N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds

Autores
Nóbile, Matías Leonardo; Stricker, Abigail M.; Marchesano, Lucas; Iribarren, Adolfo Marcelo; Lewkowicz, Elizabeth Sandra
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Among the compounds that contain unusual functional groups, nitro is perhaps one of the most interesting due to the valuable properties it confers on pharmaceuticals and explosives. Traditional chemistry has for many years used environmentally unfriendly strategies; in contrast, the biocatalyzed production of this type of products offers a promising alternative. The small family of enzymes formed by N-oxygenases allows the conversion of an amino group to a nitro through the sequential addition of oxygen. These enzymes also make it possible to obtain other less oxidized N-O functions, such as hydroxylamine or nitroso, present in intermediate or final products. The current substrates on which these enzymes are reported to work encompass a few aromatic molecules and sugars. The unique characteristics of N-oxygenases and the great economic value of the products that they could generate, place them in a position of very high scientific and industrial interest. The most important and best studied N-oxygenases will be presented here.
Fil: Nóbile, Matías Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
Fil: Stricker, Abigail M.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Marchesano, Lucas. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
Materia
MONOOXYGENASES
N-OXYGENASES
N-OXYGENATION
NITRO COMPOUNDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165990
Acceder
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network_name_str CONICET Digital (CONICET)
spelling N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compoundsNóbile, Matías LeonardoStricker, Abigail M.Marchesano, LucasIribarren, Adolfo MarceloLewkowicz, Elizabeth SandraMONOOXYGENASESN-OXYGENASESN-OXYGENATIONNITRO COMPOUNDShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Among the compounds that contain unusual functional groups, nitro is perhaps one of the most interesting due to the valuable properties it confers on pharmaceuticals and explosives. Traditional chemistry has for many years used environmentally unfriendly strategies; in contrast, the biocatalyzed production of this type of products offers a promising alternative. The small family of enzymes formed by N-oxygenases allows the conversion of an amino group to a nitro through the sequential addition of oxygen. These enzymes also make it possible to obtain other less oxidized N-O functions, such as hydroxylamine or nitroso, present in intermediate or final products. The current substrates on which these enzymes are reported to work encompass a few aromatic molecules and sugars. The unique characteristics of N-oxygenases and the great economic value of the products that they could generate, place them in a position of very high scientific and industrial interest. The most important and best studied N-oxygenases will be presented here.Fil: Nóbile, Matías Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; ArgentinaFil: Stricker, Abigail M.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Marchesano, Lucas. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; ArgentinaFil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; ArgentinaElsevier2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165990Nóbile, Matías Leonardo; Stricker, Abigail M.; Marchesano, Lucas; Iribarren, Adolfo Marcelo; Lewkowicz, Elizabeth Sandra; N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds; Elsevier; Biotechnology Advances; 51; 11-2021; 1-120734-9750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S073497502100032Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2021.107726info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:25:33Zoai:ri.conicet.gov.ar:11336/165990instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:25:33.55CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
title N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
spellingShingle N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
Nóbile, Matías Leonardo
MONOOXYGENASES
N-OXYGENASES
N-OXYGENATION
NITRO COMPOUNDS
title_short N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
title_full N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
title_fullStr N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
title_full_unstemmed N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
title_sort N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds
dc.creator.none.fl_str_mv Nóbile, Matías Leonardo
Stricker, Abigail M.
Marchesano, Lucas
Iribarren, Adolfo Marcelo
Lewkowicz, Elizabeth Sandra
author Nóbile, Matías Leonardo
author_facet Nóbile, Matías Leonardo
Stricker, Abigail M.
Marchesano, Lucas
Iribarren, Adolfo Marcelo
Lewkowicz, Elizabeth Sandra
author_role author
author2 Stricker, Abigail M.
Marchesano, Lucas
Iribarren, Adolfo Marcelo
Lewkowicz, Elizabeth Sandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv MONOOXYGENASES
N-OXYGENASES
N-OXYGENATION
NITRO COMPOUNDS
topic MONOOXYGENASES
N-OXYGENASES
N-OXYGENATION
NITRO COMPOUNDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Among the compounds that contain unusual functional groups, nitro is perhaps one of the most interesting due to the valuable properties it confers on pharmaceuticals and explosives. Traditional chemistry has for many years used environmentally unfriendly strategies; in contrast, the biocatalyzed production of this type of products offers a promising alternative. The small family of enzymes formed by N-oxygenases allows the conversion of an amino group to a nitro through the sequential addition of oxygen. These enzymes also make it possible to obtain other less oxidized N-O functions, such as hydroxylamine or nitroso, present in intermediate or final products. The current substrates on which these enzymes are reported to work encompass a few aromatic molecules and sugars. The unique characteristics of N-oxygenases and the great economic value of the products that they could generate, place them in a position of very high scientific and industrial interest. The most important and best studied N-oxygenases will be presented here.
Fil: Nóbile, Matías Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
Fil: Stricker, Abigail M.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Marchesano, Lucas. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres". Grupo Vinculado al INGEBI- Laboratorio de Biocatálisis y Biotransformaciones - LBB - UNQUI; Argentina
description Among the compounds that contain unusual functional groups, nitro is perhaps one of the most interesting due to the valuable properties it confers on pharmaceuticals and explosives. Traditional chemistry has for many years used environmentally unfriendly strategies; in contrast, the biocatalyzed production of this type of products offers a promising alternative. The small family of enzymes formed by N-oxygenases allows the conversion of an amino group to a nitro through the sequential addition of oxygen. These enzymes also make it possible to obtain other less oxidized N-O functions, such as hydroxylamine or nitroso, present in intermediate or final products. The current substrates on which these enzymes are reported to work encompass a few aromatic molecules and sugars. The unique characteristics of N-oxygenases and the great economic value of the products that they could generate, place them in a position of very high scientific and industrial interest. The most important and best studied N-oxygenases will be presented here.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165990
Nóbile, Matías Leonardo; Stricker, Abigail M.; Marchesano, Lucas; Iribarren, Adolfo Marcelo; Lewkowicz, Elizabeth Sandra; N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds; Elsevier; Biotechnology Advances; 51; 11-2021; 1-12
0734-9750
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165990
identifier_str_mv Nóbile, Matías Leonardo; Stricker, Abigail M.; Marchesano, Lucas; Iribarren, Adolfo Marcelo; Lewkowicz, Elizabeth Sandra; N-oxygenation of amino compounds: early stages in its application to the biocatalyzed preparation of bioactive compounds; Elsevier; Biotechnology Advances; 51; 11-2021; 1-12
0734-9750
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S073497502100032X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biotechadv.2021.107726
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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