Is innervation an early target in autoimmune diabetes?
- Autores
- Saravia, Flavia Eugenia; Homo Delarche, Francoise
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; Francia - Materia
-
Nodmice
Innervation
Pancreas
Antigen - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/80432
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Is innervation an early target in autoimmune diabetes?Saravia, Flavia EugeniaHomo Delarche, FrancoiseNodmiceInnervationPancreasAntigenhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; FranciaElsevier2003-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80432Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-5791471-4906CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2003.09.010info:eu-repo/semantics/altIdentifier/pmid/14596878info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/immunology/fulltext/S1471-4906(03)00301-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:26Zoai:ri.conicet.gov.ar:11336/80432instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:26.354CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Is innervation an early target in autoimmune diabetes? |
title |
Is innervation an early target in autoimmune diabetes? |
spellingShingle |
Is innervation an early target in autoimmune diabetes? Saravia, Flavia Eugenia Nodmice Innervation Pancreas Antigen |
title_short |
Is innervation an early target in autoimmune diabetes? |
title_full |
Is innervation an early target in autoimmune diabetes? |
title_fullStr |
Is innervation an early target in autoimmune diabetes? |
title_full_unstemmed |
Is innervation an early target in autoimmune diabetes? |
title_sort |
Is innervation an early target in autoimmune diabetes? |
dc.creator.none.fl_str_mv |
Saravia, Flavia Eugenia Homo Delarche, Francoise |
author |
Saravia, Flavia Eugenia |
author_facet |
Saravia, Flavia Eugenia Homo Delarche, Francoise |
author_role |
author |
author2 |
Homo Delarche, Francoise |
author2_role |
author |
dc.subject.none.fl_str_mv |
Nodmice Innervation Pancreas Antigen |
topic |
Nodmice Innervation Pancreas Antigen |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis. Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; Francia |
description |
In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/80432 Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-579 1471-4906 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/80432 |
identifier_str_mv |
Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-579 1471-4906 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2003.09.010 info:eu-repo/semantics/altIdentifier/pmid/14596878 info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/immunology/fulltext/S1471-4906(03)00301-6 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844612989242572800 |
score |
13.070432 |