Modified silica matrices for controlled release of cephalexin

Autores
Legnoverde, María Soledad; Jiménez Morales, Ignacio; Jiménez-Morales, Alberto; Rodríguez Castellón, Enrique; Basaldella, Elena Isabel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV–visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.
Fil: Legnoverde, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigación y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
Fil: Jiménez Morales, Ignacio . Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
Fil: Jiménez-Morales, Alberto. Hospital Virgen de las Nieves. Servicio de Farmacia; España
Fil: Rodríguez Castellón, Enrique. Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
Fil: Basaldella, Elena Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigacion y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
Materia
Sba-15
Mesoporous Silicas
Surface Functionalization
Drug Adsorption
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4930
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/4930
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modified silica matrices for controlled release of cephalexinLegnoverde, María SoledadJiménez Morales, Ignacio Jiménez-Morales, AlbertoRodríguez Castellón, EnriqueBasaldella, Elena IsabelSba-15Mesoporous SilicasSurface FunctionalizationDrug Adsorptionhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV–visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.Fil: Legnoverde, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigación y Desarrollo en Ciencia y Tecnologia de Materiales; ArgentinaFil: Jiménez Morales, Ignacio . Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; EspañaFil: Jiménez-Morales, Alberto. Hospital Virgen de las Nieves. Servicio de Farmacia; EspañaFil: Rodríguez Castellón, Enrique. Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; EspañaFil: Basaldella, Elena Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigacion y Desarrollo en Ciencia y Tecnologia de Materiales; ArgentinaBentham Science Publishers2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4930Legnoverde, María Soledad; Jiménez Morales, Ignacio ; Jiménez-Morales, Alberto; Rodríguez Castellón, Enrique; Basaldella, Elena Isabel; Modified silica matrices for controlled release of cephalexin; Bentham Science Publishers; Medicinal Chemistry; 9; 5; 8-2013; 672-6801573-40641875-6638enginfo:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/ben/mc/2013/00000009/00000005/art00006info:eu-repo/semantics/altIdentifier/doi/10.2174/1573406411309050006info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/111602/articleinfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/pmid/23061564info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:23Zoai:ri.conicet.gov.ar:11336/4930instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:23.907CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modified silica matrices for controlled release of cephalexin
title Modified silica matrices for controlled release of cephalexin
spellingShingle Modified silica matrices for controlled release of cephalexin
Legnoverde, María Soledad
Sba-15
Mesoporous Silicas
Surface Functionalization
Drug Adsorption
title_short Modified silica matrices for controlled release of cephalexin
title_full Modified silica matrices for controlled release of cephalexin
title_fullStr Modified silica matrices for controlled release of cephalexin
title_full_unstemmed Modified silica matrices for controlled release of cephalexin
title_sort Modified silica matrices for controlled release of cephalexin
dc.creator.none.fl_str_mv Legnoverde, María Soledad
Jiménez Morales, Ignacio
Jiménez-Morales, Alberto
Rodríguez Castellón, Enrique
Basaldella, Elena Isabel
author Legnoverde, María Soledad
author_facet Legnoverde, María Soledad
Jiménez Morales, Ignacio
Jiménez-Morales, Alberto
Rodríguez Castellón, Enrique
Basaldella, Elena Isabel
author_role author
author2 Jiménez Morales, Ignacio
Jiménez-Morales, Alberto
Rodríguez Castellón, Enrique
Basaldella, Elena Isabel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Sba-15
Mesoporous Silicas
Surface Functionalization
Drug Adsorption
topic Sba-15
Mesoporous Silicas
Surface Functionalization
Drug Adsorption
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV–visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.
Fil: Legnoverde, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigación y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
Fil: Jiménez Morales, Ignacio . Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
Fil: Jiménez-Morales, Alberto. Hospital Virgen de las Nieves. Servicio de Farmacia; España
Fil: Rodríguez Castellón, Enrique. Universidad de Málaga. Facultad de Ciencias. Unidad asociada al Instituto de Catálisis. Departamento de Química Inorganica; España
Fil: Basaldella, Elena Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigación y Desarrollo En Ciencias Aplicadas; Argentina. Universidad Tecnologica Nacional. Facultad Reional La Plata. Centro de Investigacion y Desarrollo en Ciencia y Tecnologia de Materiales; Argentina
description SBA-15 type ordered silicas possessing amino groups attached onto their surfaces were prepared by using two different functionalization methodologies. These matrices were used for the cephalexin adsorption from aqueous solution and further kinetic study of its release into physiological solution. The materials were characterized by nitrogen adsorption/ desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV–visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded amino groups and their location, which in turn is determined by the functionalization procedure used. It was concluded that amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4930
Legnoverde, María Soledad; Jiménez Morales, Ignacio ; Jiménez-Morales, Alberto; Rodríguez Castellón, Enrique; Basaldella, Elena Isabel; Modified silica matrices for controlled release of cephalexin; Bentham Science Publishers; Medicinal Chemistry; 9; 5; 8-2013; 672-680
1573-4064
1875-6638
url http://hdl.handle.net/11336/4930
identifier_str_mv Legnoverde, María Soledad; Jiménez Morales, Ignacio ; Jiménez-Morales, Alberto; Rodríguez Castellón, Enrique; Basaldella, Elena Isabel; Modified silica matrices for controlled release of cephalexin; Bentham Science Publishers; Medicinal Chemistry; 9; 5; 8-2013; 672-680
1573-4064
1875-6638
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/ben/mc/2013/00000009/00000005/art00006
info:eu-repo/semantics/altIdentifier/doi/10.2174/1573406411309050006
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/111602/article
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/pmid/23061564
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268921195921408
score 13.13397

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