Nematodicidal drug combinations: a valid strategy for parasite control in cattle?

Autores
Cantón, Candela; Ceballos, Laura; Moreno Torrejon, Laura; Dominguez, Maria Paula; Cantón, Lucila; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio
Año de publicación
2018
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In an attempt to manage anthelmintic resistance, nematodicidal drug combinations could be considered as a valid strategy to delay resistance development, contributing to optimize control of resistant parasite populations. The rationale behind using combinations is based on the fact that individual worms may have a lower degree of resistance to a multiple component formulation (each chemical with a different mode of action/resistance) compared to that observed when a single anthelmintic molecule is used. A pharmaco-parasitological assessment of different nematodicidal combinations was performed at different cattle commercial farms in Argentina. Ivermectin(IVM)-ricobendazole(RBZ), IVM-levamisole(LEV) and RBZ-LEV combinations were assessed. The observed pharmacokinetic data demonstrated that the co-administration of two anthelmintics did not modify the plasma pharmacokinetic behaviour of either drug in cattle. The combinations were the only treatments achieving 100% clinical efficacy, even when a highly IVM-resistant Haemonchus spp. isolate was present. Overall, after combined treatments a therapeutic additive effect was observed under all susceptible/resistance scenarios. However, the efficacy of IVM-RBZ against nematodes resistant to IVM and RBZ was greater than an additive effect. Achieving the highest possible efficacy is a powerful argument for using combinations; since fewer resistant parasites will survive treatment, the diluting effect with susceptible unselected parasites in refugia will be greater, and thus the development of resistance may be slowed. Additionally, the weight gain was significantly higher for the combination IVM-RBZ in calves naturally infected with resistant nematodes. Overall, anthelmintic combinations could be useful to control gastrointestinal nematodes in cattle farms. However, any treatment decision should be based on a previous diagnosis and rational use of combinations according to the situation of each individual farm.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"
Leon
España
Universidad de León
Materia
Nematodicidal combinations
Anthelmintic resistance
Cattle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173747
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nematodicidal drug combinations: a valid strategy for parasite control in cattle?Cantón, CandelaCeballos, LauraMoreno Torrejon, LauraDominguez, Maria PaulaCantón, LucilaLanusse, Carlos EdmundoAlvarez, Luis IgnacioNematodicidal combinationsAnthelmintic resistanceCattlehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4In an attempt to manage anthelmintic resistance, nematodicidal drug combinations could be considered as a valid strategy to delay resistance development, contributing to optimize control of resistant parasite populations. The rationale behind using combinations is based on the fact that individual worms may have a lower degree of resistance to a multiple component formulation (each chemical with a different mode of action/resistance) compared to that observed when a single anthelmintic molecule is used. A pharmaco-parasitological assessment of different nematodicidal combinations was performed at different cattle commercial farms in Argentina. Ivermectin(IVM)-ricobendazole(RBZ), IVM-levamisole(LEV) and RBZ-LEV combinations were assessed. The observed pharmacokinetic data demonstrated that the co-administration of two anthelmintics did not modify the plasma pharmacokinetic behaviour of either drug in cattle. The combinations were the only treatments achieving 100% clinical efficacy, even when a highly IVM-resistant Haemonchus spp. isolate was present. Overall, after combined treatments a therapeutic additive effect was observed under all susceptible/resistance scenarios. However, the efficacy of IVM-RBZ against nematodes resistant to IVM and RBZ was greater than an additive effect. Achieving the highest possible efficacy is a powerful argument for using combinations; since fewer resistant parasites will survive treatment, the diluting effect with susceptible unselected parasites in refugia will be greater, and thus the development of resistance may be slowed. Additionally, the weight gain was significantly higher for the combination IVM-RBZ in calves naturally infected with resistant nematodes. Overall, anthelmintic combinations could be useful to control gastrointestinal nematodes in cattle farms. However, any treatment decision should be based on a previous diagnosis and rational use of combinations according to the situation of each individual farm.Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"LeonEspañaUniversidad de LeónUniversidad de León2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173747Nematodicidal drug combinations: a valid strategy for parasite control in cattle?; 2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"; Leon; España; 2018; 36-36CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.combar-ca.eu/sites/default/files/COMBAR_WGs%20meeting_Le%C3%B3n%202018_Abstract%20book.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:56Zoai:ri.conicet.gov.ar:11336/173747instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:57.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
title Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
spellingShingle Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
Cantón, Candela
Nematodicidal combinations
Anthelmintic resistance
Cattle
title_short Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
title_full Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
title_fullStr Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
title_full_unstemmed Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
title_sort Nematodicidal drug combinations: a valid strategy for parasite control in cattle?
