Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols

Autores
Perez Mitta, Gonzalo; Burr, Loïc; Tunineti, Jimena S.; Trautmann, Christina; Toimil- Molares, María Eugenia; Azzaroni, Omar
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric-amphipathic polymers, also known as "amphipols", into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.
Fil: Perez Mitta, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Burr, Loïc. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; Alemania
Fil: Tunineti, Jimena S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Trautmann, Christina. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; Alemania
Fil: Toimil- Molares, María Eugenia. GSI Helmholtzzentrum für Schwerionenforschung; Alemania
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Materia
Solid-State Nanopores
Noncovalent Functionalization
Nanofluidic Devices
Lonic Rectifiers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81565
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/81565
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Noncovalent functionalization of solid-state nanopores via self-assembly of amphipolsPerez Mitta, GonzaloBurr, LoïcTunineti, Jimena S.Trautmann, ChristinaToimil- Molares, María EugeniaAzzaroni, OmarSolid-State NanoporesNoncovalent FunctionalizationNanofluidic DevicesLonic Rectifiershttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric-amphipathic polymers, also known as "amphipols", into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.Fil: Perez Mitta, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Burr, Loïc. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; AlemaniaFil: Tunineti, Jimena S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Trautmann, Christina. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; AlemaniaFil: Toimil- Molares, María Eugenia. GSI Helmholtzzentrum für Schwerionenforschung; AlemaniaFil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaRoyal Society of Chemistry2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81565Perez Mitta, Gonzalo; Burr, Loïc; Tunineti, Jimena S.; Trautmann, Christina; Toimil- Molares, María Eugenia; et al.; Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols; Royal Society of Chemistry; Nanoscale; 8; 3; 1-2016; 1470-14782040-3372CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c5nr08190dinfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2016/NR/C5NR08190Dinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:37Zoai:ri.conicet.gov.ar:11336/81565instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:37.655CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
title Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
spellingShingle Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
Perez Mitta, Gonzalo
Solid-State Nanopores
Noncovalent Functionalization
Nanofluidic Devices
Lonic Rectifiers
title_short Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
title_full Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
title_fullStr Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
title_full_unstemmed Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
title_sort Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
dc.creator.none.fl_str_mv Perez Mitta, Gonzalo
Burr, Loïc
Tunineti, Jimena S.
Trautmann, Christina
Toimil- Molares, María Eugenia
Azzaroni, Omar
author Perez Mitta, Gonzalo
author_facet Perez Mitta, Gonzalo
Burr, Loïc
Tunineti, Jimena S.
Trautmann, Christina
Toimil- Molares, María Eugenia
Azzaroni, Omar
author_role author
author2 Burr, Loïc
Tunineti, Jimena S.
Trautmann, Christina
Toimil- Molares, María Eugenia
Azzaroni, Omar
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Solid-State Nanopores
Noncovalent Functionalization
Nanofluidic Devices
Lonic Rectifiers
topic Solid-State Nanopores
Noncovalent Functionalization
Nanofluidic Devices
Lonic Rectifiers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric-amphipathic polymers, also known as "amphipols", into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.
Fil: Perez Mitta, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Burr, Loïc. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; Alemania
Fil: Tunineti, Jimena S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Trautmann, Christina. GSI Helmholtzzentrum für Schwerionenforschung; Alemania. Technische Universität Darmstadt. Materialwissenschaft; Alemania
Fil: Toimil- Molares, María Eugenia. GSI Helmholtzzentrum für Schwerionenforschung; Alemania
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
description In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric-amphipathic polymers, also known as "amphipols", into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81565
Perez Mitta, Gonzalo; Burr, Loïc; Tunineti, Jimena S.; Trautmann, Christina; Toimil- Molares, María Eugenia; et al.; Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols; Royal Society of Chemistry; Nanoscale; 8; 3; 1-2016; 1470-1478
2040-3372
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81565
identifier_str_mv Perez Mitta, Gonzalo; Burr, Loïc; Tunineti, Jimena S.; Trautmann, Christina; Toimil- Molares, María Eugenia; et al.; Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols; Royal Society of Chemistry; Nanoscale; 8; 3; 1-2016; 1470-1478
2040-3372
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c5nr08190d
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2016/NR/C5NR08190D
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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