Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina

Autores
Urrets Zavalía, Julio Alberto; Crim, Nicolás; Knoll, Erna G.; Espósito, Fernando Augusto; Collino, Elizabeth; Urrets Zavalía, Maria E.; Saenz de Tejada, Graciela; Torrealday, Juan Ignacio; Serra, Horacio Marcelo; Gilbert, Clare
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). Methods: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors for ROP were examined through three different time periods: period 1: high target oxygen saturation levels (88–96%) and treatment at threshold ROP; period 2: low target oxygen saturation levels (83–93%) and treatment at threshold ROP; period 3: low target oxygen saturation and treatment at type 1 ROP. Results: Type 1 ROP was detected more frequently in babies of 32 weeks GA or less (50/365, 13.7%) than in more mature babies (15/1167, 1.3%; p<0.001). The rate of type 1 ROP in period 1 was 6.9%; period 2, 3.6% and period 3, 1.8%. Rates of stage 3 ROP declined over time in both BW/GA groups (from 9.0% to 4.1% to 2.0%) as did rates of plus disease (from 7.5% to 3.6% to 1.8%). Mean BW and GA declined from period 1 to period 3, and death rates remained unchanged. 74.4% of babies received all the examinations required; 48.1% of treatments were undertaken after discharge from the neonatal unit. Conclusions: Lower target oxygen saturation was associated with a lower rate of severe ROP without increasing mortality, and changed the characteristics of affected babies. Screening criteria need to remain wide enough to identify all babies at risk of ROP needing treatment.
Fil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Espósito, Fernando Augusto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Collino, Elizabeth. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Urrets Zavalía, Maria E.. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Saenz de Tejada, Graciela. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Torrealday, Juan Ignacio. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gilbert, Clare. London School of Hygiene and Tropical Medicine; Reino Unido
Materia
Retinopathy
Oxygenation
Blindness
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27157
Acceder
id CONICETDig_30504bd8f50aefa9872d9e28cb306e2d
oai_identifier_str oai:ri.conicet.gov.ar:11336/27157
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in ArgentinaUrrets Zavalía, Julio AlbertoCrim, NicolásKnoll, Erna G.Espósito, Fernando AugustoCollino, ElizabethUrrets Zavalía, Maria E.Saenz de Tejada, GracielaTorrealday, Juan IgnacioSerra, Horacio MarceloGilbert, ClareRetinopathyOxygenationBlindnesshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aims: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). Methods: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors for ROP were examined through three different time periods: period 1: high target oxygen saturation levels (88–96%) and treatment at threshold ROP; period 2: low target oxygen saturation levels (83–93%) and treatment at threshold ROP; period 3: low target oxygen saturation and treatment at type 1 ROP. Results: Type 1 ROP was detected more frequently in babies of 32 weeks GA or less (50/365, 13.7%) than in more mature babies (15/1167, 1.3%; p<0.001). The rate of type 1 ROP in period 1 was 6.9%; period 2, 3.6% and period 3, 1.8%. Rates of stage 3 ROP declined over time in both BW/GA groups (from 9.0% to 4.1% to 2.0%) as did rates of plus disease (from 7.5% to 3.6% to 1.8%). Mean BW and GA declined from period 1 to period 3, and death rates remained unchanged. 74.4% of babies received all the examinations required; 48.1% of treatments were undertaken after discharge from the neonatal unit. Conclusions: Lower target oxygen saturation was associated with a lower rate of severe ROP without increasing mortality, and changed the characteristics of affected babies. Screening criteria need to remain wide enough to identify all babies at risk of ROP needing treatment.Fil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; ArgentinaFil: Espósito, Fernando Augusto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Collino, Elizabeth. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; ArgentinaFil: Urrets Zavalía, Maria E.. Universidad Catolica de Córdoba. Facultad de Medicina; ArgentinaFil: Saenz de Tejada, Graciela. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; ArgentinaFil: Torrealday, Juan Ignacio. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gilbert, Clare. London School of Hygiene and Tropical Medicine; Reino UnidoB M J Publishing Group2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27157Urrets Zavalía, Julio Alberto; Crim, Nicolás; Knoll, Erna G.; Espósito, Fernando Augusto; Collino, Elizabeth; et al.; Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina; B M J Publishing Group; British Journal Of Ophthalmology; 96; 12; 10-2013; 1456-14610007-1161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1136/bjophthalmol-2011-301394info:eu-repo/semantics/altIdentifier/url/http://bjo.bmj.com/content/96/12/1456info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:31Zoai:ri.conicet.gov.ar:11336/27157instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:31.724CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
title Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
spellingShingle Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
Urrets Zavalía, Julio Alberto
Retinopathy
Oxygenation
Blindness
title_short Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
title_full Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
title_fullStr Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
title_full_unstemmed Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
title_sort Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina
dc.creator.none.fl_str_mv Urrets Zavalía, Julio Alberto
Crim, Nicolás
Knoll, Erna G.
