Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme

Autores
Giani, Jorge Fernando; Bernstein, Kenneth E.; Janjulia, Tea; Han, Jiyang; Toblli, Jorge Eduardo; Shen, Xiao Z.; Rodriguez Iturbe, Bernardo; McDonough, Alicia A.; Gonzalez Villalobos, Romer A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recent evidence indicates that salt-sensitive hypertension can result from a subclinical injury that impairs the kidneys´ capacity to properly respond to a high-salt diet. However, how this occurs is not well understood. Here, we showed that although previously salt-resistant wild-type mice became salt sensitive after the induction of renal injury with the nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester hydrochloride; mice lacking renal angiotensin-converting enzyme, exposed to the same insult, did not become hypertensive when faced with a sodium load. This is because the activity of renal angiotensin-converting enzyme plays a critical role in (1) augmenting the local pool of angiotensin II and (2) the establishment of the antinatriuretic state via modulation of glomerular filtration rate and sodium tubular transport. Thus, this study demonstrates that the presence of renal angiotensin-converting enzyme plays a pivotal role in the development of salt sensitivity in response to renal injury.
Fil: Giani, Jorge Fernando. Cedars Sinai Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernstein, Kenneth E.. Cedars Sinai Medical Center; Estados Unidos
Fil: Janjulia, Tea. Cedars Sinai Medical Center; Estados Unidos
Fil: Han, Jiyang. Keck School Of Medicine Of Usc; . University of Southern California; Estados Unidos
Fil: Toblli, Jorge Eduardo. Universidad de Buenos Aires; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Shen, Xiao Z.. Cedars Sinai Medical Center; Estados Unidos
Fil: Rodriguez Iturbe, Bernardo. Cedars Sinai Medical Center; Estados Unidos. Hospital Universitario de Maracaibo; Venezuela
Fil: McDonough, Alicia A.. University of Southern California; Estados Unidos
Fil: Gonzalez Villalobos, Romer A.. Cedars Sinai Medical Center; Estados Unidos
Materia
Angiotensin-Converting Enzyme
Diet
Glomerular Filtration Rate
Hypertension
Inflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21485
Acceder
id CONICETDig_64318d93eeb47e7c438dadd97d2b5c1f
oai_identifier_str oai:ri.conicet.gov.ar:11336/21485
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Salt sensitivity in response to renal injury requires renal angiotensin-converting enzymeGiani, Jorge FernandoBernstein, Kenneth E.Janjulia, TeaHan, JiyangToblli, Jorge EduardoShen, Xiao Z.Rodriguez Iturbe, BernardoMcDonough, Alicia A.Gonzalez Villalobos, Romer A.Angiotensin-Converting EnzymeDietGlomerular Filtration RateHypertensionInflammationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Recent evidence indicates that salt-sensitive hypertension can result from a subclinical injury that impairs the kidneys´ capacity to properly respond to a high-salt diet. However, how this occurs is not well understood. Here, we showed that although previously salt-resistant wild-type mice became salt sensitive after the induction of renal injury with the nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester hydrochloride; mice lacking renal angiotensin-converting enzyme, exposed to the same insult, did not become hypertensive when faced with a sodium load. This is because the activity of renal angiotensin-converting enzyme plays a critical role in (1) augmenting the local pool of angiotensin II and (2) the establishment of the antinatriuretic state via modulation of glomerular filtration rate and sodium tubular transport. Thus, this study demonstrates that the presence of renal angiotensin-converting enzyme plays a pivotal role in the development of salt sensitivity in response to renal injury.Fil: Giani, Jorge Fernando. Cedars Sinai Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bernstein, Kenneth E.. Cedars Sinai Medical Center; Estados UnidosFil: Janjulia, Tea. Cedars Sinai Medical Center; Estados UnidosFil: Han, Jiyang. Keck School Of Medicine Of Usc; . University of Southern California; Estados UnidosFil: Toblli, Jorge Eduardo. Universidad de Buenos Aires; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Shen, Xiao Z.. Cedars Sinai Medical Center; Estados UnidosFil: Rodriguez Iturbe, Bernardo. Cedars Sinai Medical Center; Estados Unidos. Hospital Universitario de Maracaibo; VenezuelaFil: McDonough, Alicia A.. University of Southern California; Estados UnidosFil: Gonzalez Villalobos, Romer A.. Cedars Sinai Medical Center; Estados UnidosAmerican Heart Association2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21485Giani, Jorge Fernando; Bernstein, Kenneth E.; Janjulia, Tea; Han, Jiyang; Toblli, Jorge Eduardo; et al.; Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme; American Heart Association; Hypertension; 66; 3; 9-2015; 534-5420194-911Xenginfo:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.115.05320info:eu-repo/semantics/altIdentifier/url/http://hyper.ahajournals.org/content/66/3/534info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:32Zoai:ri.conicet.gov.ar:11336/21485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:32.534CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
title Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
spellingShingle Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
Giani, Jorge Fernando
Angiotensin-Converting Enzyme
Diet
Glomerular Filtration Rate
Hypertension
Inflammation
title_short Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
title_full Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
title_fullStr Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
title_full_unstemmed Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
title_sort Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme
dc.creator.none.fl_str_mv Giani, Jorge Fernando
Bernstein, Kenneth E.
