Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy

Autores
Hovsepian, Eugenia; Penas, Federico Nicolás; Mirkin, Gerardo Ariel Isidoro; Goren, Nora Beatriz
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in diverse tissues by triggering local expression of inflammatory mediators, which results in the upregulation of the levels of cytokines and chemokines, and important cardiac alterations in the host, being one of the most characteristic damages of Chagas disease. Therefore, controlling the inflammatory reaction becomes critical for the control of the proliferation of the parasite and of the evolution of Chagas disease. The nuclear receptors known as peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of lipid metabolism and inflammation. The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. This review summarizes our knowledge about T. cruzi infection as well as about the activation of PPARs and the potential role of their ligands in the resolution of inflammation, with the aim to address a new pharmacological approach to improve the host health.
Fil: Hovsepian, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Mirkin, Gerardo Ariel Isidoro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina
Fil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
TRYPANOSOMA CRUZI
PPAR
INFLAMMATION
HEART
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269578
Acceder
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spelling Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease TherapyHovsepian, EugeniaPenas, Federico NicolásMirkin, Gerardo Ariel IsidoroGoren, Nora BeatrizTRYPANOSOMA CRUZIPPARINFLAMMATIONHEARThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in diverse tissues by triggering local expression of inflammatory mediators, which results in the upregulation of the levels of cytokines and chemokines, and important cardiac alterations in the host, being one of the most characteristic damages of Chagas disease. Therefore, controlling the inflammatory reaction becomes critical for the control of the proliferation of the parasite and of the evolution of Chagas disease. The nuclear receptors known as peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of lipid metabolism and inflammation. The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. This review summarizes our knowledge about T. cruzi infection as well as about the activation of PPARs and the potential role of their ligands in the resolution of inflammation, with the aim to address a new pharmacological approach to improve the host health.Fil: Hovsepian, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Mirkin, Gerardo Ariel Isidoro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; ArgentinaFil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaHindawi Publishing Corporation2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269578Hovsepian, Eugenia; Penas, Federico Nicolás; Mirkin, Gerardo Ariel Isidoro; Goren, Nora Beatriz; Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy; Hindawi Publishing Corporation; PPAR Research; 2012; 2-2012; 1-81687-47571687-4765CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ppar/2012/528435/info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/528435info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:58Zoai:ri.conicet.gov.ar:11336/269578instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:59.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
title Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
spellingShingle Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
Hovsepian, Eugenia
TRYPANOSOMA CRUZI
PPAR
INFLAMMATION
HEART
title_short Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
title_full Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
title_fullStr Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
title_full_unstemmed Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
title_sort Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy
dc.creator.none.fl_str_mv Hovsepian, Eugenia
Penas, Federico Nicolás
Mirkin, Gerardo Ariel Isidoro
Goren, Nora Beatriz
author Hovsepian, Eugenia
author_facet Hovsepian, Eugenia
Penas, Federico Nicolás
Mirkin, Gerardo Ariel Isidoro
Goren, Nora Beatriz
author_role author
author2 Penas, Federico Nicolás
Mirkin, Gerardo Ariel Isidoro
Goren, Nora Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv TRYPANOSOMA CRUZI
PPAR
INFLAMMATION
HEART
topic TRYPANOSOMA CRUZI
PPAR
INFLAMMATION
HEART
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in diverse tissues by triggering local expression of inflammatory mediators, which results in the upregulation of the levels of cytokines and chemokines, and important cardiac alterations in the host, being one of the most characteristic damages of Chagas disease. Therefore, controlling the inflammatory reaction becomes critical for the control of the proliferation of the parasite and of the evolution of Chagas disease. The nuclear receptors known as peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of lipid metabolism and inflammation. The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. This review summarizes our knowledge about T. cruzi infection as well as about the activation of PPARs and the potential role of their ligands in the resolution of inflammation, with the aim to address a new pharmacological approach to improve the host health.
Fil: Hovsepian, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Mirkin, Gerardo Ariel Isidoro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Area Parasitología; Argentina
Fil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Chagas disease, which is caused by Trypanosoma cruzi (T. cruzi), remains a substantial public health concern and an important cause of morbidity and mortality in Latin America. T. cruzi infection causes an intense inflammatory response in diverse tissues by triggering local expression of inflammatory mediators, which results in the upregulation of the levels of cytokines and chemokines, and important cardiac alterations in the host, being one of the most characteristic damages of Chagas disease. Therefore, controlling the inflammatory reaction becomes critical for the control of the proliferation of the parasite and of the evolution of Chagas disease. The nuclear receptors known as peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of lipid metabolism and inflammation. The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. This review summarizes our knowledge about T. cruzi infection as well as about the activation of PPARs and the potential role of their ligands in the resolution of inflammation, with the aim to address a new pharmacological approach to improve the host health.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269578
Hovsepian, Eugenia; Penas, Federico Nicolás; Mirkin, Gerardo Ariel Isidoro; Goren, Nora Beatriz; Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy; Hindawi Publishing Corporation; PPAR Research; 2012; 2-2012; 1-8
1687-4757
1687-4765
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269578
identifier_str_mv Hovsepian, Eugenia; Penas, Federico Nicolás; Mirkin, Gerardo Ariel Isidoro; Goren, Nora Beatriz; Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy; Hindawi Publishing Corporation; PPAR Research; 2012; 2-2012; 1-8
1687-4757
1687-4765
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/ppar/2012/528435/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/528435
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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