Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population

Autores
Dieguez, S. M.; Cnepa, C. A.; Amorena, Carlos Ernesto
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background/Aims: The effect of angiotensin-converting enzyme inhibition (ACEi) is amply documented in several pathological conditions. However, there are few reports about the effect of chronic ACEi on salt and water balance. The present work evaluates the effect of chronic ACEi on salt and water balance in a population of children receiving enalapril chronically in order to reduce albuminuria elicited by a uremic hemolytic syndrome. Methods: Nine children aged from 9 to 19 years with normal glomerular filtration rate, normotension and with urinary concentration capacity preserved were treated with enalapril with doses ranging between 0.1 and 0.30 mg/kg/day. Diuresis, urinary absolute and fractional excretion of Na+, K+ and urea, creatinine clearance, osmolal clearance and tubular water reabsorption were measured under three experimental procedures: (1) with free access to water; (2) with a water load and (3) with water restriction. In the last group urinary antidiuretic hormone (ADH) was measured. These tests were performed in a paired way, just before starting ACEi treatment and after 6 months of enalapril treatment. Results: Enalapril treatment diminished the urinary concentration capacity without affecting Na+ and K+ urinary excretion. Creatinine clearance was not modified except in the condition of water load where a fall in it was found after ACEi. ADH increased after enalapril treatment in children under water restriction. Conclusion: In these children chronic ACEi decreases urinary concentration capacity.
Fil: Dieguez, S. M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Cnepa, C. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Amorena, Carlos Ernesto. Universidad Nacional de General San Martn; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANGIOTENSIN-CONVERTING ENZYME INHIBITION
PEDIATRIC PATIENTS
RENAL SALT AND WATER BALANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194721
Acceder
id CONICETDig_e03b1eb801a5c6e4120990f28ffe6cf4
oai_identifier_str oai:ri.conicet.gov.ar:11336/194721
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric PopulationDieguez, S. M.Cnepa, C. A.Amorena, Carlos ErnestoANGIOTENSIN-CONVERTING ENZYME INHIBITIONPEDIATRIC PATIENTSRENAL SALT AND WATER BALANCEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background/Aims: The effect of angiotensin-converting enzyme inhibition (ACEi) is amply documented in several pathological conditions. However, there are few reports about the effect of chronic ACEi on salt and water balance. The present work evaluates the effect of chronic ACEi on salt and water balance in a population of children receiving enalapril chronically in order to reduce albuminuria elicited by a uremic hemolytic syndrome. Methods: Nine children aged from 9 to 19 years with normal glomerular filtration rate, normotension and with urinary concentration capacity preserved were treated with enalapril with doses ranging between 0.1 and 0.30 mg/kg/day. Diuresis, urinary absolute and fractional excretion of Na+, K+ and urea, creatinine clearance, osmolal clearance and tubular water reabsorption were measured under three experimental procedures: (1) with free access to water; (2) with a water load and (3) with water restriction. In the last group urinary antidiuretic hormone (ADH) was measured. These tests were performed in a paired way, just before starting ACEi treatment and after 6 months of enalapril treatment. Results: Enalapril treatment diminished the urinary concentration capacity without affecting Na+ and K+ urinary excretion. Creatinine clearance was not modified except in the condition of water load where a fall in it was found after ACEi. ADH increased after enalapril treatment in children under water restriction. Conclusion: In these children chronic ACEi decreases urinary concentration capacity.Fil: Dieguez, S. M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Cnepa, C. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Amorena, Carlos Ernesto. Universidad Nacional de General San Martn; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaKarger2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194721Dieguez, S. M.; Cnepa, C. A.; Amorena, Carlos Ernesto; Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population; Karger; Pharmacology; 89; 5-6; 6-2012; 321-3260031-7012CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/334624info:eu-repo/semantics/altIdentifier/doi/10.1159/000334624info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:02Zoai:ri.conicet.gov.ar:11336/194721instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:02.328CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
title Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
spellingShingle Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
Dieguez, S. M.
ANGIOTENSIN-CONVERTING ENZYME INHIBITION
PEDIATRIC PATIENTS
RENAL SALT AND WATER BALANCE
title_short Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
title_full Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
title_fullStr Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
title_full_unstemmed Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
title_sort Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population
dc.creator.none.fl_str_mv Dieguez, S. M.
