Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups

Autores
Montiel Centeno, Kiara Yanibeth; Barrera Diaz, Deicy Amparo; García Villén, Fátima; Sánchez Espejo, Rita; Borrego Sánchez, Ana; Castellon, Enrique Rodriguez; Sandri, Giuseppina; Viseras, César; Sapag, Manuel Karim
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
KIT-6 mesoporous silica has been synthesized using the sol-gel method and functionalized with 3-aminopropyl triethoxysilane by grafting route to obtain KIT-6/NH2. These samples were used as carriers in the loading and controlled release of cephalexin (CFX). The effect of temperature and gastric and intestinal pH on the stability of pure CFX and loaded in KIT-6 and KIT-6/NH2 were investigated. The properties of the synthesized materials and their CFX loading capacity were studied through FTIR, ads-des N2 at 77 K, TEM, SEM, XPS, and TGA. The controlled release tests were carried out in a simulated physiological medium at gastric (1.2) and intestinal pH (6.8). Furthermore, the biocompatibility of both materials was studied through cell viability tests in Caco-2 intestinal cells. The results revealed that KIT-6 and KIT-6/NH2 had similar CFX loading capacities. It was found that CFX degrades at pH 6.8, however, KIT-6 and KIT-6/NH2 were able to protect it from the aforementioned degradation. Moreover, KIT-6 materials presented a good performance as CFX carriers since both materials provided diffusion-controlled release profiles during 24 h, satisfying the Korsmeyer-Peppas kinetic model. Mesoporous silicas presented in this work are promising candidates to be used in CFX controlled release systems due to their chemical interactions, textural properties, and high cell viability.
Fil: Montiel Centeno, Kiara Yanibeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Barrera Diaz, Deicy Amparo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: García Villén, Fátima. Universidad de Granada. Facultad de Farmacia.; España
Fil: Sánchez Espejo, Rita. Universidad de Granada. Facultad de Farmacia.; España
Fil: Borrego Sánchez, Ana. Universidad de Granada. Facultad de Farmacia.; España
Fil: Castellon, Enrique Rodriguez. Universidad de Málaga; España
Fil: Sandri, Giuseppina. Universita Degli Studi Di Pavia; Italia
Fil: Viseras, César. Universidad de Granada. Facultad de Farmacia.; España
Fil: Sapag, Manuel Karim. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Materia
CEPHALEXIN
DRUG DELIVERY SYSTEM
FUNCTIONALIZATION
KIT-6
LOADING
RELEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211952
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/211952
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groupsMontiel Centeno, Kiara YanibethBarrera Diaz, Deicy AmparoGarcía Villén, FátimaSánchez Espejo, RitaBorrego Sánchez, AnaCastellon, Enrique RodriguezSandri, GiuseppinaViseras, CésarSapag, Manuel KarimCEPHALEXINDRUG DELIVERY SYSTEMFUNCTIONALIZATIONKIT-6LOADINGRELEASEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2KIT-6 mesoporous silica has been synthesized using the sol-gel method and functionalized with 3-aminopropyl triethoxysilane by grafting route to obtain KIT-6/NH2. These samples were used as carriers in the loading and controlled release of cephalexin (CFX). The effect of temperature and gastric and intestinal pH on the stability of pure CFX and loaded in KIT-6 and KIT-6/NH2 were investigated. The properties of the synthesized materials and their CFX loading capacity were studied through FTIR, ads-des N2 at 77 K, TEM, SEM, XPS, and TGA. The controlled release tests were carried out in a simulated physiological medium at gastric (1.2) and intestinal pH (6.8). Furthermore, the biocompatibility of both materials was studied through cell viability tests in Caco-2 intestinal cells. The results revealed that KIT-6 and KIT-6/NH2 had similar CFX loading capacities. It was found that CFX degrades at pH 6.8, however, KIT-6 and KIT-6/NH2 were able to protect it from the aforementioned degradation. Moreover, KIT-6 materials presented a good performance as CFX carriers since both materials provided diffusion-controlled release profiles during 24 h, satisfying the Korsmeyer-Peppas kinetic model. Mesoporous silicas presented in this work are promising candidates to be used in CFX controlled release systems due to their chemical interactions, textural properties, and high cell viability.Fil: Montiel Centeno, Kiara Yanibeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: Barrera Diaz, Deicy Amparo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaFil: García Villén, Fátima. Universidad de Granada. Facultad de Farmacia.; EspañaFil: Sánchez Espejo, Rita. Universidad de Granada. Facultad de Farmacia.; EspañaFil: Borrego Sánchez, Ana. Universidad de Granada. Facultad de Farmacia.; EspañaFil: Castellon, Enrique Rodriguez. Universidad de Málaga; EspañaFil: Sandri, Giuseppina. Universita Degli Studi Di Pavia; ItaliaFil: Viseras, César. Universidad de Granada. Facultad de Farmacia.; EspañaFil: Sapag, Manuel Karim. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; ArgentinaEditions Sante2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211952Montiel Centeno, Kiara Yanibeth; Barrera Diaz, Deicy Amparo; García Villén, Fátima; Sánchez Espejo, Rita; Borrego Sánchez, Ana; et al.; Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups; Editions Sante; Journal of Drug Delivery Science and Technology; 72; 103348; 1-2022; 1-431773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2022.103348info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224722002581info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:50Zoai:ri.conicet.gov.ar:11336/211952instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:50.556CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
title Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
