Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
- Autores
- Bouzat, Cecilia Beatriz
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise in the pharmaceutical industry search for new therapeutic compounds by high-throughput screening. Pentameric ligand gated ion channels, which include Cys-loop receptors, mediate rapid synaptic transmission by converting the chemical signal given by the neurotransmitter into an electrical one. These receptors play key roles in physiological processes, such as neuromuscular transmission, cognition, memory, and are targets of pharmacological compounds of clinical relevance. C. elegans has one of the most extended families of Cys-loop receptors, which have multiple functions including neuromuscular transmission. In particular, nicotinic (nAChR) and GABA receptors are essential for worm locomotion and are of clinical importance as targets of antiparasitic drugs. We combined paralysis assays, locomotion measurements and electrophysiological recordings from C. elegans cultured cells to identify the subunit composition, molecular function and antiparasitic drug modulation of muscle nAChR and GABA receptors. We also identified plant terpenoids and novel synthetic compounds that emerge as potential antiparasitic compounds by inducing rapid paralysis of C. elegans and deciphered the main drug targets and mechanisms underlying their anthelmintic actions. In order to use C. elegans as a model of human neuromuscular diseases, we generated transgenic strains containing mutant nAChRs that mimic those found in congenital myasthenic syndromes. We found that it is possible to recapitulate the molecular functional changes observed in patients, thus validating C. elegans as a model for these disorders.
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Reunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL)
Mar del Plata
Argentina
Sociedad Argentina de Investigación Clínica
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Biología
Sociedad Argentina de Protozoología
Asociación Argentina de Nanomedicinas
Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio
The Histochemical Society - Materia
-
CYS-LOOP RECEPTORS
CAENORHABDITIS ELEGANS
DRUG TARGET - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/161082
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Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)Bouzat, Cecilia BeatrizCYS-LOOP RECEPTORSCAENORHABDITIS ELEGANSDRUG TARGEThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise in the pharmaceutical industry search for new therapeutic compounds by high-throughput screening. Pentameric ligand gated ion channels, which include Cys-loop receptors, mediate rapid synaptic transmission by converting the chemical signal given by the neurotransmitter into an electrical one. These receptors play key roles in physiological processes, such as neuromuscular transmission, cognition, memory, and are targets of pharmacological compounds of clinical relevance. C. elegans has one of the most extended families of Cys-loop receptors, which have multiple functions including neuromuscular transmission. In particular, nicotinic (nAChR) and GABA receptors are essential for worm locomotion and are of clinical importance as targets of antiparasitic drugs. We combined paralysis assays, locomotion measurements and electrophysiological recordings from C. elegans cultured cells to identify the subunit composition, molecular function and antiparasitic drug modulation of muscle nAChR and GABA receptors. We also identified plant terpenoids and novel synthetic compounds that emerge as potential antiparasitic compounds by inducing rapid paralysis of C. elegans and deciphered the main drug targets and mechanisms underlying their anthelmintic actions. In order to use C. elegans as a model of human neuromuscular diseases, we generated transgenic strains containing mutant nAChRs that mimic those found in congenital myasthenic syndromes. We found that it is possible to recapitulate the molecular functional changes observed in patients, thus validating C. elegans as a model for these disorders.Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaReunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL)Mar del PlataArgentinaSociedad Argentina de Investigación ClínicaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de BiologíaSociedad Argentina de ProtozoologíaAsociación Argentina de NanomedicinasAsociación Argentina de Ciencia y Tecnología de Animales de LaboratorioThe Histochemical SocietyFundación Revista Medicina2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/161082Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio); Reunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL); Mar del Plata; Argentina; 2019; 36-360025-76801669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicinaNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:29Zoai:ri.conicet.gov.ar:11336/161082instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:29.931CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
title |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
spellingShingle |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) Bouzat, Cecilia Beatriz CYS-LOOP RECEPTORS CAENORHABDITIS ELEGANS DRUG TARGET |
title_short |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
title_full |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
title_fullStr |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
title_full_unstemmed |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
