Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation

Autores
Bianco, German Ariel; Toscano, Marta Alicia; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Protein-glycan interactions control essential immunological processes, including T-cell activation, differentiation and survival. Galectins, carbohydrate-binding proteins, defined by shared consensus amino acid sequences and affinity for beta-galactose-containing oligosaccharides, participate in a wide spectrum of immunological processes. These carbohydrate-binding proteins regulate the development of pathogenic T-cell responses by influencing T-cell survival, activation and cytokine secretion. Administration of recombinant galectins or their genetic delivery modulate the development and severity of chronic inflammatory responses in experimental models of autoimmunity by triggering different and potentially overlapping immunoregulatory mechanisms. Given the potential use of galectins as novel anti-inflammatory agents or targets for immunosuppressive drugs, we will summarize here recent findings on the influence of these carbohydrate-binding proteins in autoimmune and chronic inflammatory disorders.
Fil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Toscano, Marta Alicia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ilarregui, Juan Martin. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Apoptosis
Autoimmunity
Galectins
Glycosylation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28808
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammationBianco, German ArielToscano, Marta AliciaIlarregui, Juan MartinRabinovich, Gabriel AdriánApoptosisAutoimmunityGalectinsGlycosylationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Protein-glycan interactions control essential immunological processes, including T-cell activation, differentiation and survival. Galectins, carbohydrate-binding proteins, defined by shared consensus amino acid sequences and affinity for beta-galactose-containing oligosaccharides, participate in a wide spectrum of immunological processes. These carbohydrate-binding proteins regulate the development of pathogenic T-cell responses by influencing T-cell survival, activation and cytokine secretion. Administration of recombinant galectins or their genetic delivery modulate the development and severity of chronic inflammatory responses in experimental models of autoimmunity by triggering different and potentially overlapping immunoregulatory mechanisms. Given the potential use of galectins as novel anti-inflammatory agents or targets for immunosuppressive drugs, we will summarize here recent findings on the influence of these carbohydrate-binding proteins in autoimmune and chronic inflammatory disorders.Fil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Toscano, Marta Alicia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ilarregui, Juan Martin. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaElsevier Science2006-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28808Bianco, German Ariel; Toscano, Marta Alicia; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián; Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation; Elsevier Science; Autoimmunity Reviews; 5; 5; 5-2006; 349-3561568-99721873-0183CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S156899720600022X?via%3Dihub#!info:eu-repo/semantics/altIdentifier/doi/10.1016/j.autrev.2006.02.003info:eu-repo/semantics/altIdentifier/pmid/16782561info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:29Zoai:ri.conicet.gov.ar:11336/28808instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:29.622CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
title Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
spellingShingle Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
Bianco, German Ariel
Apoptosis
Autoimmunity
Galectins
Glycosylation
title_short Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
title_full Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
title_fullStr Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
title_full_unstemmed Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
title_sort Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation
dc.creator.none.fl_str_mv Bianco, German Ariel
Toscano, Marta Alicia
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author Bianco, German Ariel
author_facet Bianco, German Ariel
Toscano, Marta Alicia
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author_role author
author2 Toscano, Marta Alicia
Ilarregui, Juan Martin
Rabinovich, Gabriel Adrián
author2_role author
author
author
dc.subject.none.fl_str_mv Apoptosis
Autoimmunity
Galectins
Glycosylation
topic Apoptosis
Autoimmunity
Galectins
Glycosylation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Protein-glycan interactions control essential immunological processes, including T-cell activation, differentiation and survival. Galectins, carbohydrate-binding proteins, defined by shared consensus amino acid sequences and affinity for beta-galactose-containing oligosaccharides, participate in a wide spectrum of immunological processes. These carbohydrate-binding proteins regulate the development of pathogenic T-cell responses by influencing T-cell survival, activation and cytokine secretion. Administration of recombinant galectins or their genetic delivery modulate the development and severity of chronic inflammatory responses in experimental models of autoimmunity by triggering different and potentially overlapping immunoregulatory mechanisms. Given the potential use of galectins as novel anti-inflammatory agents or targets for immunosuppressive drugs, we will summarize here recent findings on the influence of these carbohydrate-binding proteins in autoimmune and chronic inflammatory disorders.
Fil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Toscano, Marta Alicia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ilarregui, Juan Martin. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Protein-glycan interactions control essential immunological processes, including T-cell activation, differentiation and survival. Galectins, carbohydrate-binding proteins, defined by shared consensus amino acid sequences and affinity for beta-galactose-containing oligosaccharides, participate in a wide spectrum of immunological processes. These carbohydrate-binding proteins regulate the development of pathogenic T-cell responses by influencing T-cell survival, activation and cytokine secretion. Administration of recombinant galectins or their genetic delivery modulate the development and severity of chronic inflammatory responses in experimental models of autoimmunity by triggering different and potentially overlapping immunoregulatory mechanisms. Given the potential use of galectins as novel anti-inflammatory agents or targets for immunosuppressive drugs, we will summarize here recent findings on the influence of these carbohydrate-binding proteins in autoimmune and chronic inflammatory disorders.
publishDate 2006
dc.date.none.fl_str_mv 2006-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28808
Bianco, German Ariel; Toscano, Marta Alicia; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián; Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation; Elsevier Science; Autoimmunity Reviews; 5; 5; 5-2006; 349-356
1568-9972
1873-0183
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28808
identifier_str_mv Bianco, German Ariel; Toscano, Marta Alicia; Ilarregui, Juan Martin; Rabinovich, Gabriel Adrián; Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation; Elsevier Science; Autoimmunity Reviews; 5; 5; 5-2006; 349-356
1568-9972
1873-0183
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S156899720600022X?via%3Dihub#!
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.autrev.2006.02.003
info:eu-repo/semantics/altIdentifier/pmid/16782561
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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