Cnepa, C. A.
Amorena, Carlos Ernesto
author Dieguez, S. M.
author_facet Dieguez, S. M.
Cnepa, C. A.
Amorena, Carlos Ernesto
author_role author
author2 Cnepa, C. A.
Amorena, Carlos Ernesto
author2_role author
author
dc.subject.none.fl_str_mv ANGIOTENSIN-CONVERTING ENZYME INHIBITION
PEDIATRIC PATIENTS
RENAL SALT AND WATER BALANCE
topic ANGIOTENSIN-CONVERTING ENZYME INHIBITION
PEDIATRIC PATIENTS
RENAL SALT AND WATER BALANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background/Aims: The effect of angiotensin-converting enzyme inhibition (ACEi) is amply documented in several pathological conditions. However, there are few reports about the effect of chronic ACEi on salt and water balance. The present work evaluates the effect of chronic ACEi on salt and water balance in a population of children receiving enalapril chronically in order to reduce albuminuria elicited by a uremic hemolytic syndrome. Methods: Nine children aged from 9 to 19 years with normal glomerular filtration rate, normotension and with urinary concentration capacity preserved were treated with enalapril with doses ranging between 0.1 and 0.30 mg/kg/day. Diuresis, urinary absolute and fractional excretion of Na+, K+ and urea, creatinine clearance, osmolal clearance and tubular water reabsorption were measured under three experimental procedures: (1) with free access to water; (2) with a water load and (3) with water restriction. In the last group urinary antidiuretic hormone (ADH) was measured. These tests were performed in a paired way, just before starting ACEi treatment and after 6 months of enalapril treatment. Results: Enalapril treatment diminished the urinary concentration capacity without affecting Na+ and K+ urinary excretion. Creatinine clearance was not modified except in the condition of water load where a fall in it was found after ACEi. ADH increased after enalapril treatment in children under water restriction. Conclusion: In these children chronic ACEi decreases urinary concentration capacity.
Fil: Dieguez, S. M.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Cnepa, C. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina
Fil: Amorena, Carlos Ernesto. Universidad Nacional de General San Martn; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background/Aims: The effect of angiotensin-converting enzyme inhibition (ACEi) is amply documented in several pathological conditions. However, there are few reports about the effect of chronic ACEi on salt and water balance. The present work evaluates the effect of chronic ACEi on salt and water balance in a population of children receiving enalapril chronically in order to reduce albuminuria elicited by a uremic hemolytic syndrome. Methods: Nine children aged from 9 to 19 years with normal glomerular filtration rate, normotension and with urinary concentration capacity preserved were treated with enalapril with doses ranging between 0.1 and 0.30 mg/kg/day. Diuresis, urinary absolute and fractional excretion of Na+, K+ and urea, creatinine clearance, osmolal clearance and tubular water reabsorption were measured under three experimental procedures: (1) with free access to water; (2) with a water load and (3) with water restriction. In the last group urinary antidiuretic hormone (ADH) was measured. These tests were performed in a paired way, just before starting ACEi treatment and after 6 months of enalapril treatment. Results: Enalapril treatment diminished the urinary concentration capacity without affecting Na+ and K+ urinary excretion. Creatinine clearance was not modified except in the condition of water load where a fall in it was found after ACEi. ADH increased after enalapril treatment in children under water restriction. Conclusion: In these children chronic ACEi decreases urinary concentration capacity.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194721
Dieguez, S. M.; Cnepa, C. A.; Amorena, Carlos Ernesto; Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population; Karger; Pharmacology; 89; 5-6; 6-2012; 321-326
0031-7012
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194721
identifier_str_mv Dieguez, S. M.; Cnepa, C. A.; Amorena, Carlos Ernesto; Effect of Chronic Inhibition of Converting Enzyme on Renal Handling of Salt and Water: A Study on a Pediatric Population; Karger; Pharmacology; 89; 5-6; 6-2012; 321-326
0031-7012
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/334624
info:eu-repo/semantics/altIdentifier/doi/10.1159/000334624
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269496514969600
score 13.13397

Publicaciones similares