Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus

Autores
Sanchez, Sara Serafina del V.; Aybar, Manuel Javier; Velarde, M.S.; Prado, M.M.; Carrizo T.R.
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pathogenesis of the vascular complications of diabetes is controversial, micro- and macroangiopathy being the most common cause of morbidity and mortality in diabetic patients. Endothelial cell damage, thought to occur in diabetic patients, may be an important factor in development of angiopathy . For the last few years, considerable evidence has connected endothelin-1 (ET-1), a strong endothelial-derived vasoconstrictor mitogenic peptide, with various cardiovascular disease states . Plasma ET-1 concentrations were found to be abnormally high in patients with conditions associated with endothelial cell injury, as well as in those with hypertension , congestive heart failure , coronary artery disease, and uremia . Contradictory findings regarding ET-1 levels have been reported in patients suffering from diabetes mellitus . Bertello et al. and Kanno et al. described similar plasma ET-1 levels in both healthy controls and patients with non-insulin-dependent diabetes mellitus (Type 2 diabetes) with and without complications. However, the influence of Type 2 diabetes on plasma endothelin levels was definitely established in patients with advanced atherosclerosis . Recent clinical studies have indicated that the normalization of glycemic control cannot only prevent diabetic microangiopathies, but might possibly avert cardiovascular complications , thus pointing to hyperglycemia as the major causal factor in the development of diabetic vascular complications. Moreover, there are indications that high blood glucose is involved in the pathogenesis of coronary heart disease, being a significant factor in cardiovascular mortality . However, in spite of the significant effects of hyperglycemia, very few studies have dealt with the possible influence of glucose metabolic control on endothelial reactivity in Type 2 diabetic patients. The aims of the present paper were a) to establish the possible relationship between plasma ET-1 levels and Type 2 diabetes by comparing plasma ET-1 concentrations in healthy subjects with those in patients with uncomplicated Type 2 diabetes and b) to determine whether ET-1 levels were related to glucose metabolic control in diabetic patients.
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Velarde, M.S.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Prado, M.M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Carrizo T.R.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
endothelin-1
diabetes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97944
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/97944
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes MellitusSanchez, Sara Serafina del V.Aybar, Manuel JavierVelarde, M.S.Prado, M.M.Carrizo T.R.endothelin-1diabeteshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The pathogenesis of the vascular complications of diabetes is controversial, micro- and macroangiopathy being the most common cause of morbidity and mortality in diabetic patients. Endothelial cell damage, thought to occur in diabetic patients, may be an important factor in development of angiopathy . For the last few years, considerable evidence has connected endothelin-1 (ET-1), a strong endothelial-derived vasoconstrictor mitogenic peptide, with various cardiovascular disease states . Plasma ET-1 concentrations were found to be abnormally high in patients with conditions associated with endothelial cell injury, as well as in those with hypertension , congestive heart failure , coronary artery disease, and uremia . Contradictory findings regarding ET-1 levels have been reported in patients suffering from diabetes mellitus . Bertello et al. and Kanno et al. described similar plasma ET-1 levels in both healthy controls and patients with non-insulin-dependent diabetes mellitus (Type 2 diabetes) with and without complications. However, the influence of Type 2 diabetes on plasma endothelin levels was definitely established in patients with advanced atherosclerosis . Recent clinical studies have indicated that the normalization of glycemic control cannot only prevent diabetic microangiopathies, but might possibly avert cardiovascular complications , thus pointing to hyperglycemia as the major causal factor in the development of diabetic vascular complications. Moreover, there are indications that high blood glucose is involved in the pathogenesis of coronary heart disease, being a significant factor in cardiovascular mortality . However, in spite of the significant effects of hyperglycemia, very few studies have dealt with the possible influence of glucose metabolic control on endothelial reactivity in Type 2 diabetic patients. The aims of the present paper were a) to establish the possible relationship between plasma ET-1 levels and Type 2 diabetes by comparing plasma ET-1 concentrations in healthy subjects with those in patients with uncomplicated Type 2 diabetes and b) to determine whether ET-1 levels were related to glucose metabolic control in diabetic patients.Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Velarde, M.S.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Prado, M.M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Carrizo T.R.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaGeorg Thieme Verlag Kg2001-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97944Sanchez, Sara Serafina del V.; Aybar, Manuel Javier; Velarde, M.S.; Prado, M.M.; Carrizo T.R.; Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 33; 12; 12-2001; 748-7510018-5043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/s-2001-19137info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2001-19137info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:57Zoai:ri.conicet.gov.ar:11336/97944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:57.382CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
title Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
spellingShingle Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
Sanchez, Sara Serafina del V.
endothelin-1
diabetes
title_short Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
title_full Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
title_fullStr Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
title_full_unstemmed Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
title_sort Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus
dc.creator.none.fl_str_mv Sanchez, Sara Serafina del V.
Aybar, Manuel Javier
Velarde, M.S.