Espósito, Fernando Augusto
Collino, Elizabeth
Urrets Zavalía, Maria E.
Saenz de Tejada, Graciela
Torrealday, Juan Ignacio
Serra, Horacio Marcelo
Gilbert, Clare
author Urrets Zavalía, Julio Alberto
author_facet Urrets Zavalía, Julio Alberto
Crim, Nicolás
Knoll, Erna G.
Espósito, Fernando Augusto
Collino, Elizabeth
Urrets Zavalía, Maria E.
Saenz de Tejada, Graciela
Torrealday, Juan Ignacio
Serra, Horacio Marcelo
Gilbert, Clare
author_role author
author2 Crim, Nicolás
Knoll, Erna G.
Espósito, Fernando Augusto
Collino, Elizabeth
Urrets Zavalía, Maria E.
Saenz de Tejada, Graciela
Torrealday, Juan Ignacio
Serra, Horacio Marcelo
Gilbert, Clare
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Retinopathy
Oxygenation
Blindness
topic Retinopathy
Oxygenation
Blindness
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). Methods: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors for ROP were examined through three different time periods: period 1: high target oxygen saturation levels (88–96%) and treatment at threshold ROP; period 2: low target oxygen saturation levels (83–93%) and treatment at threshold ROP; period 3: low target oxygen saturation and treatment at type 1 ROP. Results: Type 1 ROP was detected more frequently in babies of 32 weeks GA or less (50/365, 13.7%) than in more mature babies (15/1167, 1.3%; p<0.001). The rate of type 1 ROP in period 1 was 6.9%; period 2, 3.6% and period 3, 1.8%. Rates of stage 3 ROP declined over time in both BW/GA groups (from 9.0% to 4.1% to 2.0%) as did rates of plus disease (from 7.5% to 3.6% to 1.8%). Mean BW and GA declined from period 1 to period 3, and death rates remained unchanged. 74.4% of babies received all the examinations required; 48.1% of treatments were undertaken after discharge from the neonatal unit. Conclusions: Lower target oxygen saturation was associated with a lower rate of severe ROP without increasing mortality, and changed the characteristics of affected babies. Screening criteria need to remain wide enough to identify all babies at risk of ROP needing treatment.
Fil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Knoll, Erna G.. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Espósito, Fernando Augusto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Collino, Elizabeth. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Urrets Zavalía, Maria E.. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Saenz de Tejada, Graciela. Provincia de Córdoba. Hospital Materno Neonatal "Ramon Carrillo"; Argentina
Fil: Torrealday, Juan Ignacio. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gilbert, Clare. London School of Hygiene and Tropical Medicine; Reino Unido
description Aims: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). Methods: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors for ROP were examined through three different time periods: period 1: high target oxygen saturation levels (88–96%) and treatment at threshold ROP; period 2: low target oxygen saturation levels (83–93%) and treatment at threshold ROP; period 3: low target oxygen saturation and treatment at type 1 ROP. Results: Type 1 ROP was detected more frequently in babies of 32 weeks GA or less (50/365, 13.7%) than in more mature babies (15/1167, 1.3%; p<0.001). The rate of type 1 ROP in period 1 was 6.9%; period 2, 3.6% and period 3, 1.8%. Rates of stage 3 ROP declined over time in both BW/GA groups (from 9.0% to 4.1% to 2.0%) as did rates of plus disease (from 7.5% to 3.6% to 1.8%). Mean BW and GA declined from period 1 to period 3, and death rates remained unchanged. 74.4% of babies received all the examinations required; 48.1% of treatments were undertaken after discharge from the neonatal unit. Conclusions: Lower target oxygen saturation was associated with a lower rate of severe ROP without increasing mortality, and changed the characteristics of affected babies. Screening criteria need to remain wide enough to identify all babies at risk of ROP needing treatment.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27157
Urrets Zavalía, Julio Alberto; Crim, Nicolás; Knoll, Erna G.; Espósito, Fernando Augusto; Collino, Elizabeth; et al.; Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina; B M J Publishing Group; British Journal Of Ophthalmology; 96; 12; 10-2013; 1456-1461
0007-1161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27157
identifier_str_mv Urrets Zavalía, Julio Alberto; Crim, Nicolás; Knoll, Erna G.; Espósito, Fernando Augusto; Collino, Elizabeth; et al.; Impact of changing oxygenation policies on retinopathy of prematurity in a neonatal unit in Argentina; B M J Publishing Group; British Journal Of Ophthalmology; 96; 12; 10-2013; 1456-1461
0007-1161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1136/bjophthalmol-2011-301394
info:eu-repo/semantics/altIdentifier/url/http://bjo.bmj.com/content/96/12/1456
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv B M J Publishing Group
publisher.none.fl_str_mv B M J Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980837787697152
score 12.993085

Publicaciones similares