XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women

Autores
Barbisan, Gisela; Perez, Luis Orlando; Difranza, L; Fernandez, Cintia Judith; Ciancio, Noelia Esther; Golijow, Carlos Daniel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Difranza, L. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Fernandez, Cintia Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Ciancio, Noelia Esther. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Golijow, Carlos Daniel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
Cervical Cancer
Hpv
Single Nucleotide Polymorphism
Xrcc1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80944
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/80944
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine womenBarbisan, GiselaPerez, Luis OrlandoDifranza, LFernandez, Cintia JudithCiancio, Noelia EstherGolijow, Carlos DanielCervical CancerHpvSingle Nucleotide PolymorphismXrcc1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Difranza, L. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Fernandez, Cintia Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Ciancio, Noelia Esther. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Golijow, Carlos Daniel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaI R O G Canada, Inc2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80944Barbisan, Gisela; Perez, Luis Orlando; Difranza, L; Fernandez, Cintia Judith; Ciancio, Noelia Esther; et al.; XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women; I R O G Canada, Inc; European Journal Of Gynaecological Oncology; 32; 3; 3-2011; 274-2790392-2936CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.irog.net/ejgoinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:37:59Zoai:ri.conicet.gov.ar:11336/80944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:37:59.719CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
title XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
spellingShingle XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
Barbisan, Gisela
Cervical Cancer
Hpv
Single Nucleotide Polymorphism
Xrcc1
title_short XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
title_full XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
title_fullStr XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
title_full_unstemmed XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
title_sort XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
dc.creator.none.fl_str_mv Barbisan, Gisela
Perez, Luis Orlando
Difranza, L
Fernandez, Cintia Judith
Ciancio, Noelia Esther
Golijow, Carlos Daniel
author Barbisan, Gisela
author_facet Barbisan, Gisela
Perez, Luis Orlando
Difranza, L
Fernandez, Cintia Judith
Ciancio, Noelia Esther
Golijow, Carlos Daniel
author_role author
author2 Perez, Luis Orlando
Difranza, L
Fernandez, Cintia Judith
Ciancio, Noelia Esther
Golijow, Carlos Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cervical Cancer
Hpv
Single Nucleotide Polymorphism
Xrcc1
topic Cervical Cancer
Hpv
Single Nucleotide Polymorphism
Xrcc1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Difranza, L. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Fernandez, Cintia Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Ciancio, Noelia Esther. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Golijow, Carlos Daniel. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description Background: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the base excesion repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. Materia and Methods: we conducted a case control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. Results: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associatted with a decreased risk for cervical carcinoma. Conclusions: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80944
Barbisan, Gisela; Perez, Luis Orlando; Difranza, L; Fernandez, Cintia Judith; Ciancio, Noelia Esther; et al.; XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women; I R O G Canada, Inc; European Journal Of Gynaecological Oncology; 32; 3; 3-2011; 274-279
0392-2936
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80944
identifier_str_mv Barbisan, Gisela; Perez, Luis Orlando; Difranza, L; Fernandez, Cintia Judith; Ciancio, Noelia Esther; et al.; XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women; I R O G Canada, Inc; European Journal Of Gynaecological Oncology; 32; 3; 3-2011; 274-279
0392-2936
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.irog.net/ejgo
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv I R O G Canada, Inc
publisher.none.fl_str_mv I R O G Canada, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.121305

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