A kinetic model for horizontal transfer and bacterial antibiotic resistance

Autores
Knopoff, Damián Alejandro; Sánchez Sansó, Juan M.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics.
Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Sánchez Sansó, Juan M.. Hospital Misericordia Nuevo Siglo; Argentina
Materia
Active Particles
Antibiotic Resistance
Horizontal Gene Transfer
Kinetic Theory
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59980
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/59980
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A kinetic model for horizontal transfer and bacterial antibiotic resistanceKnopoff, Damián AlejandroSánchez Sansó, Juan M.Active ParticlesAntibiotic ResistanceHorizontal Gene TransferKinetic Theoryhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics.Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; ArgentinaFil: Sánchez Sansó, Juan M.. Hospital Misericordia Nuevo Siglo; ArgentinaWorld Scientific2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59980Knopoff, Damián Alejandro; Sánchez Sansó, Juan M.; A kinetic model for horizontal transfer and bacterial antibiotic resistance; World Scientific; International Journal of Biomathematics; 10; 4; 5-2017; 1-21; 17500511793-52451793-7159CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1142/S1793524517500516info:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1793524517500516info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:29Zoai:ri.conicet.gov.ar:11336/59980instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:30.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A kinetic model for horizontal transfer and bacterial antibiotic resistance
title A kinetic model for horizontal transfer and bacterial antibiotic resistance
spellingShingle A kinetic model for horizontal transfer and bacterial antibiotic resistance
Knopoff, Damián Alejandro
Active Particles
Antibiotic Resistance
Horizontal Gene Transfer
Kinetic Theory
title_short A kinetic model for horizontal transfer and bacterial antibiotic resistance
title_full A kinetic model for horizontal transfer and bacterial antibiotic resistance
title_fullStr A kinetic model for horizontal transfer and bacterial antibiotic resistance
title_full_unstemmed A kinetic model for horizontal transfer and bacterial antibiotic resistance
title_sort A kinetic model for horizontal transfer and bacterial antibiotic resistance
dc.creator.none.fl_str_mv Knopoff, Damián Alejandro
Sánchez Sansó, Juan M.
author Knopoff, Damián Alejandro
author_facet Knopoff, Damián Alejandro
Sánchez Sansó, Juan M.
author_role author
author2 Sánchez Sansó, Juan M.
author2_role author
dc.subject.none.fl_str_mv Active Particles
Antibiotic Resistance
Horizontal Gene Transfer
Kinetic Theory
topic Active Particles
Antibiotic Resistance
Horizontal Gene Transfer
Kinetic Theory
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics.
Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Sánchez Sansó, Juan M.. Hospital Misericordia Nuevo Siglo; Argentina
description This paper presents a mathematical model for bacterial growth, mutations, horizontal transfer and development of antibiotic resistance. The model is based on the so-called kinetic theory for active particles that is able to capture the main complexity features of the system. Bacterial and immune cells are viewed as active particles whose microscopic state is described by a scalar variable. Particles interact among them and the temporal evolution of the system is described by a generalized distribution function over the microscopic state. The model is derived and tested in a couple of case studies in order to confirm its ability to describe one of the most fundamental problems of modern medicine, namely bacterial resistance to antibiotics.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59980
Knopoff, Damián Alejandro; Sánchez Sansó, Juan M.; A kinetic model for horizontal transfer and bacterial antibiotic resistance; World Scientific; International Journal of Biomathematics; 10; 4; 5-2017; 1-21; 1750051
1793-5245
1793-7159
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59980
identifier_str_mv Knopoff, Damián Alejandro; Sánchez Sansó, Juan M.; A kinetic model for horizontal transfer and bacterial antibiotic resistance; World Scientific; International Journal of Biomathematics; 10; 4; 5-2017; 1-21; 1750051
1793-5245
1793-7159
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1142/S1793524517500516
info:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S1793524517500516
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Scientific
publisher.none.fl_str_mv World Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268976610017280
score 13.13397

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