Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum

Autores
Belluscio, Mariano Andres; Escande, Mariela Veronica; Keifman, Ettel; Riquelme, Luis Alberto; Murer, Mario Gustavo; Zold, Camila Lidia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In animal models of Parkinson´s disease cortical oscillations entrain abnormal synchronous rhythms in basal ganglia neurons. A mechanism accounting for these oscillations should: (i) vindicate a key role of the striatum in Parkinson´s disease pathophysiology by considering how alterations in striatal physiology may gate cortico-basal ganglia oscillations; (ii) explain why abnormal basal ganglia oscillations span the whole frequency range of oscillations observed in the normal frontal cortex; and (iii) provide insight into how these oscillations may relate to akinesia. Here we update our proposal that striatal projection neurons (medium spiny neurons) behave as dopamine-dependent filters which normally do not allow the propagation of resting cortical activity through the basal ganglia circuit. After chronic dopamine depletion, cortical oscillations would spread through more excitable medium spiny neurons to entrain the whole indirect pathway. Therefore, akinesia may not be directly related to oscillations, but to the inability of medium spiny neurons to separate salient pieces of cortical information from the ongoing cortical rhythms they are embedded in. We propose that uncontrolled translation of ongoing cortical activity into no-go signals in the indirect pathway induces akinesia. Thus, oscillations would be an extreme manifestation of this excessive permeability of medium spiny neurons to cortical input in advanced stages of Parkinson´s disease.
Fil: Belluscio, Mariano Andres. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Keifman, Ettel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Riquelme, Luis Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Parkinson'S Disease
Striatum
Oscillations
Synchronization
Globus Pallidus
Indirect Pathway
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31779
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31779
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Oscillations in the basal ganglia in Parkinson's disease: Role of the striatumBelluscio, Mariano AndresEscande, Mariela VeronicaKeifman, EttelRiquelme, Luis AlbertoMurer, Mario GustavoZold, Camila LidiaParkinson'S DiseaseStriatumOscillationsSynchronizationGlobus PallidusIndirect Pathwayhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In animal models of Parkinson´s disease cortical oscillations entrain abnormal synchronous rhythms in basal ganglia neurons. A mechanism accounting for these oscillations should: (i) vindicate a key role of the striatum in Parkinson´s disease pathophysiology by considering how alterations in striatal physiology may gate cortico-basal ganglia oscillations; (ii) explain why abnormal basal ganglia oscillations span the whole frequency range of oscillations observed in the normal frontal cortex; and (iii) provide insight into how these oscillations may relate to akinesia. Here we update our proposal that striatal projection neurons (medium spiny neurons) behave as dopamine-dependent filters which normally do not allow the propagation of resting cortical activity through the basal ganglia circuit. After chronic dopamine depletion, cortical oscillations would spread through more excitable medium spiny neurons to entrain the whole indirect pathway. Therefore, akinesia may not be directly related to oscillations, but to the inability of medium spiny neurons to separate salient pieces of cortical information from the ongoing cortical rhythms they are embedded in. We propose that uncontrolled translation of ongoing cortical activity into no-go signals in the indirect pathway induces akinesia. Thus, oscillations would be an extreme manifestation of this excessive permeability of medium spiny neurons to cortical input in advanced stages of Parkinson´s disease.Fil: Belluscio, Mariano Andres. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Keifman, Ettel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Riquelme, Luis Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Gmbh2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31779Belluscio, Mariano Andres; Escande, Mariela Veronica; Keifman, Ettel; Riquelme, Luis Alberto; Murer, Mario Gustavo; et al.; Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum; Elsevier Gmbh; Basal Ganglia; 3; 4; 4-2014; 203-2122210-5336CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S221053361300138Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.baga.2013.11.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:11:13Zoai:ri.conicet.gov.ar:11336/31779instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:11:13.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
title Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
spellingShingle Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
Belluscio, Mariano Andres
Parkinson'S Disease
Striatum
Oscillations
Synchronization
Globus Pallidus
Indirect Pathway
title_short Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
