Is innervation an early target in autoimmune diabetes?

Autores
Saravia, Flavia Eugenia; Homo Delarche, Francoise
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; Francia
Materia
Nodmice
Innervation
Pancreas
Antigen
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80432
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/80432
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Is innervation an early target in autoimmune diabetes?Saravia, Flavia EugeniaHomo Delarche, FrancoiseNodmiceInnervationPancreasAntigenhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; FranciaElsevier2003-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80432Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-5791471-4906CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2003.09.010info:eu-repo/semantics/altIdentifier/pmid/14596878info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/immunology/fulltext/S1471-4906(03)00301-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:19Zoai:ri.conicet.gov.ar:11336/80432instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:19.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Is innervation an early target in autoimmune diabetes?
title Is innervation an early target in autoimmune diabetes?
spellingShingle Is innervation an early target in autoimmune diabetes?
Saravia, Flavia Eugenia
Nodmice
Innervation
Pancreas
Antigen
title_short Is innervation an early target in autoimmune diabetes?
title_full Is innervation an early target in autoimmune diabetes?
title_fullStr Is innervation an early target in autoimmune diabetes?
title_full_unstemmed Is innervation an early target in autoimmune diabetes?
title_sort Is innervation an early target in autoimmune diabetes?
dc.creator.none.fl_str_mv Saravia, Flavia Eugenia
Homo Delarche, Francoise
author Saravia, Flavia Eugenia
author_facet Saravia, Flavia Eugenia
Homo Delarche, Francoise
author_role author
author2 Homo Delarche, Francoise
author2_role author
dc.subject.none.fl_str_mv Nodmice
Innervation
Pancreas
Antigen
topic Nodmice
Innervation
Pancreas
Antigen
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.
Fil: Saravia, Flavia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Homo Delarche, Francoise. Centre National de la Recherche Scientifique; Francia. Université Paris Diderot - Paris 7; Francia
description In the non-obese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes (T1D), recent evidence suggests that Schwann cells (Scs) and neurons surrounding insulin-producing β cells of the islets of Langerhans are destroyed before β cells. During normal perinatal development, macrophages (MΦ) are involved in phagocytosis of apoptotic neurons. Pertinently, MΦ are already present at birth in NOD pancreata. Their possible abnormal control of nerve phagocytosis, together with transient β-cell hyperactivity and lymphocyte anomalies, might conjointly participate in T1D pathogenesis.
publishDate 2003
dc.date.none.fl_str_mv 2003-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80432
Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-579
1471-4906
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80432
identifier_str_mv Saravia, Flavia Eugenia; Homo Delarche, Francoise; Is innervation an early target in autoimmune diabetes?; Elsevier; Trends In Immunology; 24; 11; 5-2003; 574-579
1471-4906
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.it.2003.09.010
info:eu-repo/semantics/altIdentifier/pmid/14596878
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/immunology/fulltext/S1471-4906(03)00301-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082577232822272
score 13.22299

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