spellingShingle Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
Montiel Centeno, Kiara Yanibeth
CEPHALEXIN
DRUG DELIVERY SYSTEM
FUNCTIONALIZATION
KIT-6
LOADING
RELEASE
title_short Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
title_full Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
title_fullStr Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
title_full_unstemmed Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
title_sort Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups
dc.creator.none.fl_str_mv Montiel Centeno, Kiara Yanibeth
Barrera Diaz, Deicy Amparo
García Villén, Fátima
Sánchez Espejo, Rita
Borrego Sánchez, Ana
Castellon, Enrique Rodriguez
Sandri, Giuseppina
Viseras, César
Sapag, Manuel Karim
author Montiel Centeno, Kiara Yanibeth
author_facet Montiel Centeno, Kiara Yanibeth
Barrera Diaz, Deicy Amparo
García Villén, Fátima
Sánchez Espejo, Rita
Borrego Sánchez, Ana
Castellon, Enrique Rodriguez
Sandri, Giuseppina
Viseras, César
Sapag, Manuel Karim
author_role author
author2 Barrera Diaz, Deicy Amparo
García Villén, Fátima
Sánchez Espejo, Rita
Borrego Sánchez, Ana
Castellon, Enrique Rodriguez
Sandri, Giuseppina
Viseras, César
Sapag, Manuel Karim
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CEPHALEXIN
DRUG DELIVERY SYSTEM
FUNCTIONALIZATION
KIT-6
LOADING
RELEASE
topic CEPHALEXIN
DRUG DELIVERY SYSTEM
FUNCTIONALIZATION
KIT-6
LOADING
RELEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv KIT-6 mesoporous silica has been synthesized using the sol-gel method and functionalized with 3-aminopropyl triethoxysilane by grafting route to obtain KIT-6/NH2. These samples were used as carriers in the loading and controlled release of cephalexin (CFX). The effect of temperature and gastric and intestinal pH on the stability of pure CFX and loaded in KIT-6 and KIT-6/NH2 were investigated. The properties of the synthesized materials and their CFX loading capacity were studied through FTIR, ads-des N2 at 77 K, TEM, SEM, XPS, and TGA. The controlled release tests were carried out in a simulated physiological medium at gastric (1.2) and intestinal pH (6.8). Furthermore, the biocompatibility of both materials was studied through cell viability tests in Caco-2 intestinal cells. The results revealed that KIT-6 and KIT-6/NH2 had similar CFX loading capacities. It was found that CFX degrades at pH 6.8, however, KIT-6 and KIT-6/NH2 were able to protect it from the aforementioned degradation. Moreover, KIT-6 materials presented a good performance as CFX carriers since both materials provided diffusion-controlled release profiles during 24 h, satisfying the Korsmeyer-Peppas kinetic model. Mesoporous silicas presented in this work are promising candidates to be used in CFX controlled release systems due to their chemical interactions, textural properties, and high cell viability.
Fil: Montiel Centeno, Kiara Yanibeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: Barrera Diaz, Deicy Amparo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
Fil: García Villén, Fátima. Universidad de Granada. Facultad de Farmacia.; España
Fil: Sánchez Espejo, Rita. Universidad de Granada. Facultad de Farmacia.; España
Fil: Borrego Sánchez, Ana. Universidad de Granada. Facultad de Farmacia.; España
Fil: Castellon, Enrique Rodriguez. Universidad de Málaga; España
Fil: Sandri, Giuseppina. Universita Degli Studi Di Pavia; Italia
Fil: Viseras, César. Universidad de Granada. Facultad de Farmacia.; España
Fil: Sapag, Manuel Karim. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
description KIT-6 mesoporous silica has been synthesized using the sol-gel method and functionalized with 3-aminopropyl triethoxysilane by grafting route to obtain KIT-6/NH2. These samples were used as carriers in the loading and controlled release of cephalexin (CFX). The effect of temperature and gastric and intestinal pH on the stability of pure CFX and loaded in KIT-6 and KIT-6/NH2 were investigated. The properties of the synthesized materials and their CFX loading capacity were studied through FTIR, ads-des N2 at 77 K, TEM, SEM, XPS, and TGA. The controlled release tests were carried out in a simulated physiological medium at gastric (1.2) and intestinal pH (6.8). Furthermore, the biocompatibility of both materials was studied through cell viability tests in Caco-2 intestinal cells. The results revealed that KIT-6 and KIT-6/NH2 had similar CFX loading capacities. It was found that CFX degrades at pH 6.8, however, KIT-6 and KIT-6/NH2 were able to protect it from the aforementioned degradation. Moreover, KIT-6 materials presented a good performance as CFX carriers since both materials provided diffusion-controlled release profiles during 24 h, satisfying the Korsmeyer-Peppas kinetic model. Mesoporous silicas presented in this work are promising candidates to be used in CFX controlled release systems due to their chemical interactions, textural properties, and high cell viability.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211952
Montiel Centeno, Kiara Yanibeth; Barrera Diaz, Deicy Amparo; García Villén, Fátima; Sánchez Espejo, Rita; Borrego Sánchez, Ana; et al.; Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups; Editions Sante; Journal of Drug Delivery Science and Technology; 72; 103348; 1-2022; 1-43
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211952
identifier_str_mv Montiel Centeno, Kiara Yanibeth; Barrera Diaz, Deicy Amparo; García Villén, Fátima; Sánchez Espejo, Rita; Borrego Sánchez, Ana; et al.; Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups; Editions Sante; Journal of Drug Delivery Science and Technology; 72; 103348; 1-2022; 1-43
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2022.103348
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224722002581
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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