dc.creator.none.fl_str_mv Cantón, Candela
Ceballos, Laura
Moreno Torrejon, Laura
Dominguez, Maria Paula
Cantón, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author Cantón, Candela
author_facet Cantón, Candela
Ceballos, Laura
Moreno Torrejon, Laura
Dominguez, Maria Paula
Cantón, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author_role author
author2 Ceballos, Laura
Moreno Torrejon, Laura
Dominguez, Maria Paula
Cantón, Lucila
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Nematodicidal combinations
Anthelmintic resistance
Cattle
topic Nematodicidal combinations
Anthelmintic resistance
Cattle
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In an attempt to manage anthelmintic resistance, nematodicidal drug combinations could be considered as a valid strategy to delay resistance development, contributing to optimize control of resistant parasite populations. The rationale behind using combinations is based on the fact that individual worms may have a lower degree of resistance to a multiple component formulation (each chemical with a different mode of action/resistance) compared to that observed when a single anthelmintic molecule is used. A pharmaco-parasitological assessment of different nematodicidal combinations was performed at different cattle commercial farms in Argentina. Ivermectin(IVM)-ricobendazole(RBZ), IVM-levamisole(LEV) and RBZ-LEV combinations were assessed. The observed pharmacokinetic data demonstrated that the co-administration of two anthelmintics did not modify the plasma pharmacokinetic behaviour of either drug in cattle. The combinations were the only treatments achieving 100% clinical efficacy, even when a highly IVM-resistant Haemonchus spp. isolate was present. Overall, after combined treatments a therapeutic additive effect was observed under all susceptible/resistance scenarios. However, the efficacy of IVM-RBZ against nematodes resistant to IVM and RBZ was greater than an additive effect. Achieving the highest possible efficacy is a powerful argument for using combinations; since fewer resistant parasites will survive treatment, the diluting effect with susceptible unselected parasites in refugia will be greater, and thus the development of resistance may be slowed. Additionally, the weight gain was significantly higher for the combination IVM-RBZ in calves naturally infected with resistant nematodes. Overall, anthelmintic combinations could be useful to control gastrointestinal nematodes in cattle farms. However, any treatment decision should be based on a previous diagnosis and rational use of combinations according to the situation of each individual farm.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"
Leon
España
Universidad de León
description In an attempt to manage anthelmintic resistance, nematodicidal drug combinations could be considered as a valid strategy to delay resistance development, contributing to optimize control of resistant parasite populations. The rationale behind using combinations is based on the fact that individual worms may have a lower degree of resistance to a multiple component formulation (each chemical with a different mode of action/resistance) compared to that observed when a single anthelmintic molecule is used. A pharmaco-parasitological assessment of different nematodicidal combinations was performed at different cattle commercial farms in Argentina. Ivermectin(IVM)-ricobendazole(RBZ), IVM-levamisole(LEV) and RBZ-LEV combinations were assessed. The observed pharmacokinetic data demonstrated that the co-administration of two anthelmintics did not modify the plasma pharmacokinetic behaviour of either drug in cattle. The combinations were the only treatments achieving 100% clinical efficacy, even when a highly IVM-resistant Haemonchus spp. isolate was present. Overall, after combined treatments a therapeutic additive effect was observed under all susceptible/resistance scenarios. However, the efficacy of IVM-RBZ against nematodes resistant to IVM and RBZ was greater than an additive effect. Achieving the highest possible efficacy is a powerful argument for using combinations; since fewer resistant parasites will survive treatment, the diluting effect with susceptible unselected parasites in refugia will be greater, and thus the development of resistance may be slowed. Additionally, the weight gain was significantly higher for the combination IVM-RBZ in calves naturally infected with resistant nematodes. Overall, anthelmintic combinations could be useful to control gastrointestinal nematodes in cattle farms. However, any treatment decision should be based on a previous diagnosis and rational use of combinations according to the situation of each individual farm.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173747
Nematodicidal drug combinations: a valid strategy for parasite control in cattle?; 2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"; Leon; España; 2018; 36-36
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173747
identifier_str_mv Nematodicidal drug combinations: a valid strategy for parasite control in cattle?; 2nd COMBAR Working Groups Meeting. Anthelmintic resistance: past, present and future"; Leon; España; 2018; 36-36
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Universidad de León
publisher.none.fl_str_mv Universidad de León
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