title_full Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
title_fullStr Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
title_full_unstemmed Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
title_sort Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
dc.creator.none.fl_str_mv Belluscio, Mariano Andres
Escande, Mariela Veronica
Keifman, Ettel
Riquelme, Luis Alberto
Murer, Mario Gustavo
Zold, Camila Lidia
author Belluscio, Mariano Andres
author_facet Belluscio, Mariano Andres
Escande, Mariela Veronica
Keifman, Ettel
Riquelme, Luis Alberto
Murer, Mario Gustavo
Zold, Camila Lidia
author_role author
author2 Escande, Mariela Veronica
Keifman, Ettel
Riquelme, Luis Alberto
Murer, Mario Gustavo
Zold, Camila Lidia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Parkinson'S Disease
Striatum
Oscillations
Synchronization
Globus Pallidus
Indirect Pathway
topic Parkinson'S Disease
Striatum
Oscillations
Synchronization
Globus Pallidus
Indirect Pathway
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In animal models of Parkinson´s disease cortical oscillations entrain abnormal synchronous rhythms in basal ganglia neurons. A mechanism accounting for these oscillations should: (i) vindicate a key role of the striatum in Parkinson´s disease pathophysiology by considering how alterations in striatal physiology may gate cortico-basal ganglia oscillations; (ii) explain why abnormal basal ganglia oscillations span the whole frequency range of oscillations observed in the normal frontal cortex; and (iii) provide insight into how these oscillations may relate to akinesia. Here we update our proposal that striatal projection neurons (medium spiny neurons) behave as dopamine-dependent filters which normally do not allow the propagation of resting cortical activity through the basal ganglia circuit. After chronic dopamine depletion, cortical oscillations would spread through more excitable medium spiny neurons to entrain the whole indirect pathway. Therefore, akinesia may not be directly related to oscillations, but to the inability of medium spiny neurons to separate salient pieces of cortical information from the ongoing cortical rhythms they are embedded in. We propose that uncontrolled translation of ongoing cortical activity into no-go signals in the indirect pathway induces akinesia. Thus, oscillations would be an extreme manifestation of this excessive permeability of medium spiny neurons to cortical input in advanced stages of Parkinson´s disease.
Fil: Belluscio, Mariano Andres. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Keifman, Ettel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Riquelme, Luis Alberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In animal models of Parkinson´s disease cortical oscillations entrain abnormal synchronous rhythms in basal ganglia neurons. A mechanism accounting for these oscillations should: (i) vindicate a key role of the striatum in Parkinson´s disease pathophysiology by considering how alterations in striatal physiology may gate cortico-basal ganglia oscillations; (ii) explain why abnormal basal ganglia oscillations span the whole frequency range of oscillations observed in the normal frontal cortex; and (iii) provide insight into how these oscillations may relate to akinesia. Here we update our proposal that striatal projection neurons (medium spiny neurons) behave as dopamine-dependent filters which normally do not allow the propagation of resting cortical activity through the basal ganglia circuit. After chronic dopamine depletion, cortical oscillations would spread through more excitable medium spiny neurons to entrain the whole indirect pathway. Therefore, akinesia may not be directly related to oscillations, but to the inability of medium spiny neurons to separate salient pieces of cortical information from the ongoing cortical rhythms they are embedded in. We propose that uncontrolled translation of ongoing cortical activity into no-go signals in the indirect pathway induces akinesia. Thus, oscillations would be an extreme manifestation of this excessive permeability of medium spiny neurons to cortical input in advanced stages of Parkinson´s disease.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31779
Belluscio, Mariano Andres; Escande, Mariela Veronica; Keifman, Ettel; Riquelme, Luis Alberto; Murer, Mario Gustavo; et al.; Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum; Elsevier Gmbh; Basal Ganglia; 3; 4; 4-2014; 203-212
2210-5336
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31779
identifier_str_mv Belluscio, Mariano Andres; Escande, Mariela Veronica; Keifman, Ettel; Riquelme, Luis Alberto; Murer, Mario Gustavo; et al.; Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum; Elsevier Gmbh; Basal Ganglia; 3; 4; 4-2014; 203-212
2210-5336
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S221053361300138X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.baga.2013.11.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh
publisher.none.fl_str_mv Elsevier Gmbh
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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