Grinding effect on levofloxacin hemihydrate

Autores
Pereira, Rafael Nicolay; Fandaruff, Cinira; Riekes, Manoela Klüppel; Monti, Gustavo Alberto; De Campos, Carlos Eduardo Maduro; Cuffini, Silvia Lucia; Silva, Marcos Antonio Segatto
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.
Fil: Pereira, Rafael Nicolay. Universidade Federal de Santa Catarina; Brasil
Fil: Fandaruff, Cinira. Universidade Federal de Santa Catarina; Brasil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: De Campos, Carlos Eduardo Maduro. Universidade Federal de Santa Catarina; Brasil
Fil: Cuffini, Silvia Lucia. Universidade Federal de Sao Paulo; Brasil. Universidade Federal de Santa Catarina; Brasil
Fil: Silva, Marcos Antonio Segatto. Universidade Federal de Santa Catarina; Brasil
Materia
GRINDING
HEMIHYDRATE
LEVOFLOXACIN
REHYDRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185833
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Grinding effect on levofloxacin hemihydratePereira, Rafael NicolayFandaruff, CiniraRiekes, Manoela KlüppelMonti, Gustavo AlbertoDe Campos, Carlos Eduardo MaduroCuffini, Silvia LuciaSilva, Marcos Antonio SegattoGRINDINGHEMIHYDRATELEVOFLOXACINREHYDRATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.Fil: Pereira, Rafael Nicolay. Universidade Federal de Santa Catarina; BrasilFil: Fandaruff, Cinira. Universidade Federal de Santa Catarina; BrasilFil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: De Campos, Carlos Eduardo Maduro. Universidade Federal de Santa Catarina; BrasilFil: Cuffini, Silvia Lucia. Universidade Federal de Sao Paulo; Brasil. Universidade Federal de Santa Catarina; BrasilFil: Silva, Marcos Antonio Segatto. Universidade Federal de Santa Catarina; BrasilSpringer2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185833Pereira, Rafael Nicolay; Fandaruff, Cinira; Riekes, Manoela Klüppel; Monti, Gustavo Alberto; De Campos, Carlos Eduardo Maduro; et al.; Grinding effect on levofloxacin hemihydrate; Springer; Journal of Thermal Analysis and Calorimetry; 119; 2; 2-2015; 989-9941388-61501588-2926CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10973-014-4233-1info:eu-repo/semantics/altIdentifier/doi/10.1007/s10973-014-4233-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:19:00Zoai:ri.conicet.gov.ar:11336/185833instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:19:00.433CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Grinding effect on levofloxacin hemihydrate
title Grinding effect on levofloxacin hemihydrate
spellingShingle Grinding effect on levofloxacin hemihydrate
Pereira, Rafael Nicolay
GRINDING
HEMIHYDRATE
LEVOFLOXACIN
REHYDRATION
title_short Grinding effect on levofloxacin hemihydrate
title_full Grinding effect on levofloxacin hemihydrate
title_fullStr Grinding effect on levofloxacin hemihydrate
title_full_unstemmed Grinding effect on levofloxacin hemihydrate
title_sort Grinding effect on levofloxacin hemihydrate
dc.creator.none.fl_str_mv Pereira, Rafael Nicolay
Fandaruff, Cinira
Riekes, Manoela Klüppel
Monti, Gustavo Alberto
De Campos, Carlos Eduardo Maduro
Cuffini, Silvia Lucia
Silva, Marcos Antonio Segatto
author Pereira, Rafael Nicolay
author_facet Pereira, Rafael Nicolay
Fandaruff, Cinira
Riekes, Manoela Klüppel
Monti, Gustavo Alberto
De Campos, Carlos Eduardo Maduro
Cuffini, Silvia Lucia
Silva, Marcos Antonio Segatto
author_role author
author2 Fandaruff, Cinira
Riekes, Manoela Klüppel
Monti, Gustavo Alberto
De Campos, Carlos Eduardo Maduro
Cuffini, Silvia Lucia
Silva, Marcos Antonio Segatto
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv GRINDING
HEMIHYDRATE
LEVOFLOXACIN
REHYDRATION
topic GRINDING
HEMIHYDRATE
LEVOFLOXACIN
REHYDRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.
Fil: Pereira, Rafael Nicolay. Universidade Federal de Santa Catarina; Brasil
Fil: Fandaruff, Cinira. Universidade Federal de Santa Catarina; Brasil
Fil: Riekes, Manoela Klüppel. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: De Campos, Carlos Eduardo Maduro. Universidade Federal de Santa Catarina; Brasil
Fil: Cuffini, Silvia Lucia. Universidade Federal de Sao Paulo; Brasil. Universidade Federal de Santa Catarina; Brasil
Fil: Silva, Marcos Antonio Segatto. Universidade Federal de Santa Catarina; Brasil
description The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185833
Pereira, Rafael Nicolay; Fandaruff, Cinira; Riekes, Manoela Klüppel; Monti, Gustavo Alberto; De Campos, Carlos Eduardo Maduro; et al.; Grinding effect on levofloxacin hemihydrate; Springer; Journal of Thermal Analysis and Calorimetry; 119; 2; 2-2015; 989-994
1388-6150
1588-2926
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185833
identifier_str_mv Pereira, Rafael Nicolay; Fandaruff, Cinira; Riekes, Manoela Klüppel; Monti, Gustavo Alberto; De Campos, Carlos Eduardo Maduro; et al.; Grinding effect on levofloxacin hemihydrate; Springer; Journal of Thermal Analysis and Calorimetry; 119; 2; 2-2015; 989-994
1388-6150
1588-2926
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s10973-014-4233-1
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10973-014-4233-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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