Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity

Autores
Bujan, Ariana; Alonso, Silvia del Valle; Chiaramoni, Nadia Silvia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture as NAC delivery systems, with a possible dose reduction but maintaining its effect.Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity.Lipids belonging to lung surfactant were added in different ratios to the formulations in order to maximize itspossible interaction with the lung tissue. Because of lipopolymer stability, the oral or nasal route could beappropriated. This formulation could efficiently transport NAC to exert its mucolytic activity and help in diseasessuch as cystic fibrosis, which has abnormal mucus production. Also, this type of treatment could be useful inother types of diseases, interacting with the mucus layer and making the lung tissue more permeable to othertherapies.Formulations so obtained presented high levels of polymerization. Also, they present small hollow fibersstructures with a high number of polymeric units. These types of arrangements could present advantages in thefield of drug delivery, giving the possibility of a controlled release. Lipopolymers with lipids from lung surfactantassociated with NAC are promising complexes in order to treat not only respiratory illnesses. The stability of theformulation would allow its inoculation through other routes such as the oral one, helping the reposition of NACas an antioxidant drug. Finally, these formulations are non-toxic and easy to produce.
Fil: Bujan, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Alonso, Silvia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Chiaramoni, Nadia Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Materia
LIPOPOLYMERS
N-ACETYL-L-CYSTEINE
LUNGS
MUCOLYTICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/154373
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/154373
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicityBujan, ArianaAlonso, Silvia del ValleChiaramoni, Nadia SilviaLIPOPOLYMERSN-ACETYL-L-CYSTEINELUNGSMUCOLYTICShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture as NAC delivery systems, with a possible dose reduction but maintaining its effect.Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity.Lipids belonging to lung surfactant were added in different ratios to the formulations in order to maximize itspossible interaction with the lung tissue. Because of lipopolymer stability, the oral or nasal route could beappropriated. This formulation could efficiently transport NAC to exert its mucolytic activity and help in diseasessuch as cystic fibrosis, which has abnormal mucus production. Also, this type of treatment could be useful inother types of diseases, interacting with the mucus layer and making the lung tissue more permeable to othertherapies.Formulations so obtained presented high levels of polymerization. Also, they present small hollow fibersstructures with a high number of polymeric units. These types of arrangements could present advantages in thefield of drug delivery, giving the possibility of a controlled release. Lipopolymers with lipids from lung surfactantassociated with NAC are promising complexes in order to treat not only respiratory illnesses. The stability of theformulation would allow its inoculation through other routes such as the oral one, helping the reposition of NACas an antioxidant drug. Finally, these formulations are non-toxic and easy to produce.Fil: Bujan, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Alonso, Silvia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Chiaramoni, Nadia Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaElsevier Ireland2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154373Bujan, Ariana; Alonso, Silvia del Valle; Chiaramoni, Nadia Silvia; Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity; Elsevier Ireland; Chemistry and Physics of Lipids; 231; 104936; 9-2020; 1-80009-3084CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.chemphyslip.2020.104936info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009308420300670info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:07:46Zoai:ri.conicet.gov.ar:11336/154373instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:07:47.103CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
title Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
spellingShingle Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
Bujan, Ariana
LIPOPOLYMERS
N-ACETYL-L-CYSTEINE
LUNGS
MUCOLYTICS
title_short Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
title_full Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
title_fullStr Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
title_full_unstemmed Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
title_sort Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity
dc.creator.none.fl_str_mv Bujan, Ariana
Alonso, Silvia del Valle
Chiaramoni, Nadia Silvia
author Bujan, Ariana
author_facet Bujan, Ariana
Alonso, Silvia del Valle
Chiaramoni, Nadia Silvia
author_role author
author2 Alonso, Silvia del Valle
Chiaramoni, Nadia Silvia
author2_role author
author
dc.subject.none.fl_str_mv LIPOPOLYMERS
N-ACETYL-L-CYSTEINE
LUNGS
MUCOLYTICS
topic LIPOPOLYMERS
N-ACETYL-L-CYSTEINE
LUNGS
MUCOLYTICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture as NAC delivery systems, with a possible dose reduction but maintaining its effect.Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity.Lipids belonging to lung surfactant were added in different ratios to the formulations in order to maximize itspossible interaction with the lung tissue. Because of lipopolymer stability, the oral or nasal route could beappropriated. This formulation could efficiently transport NAC to exert its mucolytic activity and help in diseasessuch as cystic fibrosis, which has abnormal mucus production. Also, this type of treatment could be useful inother types of diseases, interacting with the mucus layer and making the lung tissue more permeable to othertherapies.Formulations so obtained presented high levels of polymerization. Also, they present small hollow fibersstructures with a high number of polymeric units. These types of arrangements could present advantages in thefield of drug delivery, giving the possibility of a controlled release. Lipopolymers with lipids from lung surfactantassociated with NAC are promising complexes in order to treat not only respiratory illnesses. The stability of theformulation would allow its inoculation through other routes such as the oral one, helping the reposition of NACas an antioxidant drug. Finally, these formulations are non-toxic and easy to produce.
Fil: Bujan, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Alonso, Silvia del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Chiaramoni, Nadia Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
description In the present work, we obtained polymeric diacetylene liposomes that can associate N-Acetyl-L-Cysteine (NAC),a broad spectrum mucolytic. The reason for studying these formulations is that they could be applied in thefuture as NAC delivery systems, with a possible dose reduction but maintaining its effect.Liposomes used herein are obtained by a photopolymerization reaction, thus gaining stability and rigidity.Lipids belonging to lung surfactant were added in different ratios to the formulations in order to maximize itspossible interaction with the lung tissue. Because of lipopolymer stability, the oral or nasal route could beappropriated. This formulation could efficiently transport NAC to exert its mucolytic activity and help in diseasessuch as cystic fibrosis, which has abnormal mucus production. Also, this type of treatment could be useful inother types of diseases, interacting with the mucus layer and making the lung tissue more permeable to othertherapies.Formulations so obtained presented high levels of polymerization. Also, they present small hollow fibersstructures with a high number of polymeric units. These types of arrangements could present advantages in thefield of drug delivery, giving the possibility of a controlled release. Lipopolymers with lipids from lung surfactantassociated with NAC are promising complexes in order to treat not only respiratory illnesses. The stability of theformulation would allow its inoculation through other routes such as the oral one, helping the reposition of NACas an antioxidant drug. Finally, these formulations are non-toxic and easy to produce.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/154373
Bujan, Ariana; Alonso, Silvia del Valle; Chiaramoni, Nadia Silvia; Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity; Elsevier Ireland; Chemistry and Physics of Lipids; 231; 104936; 9-2020; 1-8
0009-3084
CONICET Digital
CONICET
url http://hdl.handle.net/11336/154373
identifier_str_mv Bujan, Ariana; Alonso, Silvia del Valle; Chiaramoni, Nadia Silvia; Lipopolymers and lipids from lung surfactants in association with N-acetyl-l-cysteine: Characterization and cytotoxicity; Elsevier Ireland; Chemistry and Physics of Lipids; 231; 104936; 9-2020; 1-8
0009-3084
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.chemphyslip.2020.104936
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0009308420300670
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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