-we-can-learn-from-embryos-to-understand-the?redirectedFrom=fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:45Zoai:ri.conicet.gov.ar:11336/164982instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:45.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
title What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
spellingShingle What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
Bernardi, Yanel Elina
EMT
MET
Epigenetics
microRNAs
title_short What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
title_full What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
title_fullStr What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
title_full_unstemmed What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
title_sort What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
dc.creator.none.fl_str_mv Bernardi, Yanel Elina
Strobl Mazulla, Pablo Hernan
author Bernardi, Yanel Elina
author_facet Bernardi, Yanel Elina
Strobl Mazulla, Pablo Hernan
author_role author
author2 Strobl Mazulla, Pablo Hernan
author2_role author
dc.subject.none.fl_str_mv EMT
MET
Epigenetics
microRNAs
topic EMT
MET
Epigenetics
microRNAs
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Epithelial plasticity involved the terminal and transitional stages that occur during epithelial- to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development that have been coopted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the latest findings of the cellular and molecular basis of the less characterized process of MET during embryonic development, with special attention to the role of microRNAs. Although we take in consideration the necessity of being cautious when extrapolating the obtained evidence, we propose some commonalities between early embryonic development and cancer progression that can shed light into our current understanding of this complex event and might aid in the design of specific therapeutic approaches.
Fil: Bernardi, Yanel Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Strobl Mazulla, Pablo Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
description Epithelial plasticity involved the terminal and transitional stages that occur during epithelial- to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET), both are essential at different stages of early embryonic development that have been coopted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the latest findings of the cellular and molecular basis of the less characterized process of MET during embryonic development, with special attention to the role of microRNAs. Although we take in consideration the necessity of being cautious when extrapolating the obtained evidence, we propose some commonalities between early embryonic development and cancer progression that can shed light into our current understanding of this complex event and might aid in the design of specific therapeutic approaches.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164982
Bernardi, Yanel Elina; Strobl Mazulla, Pablo Hernan; What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression; Journal of the Serbian Chemical Society; Biochemical Journal; 478; 9; 5-2021; 1809-1825
0264-6021
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164982
identifier_str_mv Bernardi, Yanel Elina; Strobl Mazulla, Pablo Hernan; What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression; Journal of the Serbian Chemical Society; Biochemical Journal; 478; 9; 5-2021; 1809-1825
0264-6021
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1042/BCJ20210083
info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/biochemj/article-abstract/478/9/1809/228650/What-we-can-learn-from-embryos-to-understand-the?redirectedFrom=fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of the Serbian Chemical Society
publisher.none.fl_str_mv Journal of the Serbian Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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