title_sort |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio) |
dc.creator.none.fl_str_mv |
Bouzat, Cecilia Beatriz |
author |
Bouzat, Cecilia Beatriz |
author_facet |
Bouzat, Cecilia Beatriz |
author_role |
author |
dc.subject.none.fl_str_mv |
CYS-LOOP RECEPTORS CAENORHABDITIS ELEGANS DRUG TARGET |
topic |
CYS-LOOP RECEPTORS CAENORHABDITIS ELEGANS DRUG TARGET |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise in the pharmaceutical industry search for new therapeutic compounds by high-throughput screening. Pentameric ligand gated ion channels, which include Cys-loop receptors, mediate rapid synaptic transmission by converting the chemical signal given by the neurotransmitter into an electrical one. These receptors play key roles in physiological processes, such as neuromuscular transmission, cognition, memory, and are targets of pharmacological compounds of clinical relevance. C. elegans has one of the most extended families of Cys-loop receptors, which have multiple functions including neuromuscular transmission. In particular, nicotinic (nAChR) and GABA receptors are essential for worm locomotion and are of clinical importance as targets of antiparasitic drugs. We combined paralysis assays, locomotion measurements and electrophysiological recordings from C. elegans cultured cells to identify the subunit composition, molecular function and antiparasitic drug modulation of muscle nAChR and GABA receptors. We also identified plant terpenoids and novel synthetic compounds that emerge as potential antiparasitic compounds by inducing rapid paralysis of C. elegans and deciphered the main drug targets and mechanisms underlying their anthelmintic actions. In order to use C. elegans as a model of human neuromuscular diseases, we generated transgenic strains containing mutant nAChRs that mimic those found in congenital myasthenic syndromes. We found that it is possible to recapitulate the molecular functional changes observed in patients, thus validating C. elegans as a model for these disorders. Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Reunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL) Mar del Plata Argentina Sociedad Argentina de Investigación Clínica Asociación Argentina de Farmacología Experimental Sociedad Argentina de Biología Sociedad Argentina de Protozoología Asociación Argentina de Nanomedicinas Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio The Histochemical Society |
description |
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise in the pharmaceutical industry search for new therapeutic compounds by high-throughput screening. Pentameric ligand gated ion channels, which include Cys-loop receptors, mediate rapid synaptic transmission by converting the chemical signal given by the neurotransmitter into an electrical one. These receptors play key roles in physiological processes, such as neuromuscular transmission, cognition, memory, and are targets of pharmacological compounds of clinical relevance. C. elegans has one of the most extended families of Cys-loop receptors, which have multiple functions including neuromuscular transmission. In particular, nicotinic (nAChR) and GABA receptors are essential for worm locomotion and are of clinical importance as targets of antiparasitic drugs. We combined paralysis assays, locomotion measurements and electrophysiological recordings from C. elegans cultured cells to identify the subunit composition, molecular function and antiparasitic drug modulation of muscle nAChR and GABA receptors. We also identified plant terpenoids and novel synthetic compounds that emerge as potential antiparasitic compounds by inducing rapid paralysis of C. elegans and deciphered the main drug targets and mechanisms underlying their anthelmintic actions. In order to use C. elegans as a model of human neuromuscular diseases, we generated transgenic strains containing mutant nAChRs that mimic those found in congenital myasthenic syndromes. We found that it is possible to recapitulate the molecular functional changes observed in patients, thus validating C. elegans as a model for these disorders. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/161082 Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio); Reunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL); Mar del Plata; Argentina; 2019; 36-36 0025-7680 1669-9106 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/161082 |
identifier_str_mv |
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio); Reunión Anual de Sociedades de Biociencia: LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); LI Reunión Anual de la Asociación Argentina de Farmacología Experimental (SAFE); XXI Reunión Anual de la Sociedad Argentina de Biología (SAB); XXXI Reunión Anual de la Sociedad Argentina de Protozoología (SAP); IX Reunión Anual de la Asociación Argentina de Nanomedicinas (NANOMED-ar) y VI Reunión Científica Regional de la Asociación Argentina de Ciencia y Tecnología de Animales de Laboratorio (AACyTAL); Mar del Plata; Argentina; 2019; 36-36 0025-7680 1669-9106 CONICET Digital CONICET |
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eng |
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eng |
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Nacional |
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Fundación Revista Medicina |
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Fundación Revista Medicina |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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