Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients

Autores
Rojas, Juan Ignacio; Murphy, Georgina; Sánchez, Francisco; Patrucco, Liliana; Fernandez, Maria C.; Miguez, Jimena; Funes, Jorge; Golimstok, Angel; Cristiano, Edgardo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods: A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results: Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion: We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment.
Fil: Rojas, Juan Ignacio. Hospital Italiano; Argentina
Fil: Murphy, Georgina. Hospital Italiano; Argentina
Fil: Sánchez, Francisco. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Patrucco, Liliana. Hospital Italiano; Argentina
Fil: Fernandez, Maria C.. Hospital Italiano; Argentina
Fil: Miguez, Jimena. Hospital Italiano; Argentina
Fil: Funes, Jorge. Hospital Italiano; Argentina
Fil: Golimstok, Angel. Hospital Italiano; Argentina
Fil: Cristiano, Edgardo. Hospital Italiano; Argentina
Materia
BRAIN VOLUME
COGNITIVE IMPAIRMENT
MULTIPLE SCLEROSIS
THALAMUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87285
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/87285
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patientsRojas, Juan IgnacioMurphy, GeorginaSánchez, FranciscoPatrucco, LilianaFernandez, Maria C.Miguez, JimenaFunes, JorgeGolimstok, AngelCristiano, EdgardoBRAIN VOLUMECOGNITIVE IMPAIRMENTMULTIPLE SCLEROSISTHALAMUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aims: The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods: A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results: Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion: We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment.Fil: Rojas, Juan Ignacio. Hospital Italiano; ArgentinaFil: Murphy, Georgina. Hospital Italiano; ArgentinaFil: Sánchez, Francisco. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Patrucco, Liliana. Hospital Italiano; ArgentinaFil: Fernandez, Maria C.. Hospital Italiano; ArgentinaFil: Miguez, Jimena. Hospital Italiano; ArgentinaFil: Funes, Jorge. Hospital Italiano; ArgentinaFil: Golimstok, Angel. Hospital Italiano; ArgentinaFil: Cristiano, Edgardo. Hospital Italiano; ArgentinaSAGE Publications2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87285Rojas, Juan Ignacio; Murphy, Georgina; Sánchez, Francisco; Patrucco, Liliana; Fernandez, Maria C.; et al.; Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients; SAGE Publications; Neuroradiology Journal; 31; 4; 6-2018; 350-3551971-4009CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1971400918781977info:eu-repo/semantics/altIdentifier/doi/10.1177/1971400918781977info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:41:04Zoai:ri.conicet.gov.ar:11336/87285instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:41:04.301CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
title Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
spellingShingle Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
Rojas, Juan Ignacio
BRAIN VOLUME
COGNITIVE IMPAIRMENT
MULTIPLE SCLEROSIS
THALAMUS
title_short Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
title_full Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
title_fullStr Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
title_full_unstemmed Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
title_sort Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients
dc.creator.none.fl_str_mv Rojas, Juan Ignacio
Murphy, Georgina
Sánchez, Francisco
Patrucco, Liliana
Fernandez, Maria C.
Miguez, Jimena
Funes, Jorge
Golimstok, Angel
Cristiano, Edgardo
author Rojas, Juan Ignacio
author_facet Rojas, Juan Ignacio
Murphy, Georgina
Sánchez, Francisco
Patrucco, Liliana
Fernandez, Maria C.
Miguez, Jimena
Funes, Jorge
Golimstok, Angel
Cristiano, Edgardo
author_role author
author2 Murphy, Georgina
Sánchez, Francisco
Patrucco, Liliana
Fernandez, Maria C.
Miguez, Jimena
Funes, Jorge
Golimstok, Angel
Cristiano, Edgardo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN VOLUME
COGNITIVE IMPAIRMENT
MULTIPLE SCLEROSIS
THALAMUS
topic BRAIN VOLUME
COGNITIVE IMPAIRMENT
MULTIPLE SCLEROSIS
THALAMUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods: A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results: Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion: We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment.
Fil: Rojas, Juan Ignacio. Hospital Italiano; Argentina
Fil: Murphy, Georgina. Hospital Italiano; Argentina
Fil: Sánchez, Francisco. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Patrucco, Liliana. Hospital Italiano; Argentina
Fil: Fernandez, Maria C.. Hospital Italiano; Argentina
Fil: Miguez, Jimena. Hospital Italiano; Argentina
Fil: Funes, Jorge. Hospital Italiano; Argentina
Fil: Golimstok, Angel. Hospital Italiano; Argentina
Fil: Cristiano, Edgardo. Hospital Italiano; Argentina
description Aims: The objective of the study was to assess whether changes in the volume of the thalamus during the onset of multiple sclerosis predict cognitive impairment after accounting for the effects of brain volume loss. Methods: A prospective study included patients with relapsing–remitting multiple sclerosis less than 3 years after disease onset (defined as the first demyelinating symptom), Expanded Disability Status Scale of 3 or less, no history of cognitive impairment and at least 2 years of follow-up. Patients were clinically followed up with annual brain magnetic resonance imaging and neuropsychological evaluations for 2 years. Measures of memory, information processing speed and executive function were evaluated at baseline and follow-up with a comprehensive neuropsychological test battery. After 2 years, the patients were classified into two groups, one with and the other without cognitive impairment. Brain dual-echo, high-resolution three-dimensional T1-weighted magnetic resonance imaging scans were acquired at baseline and every 12 months for 2 years. Between-group differences in thalamus volume, total and neocortical grey matter and white matter volumes were assessed using FIRST, SIENA, SIENAXr, FIRST software (logistic regression analysis P < 0.05 significant). Results: Sixty-one patients, mean age 38.4 years, 35 (57%) women were included. At 2 years of follow-up, 17 (28%) had cognitive impairment. Cognitive impairment patients exhibited significantly slower information processing speed and attentional deficits compared with patients without cognitive impairment (P < 0.001 and P = 0.02, respectively). In the cognitive impairment group a significant reduction in the percentage of thalamus volume (P < 0.001) was observed compared with the group without cognitive impairment. Conclusion: We observed a significant decrease in thalamus volume in multiple sclerosis-related cognitive impairment.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87285
Rojas, Juan Ignacio; Murphy, Georgina; Sánchez, Francisco; Patrucco, Liliana; Fernandez, Maria C.; et al.; Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients; SAGE Publications; Neuroradiology Journal; 31; 4; 6-2018; 350-355
1971-4009
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87285
identifier_str_mv Rojas, Juan Ignacio; Murphy, Georgina; Sánchez, Francisco; Patrucco, Liliana; Fernandez, Maria C.; et al.; Thalamus volume change and cognitive impairment in early relapsing–remitting multiple sclerosis patients; SAGE Publications; Neuroradiology Journal; 31; 4; 6-2018; 350-355
1971-4009
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1971400918781977
info:eu-repo/semantics/altIdentifier/doi/10.1177/1971400918781977
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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