Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp

Autores
Fallati, Claudia Silvina; Olivera, Maria Eugenia; Luciani Giacobbe, Laura Carolina; Romañuk, Carolina Beatriz; Manzo, Ruben Hilario
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urinary infections. Five volunteers received a daily oral intake of Aloe saponaria pulp for 7 days. Urine samples were collected at time 0 and on the seventh day and assayed for their mannose contents by Dubois method, TLC, HPLC and 1H-NMR. The results showed that the oral intake of Aloe Saponaria fresh pulp produced sugar excretion, composed mainly of mannose and mannose related compounds, suggesting that Aloe saponaria pulp could be a potential therapeutic agent for prevention of urinary tract infection.
Fil: Fallati, Claudia Silvina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Olivera, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Luciani Giacobbe, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Romañuk, Carolina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Aloe Saponaria
Mannose
Urinary Excretion
Urinary Tract Infection
Anti-Adhesion Therapy
Uropathogenic Escherichia Coli
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24098
Acceder
id CONICETDig_7f4e5a6e5d6768c1788e51d4cdcee7eb
oai_identifier_str oai:ri.conicet.gov.ar:11336/24098
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulpFallati, Claudia SilvinaOlivera, Maria EugeniaLuciani Giacobbe, Laura CarolinaRomañuk, Carolina BeatrizManzo, Ruben HilarioAloe SaponariaMannoseUrinary ExcretionUrinary Tract InfectionAnti-Adhesion TherapyUropathogenic Escherichia Colihttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urinary infections. Five volunteers received a daily oral intake of Aloe saponaria pulp for 7 days. Urine samples were collected at time 0 and on the seventh day and assayed for their mannose contents by Dubois method, TLC, HPLC and 1H-NMR. The results showed that the oral intake of Aloe Saponaria fresh pulp produced sugar excretion, composed mainly of mannose and mannose related compounds, suggesting that Aloe saponaria pulp could be a potential therapeutic agent for prevention of urinary tract infection.Fil: Fallati, Claudia Silvina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Olivera, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Luciani Giacobbe, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Romañuk, Carolina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaInternational Scholars Journals2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24098Fallati, Claudia Silvina; Olivera, Maria Eugenia; Luciani Giacobbe, Laura Carolina; Romañuk, Carolina Beatriz; Manzo, Ruben Hilario; Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp; International Scholars Journals; International Journal of Pharmacy and Pharmacology; 2; 5; 8-2013; 88-932326-7267CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://internationalscholarsjournals.org/journal/ijpp/articles/urinary-excretion-of-mannose-and-mannose-related-compounds-in-humans-consuming-aloe-saponaria-pulpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:17Zoai:ri.conicet.gov.ar:11336/24098instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:18.161CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
title Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
spellingShingle Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
Fallati, Claudia Silvina
Aloe Saponaria
Mannose
Urinary Excretion
Urinary Tract Infection
Anti-Adhesion Therapy
Uropathogenic Escherichia Coli
title_short Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
title_full Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
title_fullStr Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
title_full_unstemmed Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
title_sort Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp
dc.creator.none.fl_str_mv Fallati, Claudia Silvina
Olivera, Maria Eugenia
Luciani Giacobbe, Laura Carolina
Romañuk, Carolina Beatriz
Manzo, Ruben Hilario
author Fallati, Claudia Silvina
author_facet Fallati, Claudia Silvina
Olivera, Maria Eugenia
Luciani Giacobbe, Laura Carolina
Romañuk, Carolina Beatriz
Manzo, Ruben Hilario
author_role author
author2 Olivera, Maria Eugenia
Luciani Giacobbe, Laura Carolina
Romañuk, Carolina Beatriz
Manzo, Ruben Hilario
author2_role author
author
author
author
dc.subject.none.fl_str_mv Aloe Saponaria
Mannose
Urinary Excretion
Urinary Tract Infection
Anti-Adhesion Therapy
Uropathogenic Escherichia Coli
topic Aloe Saponaria
Mannose
Urinary Excretion
Urinary Tract Infection
Anti-Adhesion Therapy
Uropathogenic Escherichia Coli
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urinary infections. Five volunteers received a daily oral intake of Aloe saponaria pulp for 7 days. Urine samples were collected at time 0 and on the seventh day and assayed for their mannose contents by Dubois method, TLC, HPLC and 1H-NMR. The results showed that the oral intake of Aloe Saponaria fresh pulp produced sugar excretion, composed mainly of mannose and mannose related compounds, suggesting that Aloe saponaria pulp could be a potential therapeutic agent for prevention of urinary tract infection.
Fil: Fallati, Claudia Silvina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Olivera, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Luciani Giacobbe, Laura Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Romañuk, Carolina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description The adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urinary infections. Five volunteers received a daily oral intake of Aloe saponaria pulp for 7 days. Urine samples were collected at time 0 and on the seventh day and assayed for their mannose contents by Dubois method, TLC, HPLC and 1H-NMR. The results showed that the oral intake of Aloe Saponaria fresh pulp produced sugar excretion, composed mainly of mannose and mannose related compounds, suggesting that Aloe saponaria pulp could be a potential therapeutic agent for prevention of urinary tract infection.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24098
Fallati, Claudia Silvina; Olivera, Maria Eugenia; Luciani Giacobbe, Laura Carolina; Romañuk, Carolina Beatriz; Manzo, Ruben Hilario; Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp; International Scholars Journals; International Journal of Pharmacy and Pharmacology; 2; 5; 8-2013; 88-93
2326-7267
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24098
identifier_str_mv Fallati, Claudia Silvina; Olivera, Maria Eugenia; Luciani Giacobbe, Laura Carolina; Romañuk, Carolina Beatriz; Manzo, Ruben Hilario; Urinary excretion of mannose and mannose related compounds in humans consuming Aloe saponaria pulp; International Scholars Journals; International Journal of Pharmacy and Pharmacology; 2; 5; 8-2013; 88-93
2326-7267
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://internationalscholarsjournals.org/journal/ijpp/articles/urinary-excretion-of-mannose-and-mannose-related-compounds-in-humans-consuming-aloe-saponaria-pulp
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Scholars Journals
publisher.none.fl_str_mv International Scholars Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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