Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach

Autores
Colmegna, Patricio Hernán; Bianchi, Fernando Daniel; Sanchez Peña, Ricardo Salvador
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this letter, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closed-loop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia.
Fil: Colmegna, Patricio Hernán. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bianchi, Fernando Daniel. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ARTIFICIAL PANCREAS
PHYSICAL ACTIVITY
SWITCHED LPV CONTROL
UNANNOUNCED MEALS
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155074
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV ApproachColmegna, Patricio HernánBianchi, Fernando DanielSanchez Peña, Ricardo SalvadorARTIFICIAL PANCREASPHYSICAL ACTIVITYSWITCHED LPV CONTROLUNANNOUNCED MEALShttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this letter, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closed-loop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia.Fil: Colmegna, Patricio Hernán. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bianchi, Fernando Daniel. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaInstitute of Electrical and Electronics Engineers2021-11info:eu-repo/date/embargoEnd/2022-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155074Colmegna, Patricio Hernán; Bianchi, Fernando Daniel; Sanchez Peña, Ricardo Salvador; Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach; Institute of Electrical and Electronics Engineers; IEEE Control Systems Letters; 5; 5; 11-2021; 1489-14942475-14562475-1456CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ieeexplore.ieee.org/document/9273055info:eu-repo/semantics/altIdentifier/doi/10.1109/LCSYS.2020.3041211info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:53Zoai:ri.conicet.gov.ar:11336/155074instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:53.653CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
title Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
spellingShingle Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
Colmegna, Patricio Hernán
ARTIFICIAL PANCREAS
PHYSICAL ACTIVITY
SWITCHED LPV CONTROL
UNANNOUNCED MEALS
title_short Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
title_full Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
title_fullStr Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
title_full_unstemmed Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
title_sort Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
dc.creator.none.fl_str_mv Colmegna, Patricio Hernán
Bianchi, Fernando Daniel
Sanchez Peña, Ricardo Salvador
author Colmegna, Patricio Hernán
author_facet Colmegna, Patricio Hernán
Bianchi, Fernando Daniel
Sanchez Peña, Ricardo Salvador
author_role author
author2 Bianchi, Fernando Daniel
Sanchez Peña, Ricardo Salvador
author2_role author
author
dc.subject.none.fl_str_mv ARTIFICIAL PANCREAS
PHYSICAL ACTIVITY
SWITCHED LPV CONTROL
UNANNOUNCED MEALS
topic ARTIFICIAL PANCREAS
PHYSICAL ACTIVITY
SWITCHED LPV CONTROL
UNANNOUNCED MEALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this letter, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closed-loop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia.
Fil: Colmegna, Patricio Hernán. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bianchi, Fernando Daniel. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this letter, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closed-loop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
info:eu-repo/date/embargoEnd/2022-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155074
Colmegna, Patricio Hernán; Bianchi, Fernando Daniel; Sanchez Peña, Ricardo Salvador; Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach; Institute of Electrical and Electronics Engineers; IEEE Control Systems Letters; 5; 5; 11-2021; 1489-1494
2475-1456
2475-1456
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155074
identifier_str_mv Colmegna, Patricio Hernán; Bianchi, Fernando Daniel; Sanchez Peña, Ricardo Salvador; Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach; Institute of Electrical and Electronics Engineers; IEEE Control Systems Letters; 5; 5; 11-2021; 1489-1494
2475-1456
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ieeexplore.ieee.org/document/9273055
info:eu-repo/semantics/altIdentifier/doi/10.1109/LCSYS.2020.3041211
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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