Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans

Autores
Gonzales Moreno, Candelaria; Fernandez Hubeid, Lucia Eugenia; Holgado, Andrea; Virgolini, Miriam Beatriz
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exposure to the herbicide paraquat (PQ; 1,1′-dimethyl-4,4′-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in Caenorhabditis elegans after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.
Fil: Gonzales Moreno, Candelaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Fernandez Hubeid, Lucia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Holgado, Andrea. Saint Edwards University; Estados Unidos
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Materia
C ELEGANS
PARAQUAT
N ACETYL CYSTEINE
MORTALITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230573
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gansGonzales Moreno, CandelariaFernandez Hubeid, Lucia EugeniaHolgado, AndreaVirgolini, Miriam BeatrizC ELEGANSPARAQUATN ACETYL CYSTEINEMORTALITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Exposure to the herbicide paraquat (PQ; 1,1′-dimethyl-4,4′-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in Caenorhabditis elegans after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.Fil: Gonzales Moreno, Candelaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Fernandez Hubeid, Lucia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Holgado, Andrea. Saint Edwards University; Estados UnidosFil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaCalTech Library2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230573Gonzales Moreno, Candelaria; Fernandez Hubeid, Lucia Eugenia; Holgado, Andrea; Virgolini, Miriam Beatriz; Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans; CalTech Library; microPublication Biology; 2023; 3-2023; 1-62578-9430CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.micropublication.org/journals/biology/micropub-biology-000815info:eu-repo/semantics/altIdentifier/doi/10.17912/micropub.biology.000815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:03Zoai:ri.conicet.gov.ar:11336/230573instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:03.329CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
title Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
spellingShingle Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
Gonzales Moreno, Candelaria
C ELEGANS
PARAQUAT
N ACETYL CYSTEINE
MORTALITY
title_short Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
title_full Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
title_fullStr Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
title_full_unstemmed Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
title_sort Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans
dc.creator.none.fl_str_mv Gonzales Moreno, Candelaria
Fernandez Hubeid, Lucia Eugenia
Holgado, Andrea
Virgolini, Miriam Beatriz
author Gonzales Moreno, Candelaria
author_facet Gonzales Moreno, Candelaria
Fernandez Hubeid, Lucia Eugenia
Holgado, Andrea
Virgolini, Miriam Beatriz
author_role author
author2 Fernandez Hubeid, Lucia Eugenia
Holgado, Andrea
Virgolini, Miriam Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv C ELEGANS
PARAQUAT
N ACETYL CYSTEINE
MORTALITY
topic C ELEGANS
PARAQUAT
N ACETYL CYSTEINE
MORTALITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Exposure to the herbicide paraquat (PQ; 1,1′-dimethyl-4,4′-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in Caenorhabditis elegans after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.
Fil: Gonzales Moreno, Candelaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Fernandez Hubeid, Lucia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Holgado, Andrea. Saint Edwards University; Estados Unidos
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
description Exposure to the herbicide paraquat (PQ; 1,1′-dimethyl-4,4′-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in Caenorhabditis elegans after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230573
Gonzales Moreno, Candelaria; Fernandez Hubeid, Lucia Eugenia; Holgado, Andrea; Virgolini, Miriam Beatriz; Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans; CalTech Library; microPublication Biology; 2023; 3-2023; 1-6
2578-9430
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230573
identifier_str_mv Gonzales Moreno, Candelaria; Fernandez Hubeid, Lucia Eugenia; Holgado, Andrea; Virgolini, Miriam Beatriz; Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis ele-gans; CalTech Library; microPublication Biology; 2023; 3-2023; 1-6
2578-9430
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.micropublication.org/journals/biology/micropub-biology-000815
info:eu-repo/semantics/altIdentifier/doi/10.17912/micropub.biology.000815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv CalTech Library
publisher.none.fl_str_mv CalTech Library
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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