New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide

Autores
Tartara, Luis Ignacio; Palma, Santiago Daniel; Ahumada, Maria I.; Allemandi, Daniel Alberto; Llabot, Juan Manuel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This article reports the results concerning the design and manufacture of a novel polymeric film for ocular ad-ministration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium car-boxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfac-tant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipita-tion of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cati-onic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (deter-mined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive properties of the swellable poly-mers. Thus, the system obtained, showed good efficiency and the intra ocular pressure (IOP) decreased according to the results derived from in vivo studies performed on normotensive rabbits. Finally, irritation scored studies demonstrated that these systems were not irritant for rabbit ́s ocular mucosa.
Fil: Tartara, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Ahumada, Maria I.. Universidad Nacional de Córdoba; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
A Cetazolamide
Glaucoma
Bioadhesive Films
Ophthalmic Delivery
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33458
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New Mucoadhesive Polymeric Film for Ophthalmic Administration of AcetazolamideTartara, Luis IgnacioPalma, Santiago DanielAhumada, Maria I.Allemandi, Daniel AlbertoLlabot, Juan ManuelA CetazolamideGlaucomaBioadhesive FilmsOphthalmic Deliveryhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This article reports the results concerning the design and manufacture of a novel polymeric film for ocular ad-ministration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium car-boxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfac-tant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipita-tion of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cati-onic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (deter-mined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive properties of the swellable poly-mers. Thus, the system obtained, showed good efficiency and the intra ocular pressure (IOP) decreased according to the results derived from in vivo studies performed on normotensive rabbits. Finally, irritation scored studies demonstrated that these systems were not irritant for rabbit ́s ocular mucosa.Fil: Tartara, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Ahumada, Maria I.. Universidad Nacional de Córdoba; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaBentham Science2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33458Ahumada, Maria I.; Tartara, Luis Ignacio; Palma, Santiago Daniel; Llabot, Juan Manuel; Allemandi, Daniel Alberto; New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide; Bentham Science; Recent Patents on Drug Delivery & Formulation; 8; 3; 8-2014; 224-2321872-21132212-4039CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1872211308666140908121632info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/124437/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:16:23Zoai:ri.conicet.gov.ar:11336/33458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:16:23.589CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
title New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
spellingShingle New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
Tartara, Luis Ignacio
A Cetazolamide
Glaucoma
Bioadhesive Films
Ophthalmic Delivery
title_short New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
title_full New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
title_fullStr New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
title_full_unstemmed New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
title_sort New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide
dc.creator.none.fl_str_mv Tartara, Luis Ignacio
Palma, Santiago Daniel
Ahumada, Maria I.
Allemandi, Daniel Alberto
Llabot, Juan Manuel
author Tartara, Luis Ignacio
author_facet Tartara, Luis Ignacio
Palma, Santiago Daniel
Ahumada, Maria I.
Allemandi, Daniel Alberto
Llabot, Juan Manuel
author_role author
author2 Palma, Santiago Daniel
Ahumada, Maria I.
Allemandi, Daniel Alberto
Llabot, Juan Manuel
author2_role author
author
author
author
dc.subject.none.fl_str_mv A Cetazolamide
Glaucoma
Bioadhesive Films
Ophthalmic Delivery
topic A Cetazolamide
Glaucoma
Bioadhesive Films
Ophthalmic Delivery
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This article reports the results concerning the design and manufacture of a novel polymeric film for ocular ad-ministration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium car-boxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfac-tant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipita-tion of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cati-onic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (deter-mined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive properties of the swellable poly-mers. Thus, the system obtained, showed good efficiency and the intra ocular pressure (IOP) decreased according to the results derived from in vivo studies performed on normotensive rabbits. Finally, irritation scored studies demonstrated that these systems were not irritant for rabbit ́s ocular mucosa.
Fil: Tartara, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Ahumada, Maria I.. Universidad Nacional de Córdoba; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Llabot, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description This article reports the results concerning the design and manufacture of a novel polymeric film for ocular ad-ministration of acetazolamide (AZM), and a patent document presented to INPI- National Institute of Industrial/Intelectual Property. The system was designed using mucoadhesive polymers, such as carbomer (CB974P) and sodium car-boxymethylcellulose (NaCMC), combined with the poloxamer (POL407) which behaves as a swelling modulator, surfac-tant and slightly plasticizer. The maximum amount of AZM to be incorporated without loss of homogeneity or precipita-tion of the drug, was 0.04 mg AZM/mg of the film. The addition of a polymeric coating based on Eudragit RSPO (cati-onic permeable polymethacrylate polymer) allowed optimizing drug release. The coating in a proportion of 10% (deter-mined as percentage of total weight of the film) seemed to be the most adequate, since 80% of controlled drug release was achieved along 240 minutes. This coating membrane did not affect the mucoadhesive properties of the swellable poly-mers. Thus, the system obtained, showed good efficiency and the intra ocular pressure (IOP) decreased according to the results derived from in vivo studies performed on normotensive rabbits. Finally, irritation scored studies demonstrated that these systems were not irritant for rabbit ́s ocular mucosa.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33458
Ahumada, Maria I.; Tartara, Luis Ignacio; Palma, Santiago Daniel; Llabot, Juan Manuel; Allemandi, Daniel Alberto; New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide; Bentham Science; Recent Patents on Drug Delivery & Formulation; 8; 3; 8-2014; 224-232
1872-2113
2212-4039
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33458
identifier_str_mv Ahumada, Maria I.; Tartara, Luis Ignacio; Palma, Santiago Daniel; Llabot, Juan Manuel; Allemandi, Daniel Alberto; New Mucoadhesive Polymeric Film for Ophthalmic Administration of Acetazolamide; Bentham Science; Recent Patents on Drug Delivery & Formulation; 8; 3; 8-2014; 224-232
1872-2113
2212-4039
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1872211308666140908121632
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/124437/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science
publisher.none.fl_str_mv Bentham Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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