Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Autores
Quinto Sanchez, Mirsha Emmanuel; Muñoz Muñoz, Francesc; Gomez Valdes, Jorge; Cintas, Celia; Navarro, Jose Pablo; Silva de Cerqueira, Caio Cesar; Paschetta, Carolina Andrea; de Azevedo, Soledad; Ramallo, Virginia; Acuña Alonzo, Victor; Adhikari, Kaustubh; Fuentes Guajardo, MacArena; Hünemeier, Tábita; Everardo, Paola; De Avila, Francisco; Jaramillo, Claudia; Arias, Williams; Gallo, Carla; Poletti, Giovani; Bedoya Berrío, Gabriel; Bortolini, Maria Catira; Canizales Quinteros, Samuel; Rothhammer, Francisco; Rosique, Javier; Ruiz-Linares, Andres; González José, Rolando
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Muñoz-Muñoz, Francesc. Universidad Nacional Autónoma de México; México
Fil: Gomez-Valdes, Jorge. Universitat Autònoma de Barcelona; España
Fil: Cintas, Celia. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Navarro, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Cerqueira, Caio Cesar Silva De. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paschetta, Carolina Andrea. Equipe de Perícias Criminalísticas de Ourinhos;
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Acuña-Alonzo, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido
Fil: Fuentes-Guajardo, MacArena. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Hünemeier, Tábita. Colegio Universitario de Londres; Reino Unido
Fil: Everardo, Paola. Universidad de Tarapaca de Arica; Chile
Fil: De Avila, Francisco. Colegio Universitario de Londres; Reino Unido
Fil: Jaramillo, Claudia. Universidade de Sao Paulo; Brasil
Fil: Arias, Williams. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Gallo, Carla. Universidad Nacional Autónoma de México; México
Fil: Poletti, Giovani. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria Catira. Universidad de Antioquia; Colombia
Fil: Canizales-Quinteros, Samuel. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad Peruana Cayetano Heredia; Perú
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Ruiz-Linares, Andres. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Materia
HUMAN FACE
FLUCTUATING ASYMMETRY
GEOMETRIC MORPHOMETRIC
LATIN AMERICANS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95265
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/95265
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network_name_str CONICET Digital (CONICET)
spelling Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human faceQuinto Sanchez, Mirsha EmmanuelMuñoz Muñoz, FrancescGomez Valdes, JorgeCintas, CeliaNavarro, Jose PabloSilva de Cerqueira, Caio CesarPaschetta, Carolina Andreade Azevedo, SoledadRamallo, VirginiaAcuña Alonzo, VictorAdhikari, KaustubhFuentes Guajardo, MacArenaHünemeier, TábitaEverardo, PaolaDe Avila, FranciscoJaramillo, ClaudiaArias, WilliamsGallo, CarlaPoletti, GiovaniBedoya Berrío, GabrielBortolini, Maria CatiraCanizales Quinteros, SamuelRothhammer, FranciscoRosique, JavierRuiz-Linares, AndresGonzález José, RolandoHUMAN FACEFLUCTUATING ASYMMETRYGEOMETRIC MORPHOMETRICLATIN AMERICANShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Muñoz-Muñoz, Francesc. Universidad Nacional Autónoma de México; MéxicoFil: Gomez-Valdes, Jorge. Universitat Autònoma de Barcelona; EspañaFil: Cintas, Celia. Instituto Nacional de Antropologia E Historia, Mexico; MéxicoFil: Navarro, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Cerqueira, Caio Cesar Silva De. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paschetta, Carolina Andrea. Equipe de Perícias Criminalísticas de Ourinhos;Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Acuña-Alonzo, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino UnidoFil: Fuentes-Guajardo, MacArena. Instituto Nacional de Antropologia E Historia, Mexico; MéxicoFil: Hünemeier, Tábita. Colegio Universitario de Londres; Reino UnidoFil: Everardo, Paola. Universidad de Tarapaca de Arica; ChileFil: De Avila, Francisco. Colegio Universitario de Londres; Reino UnidoFil: Jaramillo, Claudia. Universidade de Sao Paulo; BrasilFil: Arias, Williams. Instituto Nacional de Antropologia E Historia, Mexico; MéxicoFil: Gallo, Carla. Universidad Nacional Autónoma de México; MéxicoFil: Poletti, Giovani. Instituto Nacional de Antropologia E Historia, Mexico; MéxicoFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Bortolini, Maria Catira. Universidad de Antioquia; ColombiaFil: Canizales-Quinteros, Samuel. Universidad Peruana Cayetano Heredia; PerúFil: Rothhammer, Francisco. Universidad Peruana Cayetano Heredia; PerúFil: Rosique, Javier. Universidad de Antioquia; ColombiaFil: Ruiz-Linares, Andres. Universidade Federal do Rio Grande do Sul; BrasilFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaNature Publishing Group2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95265Quinto Sanchez, Mirsha Emmanuel; Muñoz Muñoz, Francesc; Gomez Valdes, Jorge; Cintas, Celia; Navarro, Jose Pablo; et al.; Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-152045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-19324-yinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-19324-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:19Zoai:ri.conicet.gov.ar:11336/95265instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:19.566CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
title Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
spellingShingle Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
Quinto Sanchez, Mirsha Emmanuel
HUMAN FACE
FLUCTUATING ASYMMETRY
GEOMETRIC MORPHOMETRIC
LATIN AMERICANS
title_short Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
title_full Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
title_fullStr Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
title_full_unstemmed Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
title_sort Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
dc.creator.none.fl_str_mv Quinto Sanchez, Mirsha Emmanuel
Muñoz Muñoz, Francesc
Gomez Valdes, Jorge
Cintas, Celia
Navarro, Jose Pablo
Silva de Cerqueira, Caio Cesar
Paschetta, Carolina Andrea
de Azevedo, Soledad
Ramallo, Virginia
Acuña Alonzo, Victor
Adhikari, Kaustubh
Fuentes Guajardo, MacArena
Hünemeier, Tábita
Everardo, Paola
De Avila, Francisco
Jaramillo, Claudia
Arias, Williams
Gallo, Carla
Poletti, Giovani
Bedoya Berrío, Gabriel
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Rosique, Javier
Ruiz-Linares, Andres
González José, Rolando
author Quinto Sanchez, Mirsha Emmanuel
author_facet Quinto Sanchez, Mirsha Emmanuel
Muñoz Muñoz, Francesc
Gomez Valdes, Jorge
Cintas, Celia
Navarro, Jose Pablo
Silva de Cerqueira, Caio Cesar
Paschetta, Carolina Andrea
de Azevedo, Soledad
Ramallo, Virginia
Acuña Alonzo, Victor
Adhikari, Kaustubh
Fuentes Guajardo, MacArena
Hünemeier, Tábita
Everardo, Paola
De Avila, Francisco
Jaramillo, Claudia
Arias, Williams
Gallo, Carla
Poletti, Giovani
Bedoya Berrío, Gabriel
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Rosique, Javier
Ruiz-Linares, Andres
González José, Rolando
author_role author
author2 Muñoz Muñoz, Francesc
Gomez Valdes, Jorge
Cintas, Celia
Navarro, Jose Pablo
Silva de Cerqueira, Caio Cesar
Paschetta, Carolina Andrea
de Azevedo, Soledad
Ramallo, Virginia
Acuña Alonzo, Victor
Adhikari, Kaustubh
Fuentes Guajardo, MacArena
Hünemeier, Tábita
Everardo, Paola
De Avila, Francisco
Jaramillo, Claudia
Arias, Williams
Gallo, Carla
Poletti, Giovani
Bedoya Berrío, Gabriel
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Rosique, Javier
Ruiz-Linares, Andres
González José, Rolando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HUMAN FACE
FLUCTUATING ASYMMETRY
GEOMETRIC MORPHOMETRIC
LATIN AMERICANS
topic HUMAN FACE
FLUCTUATING ASYMMETRY
GEOMETRIC MORPHOMETRIC
LATIN AMERICANS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Muñoz-Muñoz, Francesc. Universidad Nacional Autónoma de México; México
Fil: Gomez-Valdes, Jorge. Universitat Autònoma de Barcelona; España
Fil: Cintas, Celia. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Navarro, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Cerqueira, Caio Cesar Silva De. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paschetta, Carolina Andrea. Equipe de Perícias Criminalísticas de Ourinhos;
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Acuña-Alonzo, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido
Fil: Fuentes-Guajardo, MacArena. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Hünemeier, Tábita. Colegio Universitario de Londres; Reino Unido
Fil: Everardo, Paola. Universidad de Tarapaca de Arica; Chile
Fil: De Avila, Francisco. Colegio Universitario de Londres; Reino Unido
Fil: Jaramillo, Claudia. Universidade de Sao Paulo; Brasil
Fil: Arias, Williams. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Gallo, Carla. Universidad Nacional Autónoma de México; México
Fil: Poletti, Giovani. Instituto Nacional de Antropologia E Historia, Mexico; México
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria Catira. Universidad de Antioquia; Colombia
Fil: Canizales-Quinteros, Samuel. Universidad Peruana Cayetano Heredia; Perú
Fil: Rothhammer, Francisco. Universidad Peruana Cayetano Heredia; Perú
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Ruiz-Linares, Andres. Universidade Federal do Rio Grande do Sul; Brasil
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
description Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95265
Quinto Sanchez, Mirsha Emmanuel; Muñoz Muñoz, Francesc; Gomez Valdes, Jorge; Cintas, Celia; Navarro, Jose Pablo; et al.; Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-15
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95265
identifier_str_mv Quinto Sanchez, Mirsha Emmanuel; Muñoz Muñoz, Francesc; Gomez Valdes, Jorge; Cintas, Celia; Navarro, Jose Pablo; et al.; Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-15
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-19324-y
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-19324-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
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dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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