Janjulia, Tea
Han, Jiyang
Toblli, Jorge Eduardo
Shen, Xiao Z.
Rodriguez Iturbe, Bernardo
McDonough, Alicia A.
Gonzalez Villalobos, Romer A.
author Giani, Jorge Fernando
author_facet Giani, Jorge Fernando
Bernstein, Kenneth E.
Janjulia, Tea
Han, Jiyang
Toblli, Jorge Eduardo
Shen, Xiao Z.
Rodriguez Iturbe, Bernardo
McDonough, Alicia A.
Gonzalez Villalobos, Romer A.
author_role author
author2 Bernstein, Kenneth E.
Janjulia, Tea
Han, Jiyang
Toblli, Jorge Eduardo
Shen, Xiao Z.
Rodriguez Iturbe, Bernardo
McDonough, Alicia A.
Gonzalez Villalobos, Romer A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Angiotensin-Converting Enzyme
Diet
Glomerular Filtration Rate
Hypertension
Inflammation
topic Angiotensin-Converting Enzyme
Diet
Glomerular Filtration Rate
Hypertension
Inflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recent evidence indicates that salt-sensitive hypertension can result from a subclinical injury that impairs the kidneys´ capacity to properly respond to a high-salt diet. However, how this occurs is not well understood. Here, we showed that although previously salt-resistant wild-type mice became salt sensitive after the induction of renal injury with the nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester hydrochloride; mice lacking renal angiotensin-converting enzyme, exposed to the same insult, did not become hypertensive when faced with a sodium load. This is because the activity of renal angiotensin-converting enzyme plays a critical role in (1) augmenting the local pool of angiotensin II and (2) the establishment of the antinatriuretic state via modulation of glomerular filtration rate and sodium tubular transport. Thus, this study demonstrates that the presence of renal angiotensin-converting enzyme plays a pivotal role in the development of salt sensitivity in response to renal injury.
Fil: Giani, Jorge Fernando. Cedars Sinai Medical Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernstein, Kenneth E.. Cedars Sinai Medical Center; Estados Unidos
Fil: Janjulia, Tea. Cedars Sinai Medical Center; Estados Unidos
Fil: Han, Jiyang. Keck School Of Medicine Of Usc; . University of Southern California; Estados Unidos
Fil: Toblli, Jorge Eduardo. Universidad de Buenos Aires; Argentina. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Shen, Xiao Z.. Cedars Sinai Medical Center; Estados Unidos
Fil: Rodriguez Iturbe, Bernardo. Cedars Sinai Medical Center; Estados Unidos. Hospital Universitario de Maracaibo; Venezuela
Fil: McDonough, Alicia A.. University of Southern California; Estados Unidos
Fil: Gonzalez Villalobos, Romer A.. Cedars Sinai Medical Center; Estados Unidos
description Recent evidence indicates that salt-sensitive hypertension can result from a subclinical injury that impairs the kidneys´ capacity to properly respond to a high-salt diet. However, how this occurs is not well understood. Here, we showed that although previously salt-resistant wild-type mice became salt sensitive after the induction of renal injury with the nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester hydrochloride; mice lacking renal angiotensin-converting enzyme, exposed to the same insult, did not become hypertensive when faced with a sodium load. This is because the activity of renal angiotensin-converting enzyme plays a critical role in (1) augmenting the local pool of angiotensin II and (2) the establishment of the antinatriuretic state via modulation of glomerular filtration rate and sodium tubular transport. Thus, this study demonstrates that the presence of renal angiotensin-converting enzyme plays a pivotal role in the development of salt sensitivity in response to renal injury.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21485
Giani, Jorge Fernando; Bernstein, Kenneth E.; Janjulia, Tea; Han, Jiyang; Toblli, Jorge Eduardo; et al.; Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme; American Heart Association; Hypertension; 66; 3; 9-2015; 534-542
0194-911X
url http://hdl.handle.net/11336/21485
identifier_str_mv Giani, Jorge Fernando; Bernstein, Kenneth E.; Janjulia, Tea; Han, Jiyang; Toblli, Jorge Eduardo; et al.; Salt sensitivity in response to renal injury requires renal angiotensin-converting enzyme; American Heart Association; Hypertension; 66; 3; 9-2015; 534-542
0194-911X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.115.05320
info:eu-repo/semantics/altIdentifier/url/http://hyper.ahajournals.org/content/66/3/534
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269644228919296
score 13.13397

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