Prado, M.M.
Carrizo T.R.
author Sanchez, Sara Serafina del V.
author_facet Sanchez, Sara Serafina del V.
Aybar, Manuel Javier
Velarde, M.S.
Prado, M.M.
Carrizo T.R.
author_role author
author2 Aybar, Manuel Javier
Velarde, M.S.
Prado, M.M.
Carrizo T.R.
author2_role author
author
author
author
dc.subject.none.fl_str_mv endothelin-1
diabetes
topic endothelin-1
diabetes
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The pathogenesis of the vascular complications of diabetes is controversial, micro- and macroangiopathy being the most common cause of morbidity and mortality in diabetic patients. Endothelial cell damage, thought to occur in diabetic patients, may be an important factor in development of angiopathy . For the last few years, considerable evidence has connected endothelin-1 (ET-1), a strong endothelial-derived vasoconstrictor mitogenic peptide, with various cardiovascular disease states . Plasma ET-1 concentrations were found to be abnormally high in patients with conditions associated with endothelial cell injury, as well as in those with hypertension , congestive heart failure , coronary artery disease, and uremia . Contradictory findings regarding ET-1 levels have been reported in patients suffering from diabetes mellitus . Bertello et al. and Kanno et al. described similar plasma ET-1 levels in both healthy controls and patients with non-insulin-dependent diabetes mellitus (Type 2 diabetes) with and without complications. However, the influence of Type 2 diabetes on plasma endothelin levels was definitely established in patients with advanced atherosclerosis . Recent clinical studies have indicated that the normalization of glycemic control cannot only prevent diabetic microangiopathies, but might possibly avert cardiovascular complications , thus pointing to hyperglycemia as the major causal factor in the development of diabetic vascular complications. Moreover, there are indications that high blood glucose is involved in the pathogenesis of coronary heart disease, being a significant factor in cardiovascular mortality . However, in spite of the significant effects of hyperglycemia, very few studies have dealt with the possible influence of glucose metabolic control on endothelial reactivity in Type 2 diabetic patients. The aims of the present paper were a) to establish the possible relationship between plasma ET-1 levels and Type 2 diabetes by comparing plasma ET-1 concentrations in healthy subjects with those in patients with uncomplicated Type 2 diabetes and b) to determine whether ET-1 levels were related to glucose metabolic control in diabetic patients.
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Aybar, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Velarde, M.S.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Prado, M.M.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Carrizo T.R.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description The pathogenesis of the vascular complications of diabetes is controversial, micro- and macroangiopathy being the most common cause of morbidity and mortality in diabetic patients. Endothelial cell damage, thought to occur in diabetic patients, may be an important factor in development of angiopathy . For the last few years, considerable evidence has connected endothelin-1 (ET-1), a strong endothelial-derived vasoconstrictor mitogenic peptide, with various cardiovascular disease states . Plasma ET-1 concentrations were found to be abnormally high in patients with conditions associated with endothelial cell injury, as well as in those with hypertension , congestive heart failure , coronary artery disease, and uremia . Contradictory findings regarding ET-1 levels have been reported in patients suffering from diabetes mellitus . Bertello et al. and Kanno et al. described similar plasma ET-1 levels in both healthy controls and patients with non-insulin-dependent diabetes mellitus (Type 2 diabetes) with and without complications. However, the influence of Type 2 diabetes on plasma endothelin levels was definitely established in patients with advanced atherosclerosis . Recent clinical studies have indicated that the normalization of glycemic control cannot only prevent diabetic microangiopathies, but might possibly avert cardiovascular complications , thus pointing to hyperglycemia as the major causal factor in the development of diabetic vascular complications. Moreover, there are indications that high blood glucose is involved in the pathogenesis of coronary heart disease, being a significant factor in cardiovascular mortality . However, in spite of the significant effects of hyperglycemia, very few studies have dealt with the possible influence of glucose metabolic control on endothelial reactivity in Type 2 diabetic patients. The aims of the present paper were a) to establish the possible relationship between plasma ET-1 levels and Type 2 diabetes by comparing plasma ET-1 concentrations in healthy subjects with those in patients with uncomplicated Type 2 diabetes and b) to determine whether ET-1 levels were related to glucose metabolic control in diabetic patients.
publishDate 2001
dc.date.none.fl_str_mv 2001-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97944
Sanchez, Sara Serafina del V.; Aybar, Manuel Javier; Velarde, M.S.; Prado, M.M.; Carrizo T.R.; Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 33; 12; 12-2001; 748-751
0018-5043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97944
identifier_str_mv Sanchez, Sara Serafina del V.; Aybar, Manuel Javier; Velarde, M.S.; Prado, M.M.; Carrizo T.R.; Relationship between Plasma Endothelin-1 and Glycemic Control in Type 2 Diabetes Mellitus; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 33; 12; 12-2001; 748-751
0018-5043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1055/s-2001-19137
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2001-19137
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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