Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice

Autores
Delgado Morales, Raúl; del Río, Eva; Gómez Román, Almudena; Bisagno, Veronica; Nadal, Roser; de Felipe, Carmen; Armario, Antonio
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brain substance P and its receptor (neurokinin-1, NK1) have a widespread brain distribution and are involved in an important number of behavioural and physiological responses to emotional stimuli. However, the role of NK1 receptors in the consequences of exposure to chronic stress has not been explored. The present study focused on the role of these receptors in the hypothalamic-pituitary-adrenal (HPA) response to daily repeated restraint stress (evaluated by plasma corticosterone levels), as well as on the effect of this procedure on anxiety-like behaviour, spatial learning and memory in the Morris water maze (MWM), a hippocampus-dependent task. Adult null mutant NK1-/- mice, with a C57BL/6J background, and the corresponding wild-type mice showed similar resting corticosterone levels and, also, did not differ in corticosterone response to a first restraint. Nevertheless, adaptation to the repeated stressor was faster in NK1-/- mice. Chronic restraint modestly increased anxiety-like behaviour in the light-dark test, irrespective of genotype. Throughout the days of the MWM trials, NK1-/- mice showed a similar learning rate to that of wild-type mice, but had lower levels of thigmotaxis and showed a better retention in the probe trial. Chronic restraint stress did not affect these variables in either genotype. These results indicate that deletion of the NK1 receptor does not alter behavioural susceptibility to chronic repeated stress in mice, but accelerates adaptation of the HPA axis. In addition, deletion may result in lower levels of thigmotaxis and improved short-term spatial memory, perhaps reflecting a better learning strategy in the MWM. © 2011 Elsevier Inc.
Fil: Delgado Morales, Raúl. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: del Río, Eva. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Gómez Román, Almudena. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Nadal, Roser. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: de Felipe, Carmen. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Armario, Antonio. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Materia
Adaptation
Anxiety
Chronic Stress
Corticosterone
Nk1-/- Mice
Spatial Learning
Substance P
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67548
Acceder
id CONICETDig_d820c71004247c95ea66f33cbfe67183
oai_identifier_str oai:ri.conicet.gov.ar:11336/67548
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout miceDelgado Morales, Raúldel Río, EvaGómez Román, AlmudenaBisagno, VeronicaNadal, Roserde Felipe, CarmenArmario, AntonioAdaptationAnxietyChronic StressCorticosteroneNk1-/- MiceSpatial LearningSubstance Phttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Brain substance P and its receptor (neurokinin-1, NK1) have a widespread brain distribution and are involved in an important number of behavioural and physiological responses to emotional stimuli. However, the role of NK1 receptors in the consequences of exposure to chronic stress has not been explored. The present study focused on the role of these receptors in the hypothalamic-pituitary-adrenal (HPA) response to daily repeated restraint stress (evaluated by plasma corticosterone levels), as well as on the effect of this procedure on anxiety-like behaviour, spatial learning and memory in the Morris water maze (MWM), a hippocampus-dependent task. Adult null mutant NK1-/- mice, with a C57BL/6J background, and the corresponding wild-type mice showed similar resting corticosterone levels and, also, did not differ in corticosterone response to a first restraint. Nevertheless, adaptation to the repeated stressor was faster in NK1-/- mice. Chronic restraint modestly increased anxiety-like behaviour in the light-dark test, irrespective of genotype. Throughout the days of the MWM trials, NK1-/- mice showed a similar learning rate to that of wild-type mice, but had lower levels of thigmotaxis and showed a better retention in the probe trial. Chronic restraint stress did not affect these variables in either genotype. These results indicate that deletion of the NK1 receptor does not alter behavioural susceptibility to chronic repeated stress in mice, but accelerates adaptation of the HPA axis. In addition, deletion may result in lower levels of thigmotaxis and improved short-term spatial memory, perhaps reflecting a better learning strategy in the MWM. © 2011 Elsevier Inc.Fil: Delgado Morales, Raúl. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; EspañaFil: del Río, Eva. Red de trastornos adictivos; España. Universidad Miguel Hernández; EspañaFil: Gómez Román, Almudena. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; EspañaFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Red de trastornos adictivos; España. Universidad Miguel Hernández; EspañaFil: Nadal, Roser. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; EspañaFil: de Felipe, Carmen. Red de trastornos adictivos; España. Universidad Miguel Hernández; EspañaFil: Armario, Antonio. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; EspañaPergamon-Elsevier Science Ltd2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67548Delgado Morales, Raúl; del Río, Eva; Gómez Román, Almudena; Bisagno, Veronica; Nadal, Roser; et al.; Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 105; 3; 2-2012; 669-6750031-9384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2011.10.008info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031938411004859info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:37:08Zoai:ri.conicet.gov.ar:11336/67548instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:37:08.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
title Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
spellingShingle Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
Delgado Morales, Raúl
Adaptation
Anxiety
Chronic Stress
Corticosterone
Nk1-/- Mice
Spatial Learning
Substance P
title_short Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
title_full Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
title_fullStr Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
title_full_unstemmed Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
title_sort Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice
dc.creator.none.fl_str_mv Delgado Morales, Raúl
del Río, Eva
Gómez Román, Almudena
Bisagno, Veronica
Nadal, Roser
de Felipe, Carmen
Armario, Antonio
author Delgado Morales, Raúl
author_facet Delgado Morales, Raúl
del Río, Eva
Gómez Román, Almudena
Bisagno, Veronica
Nadal, Roser
de Felipe, Carmen
Armario, Antonio
author_role author
author2 del Río, Eva
Gómez Román, Almudena
Bisagno, Veronica
Nadal, Roser
de Felipe, Carmen
Armario, Antonio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Adaptation
Anxiety
Chronic Stress
Corticosterone
Nk1-/- Mice
Spatial Learning
Substance P
topic Adaptation
Anxiety
Chronic Stress
Corticosterone
Nk1-/- Mice
Spatial Learning
Substance P
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Brain substance P and its receptor (neurokinin-1, NK1) have a widespread brain distribution and are involved in an important number of behavioural and physiological responses to emotional stimuli. However, the role of NK1 receptors in the consequences of exposure to chronic stress has not been explored. The present study focused on the role of these receptors in the hypothalamic-pituitary-adrenal (HPA) response to daily repeated restraint stress (evaluated by plasma corticosterone levels), as well as on the effect of this procedure on anxiety-like behaviour, spatial learning and memory in the Morris water maze (MWM), a hippocampus-dependent task. Adult null mutant NK1-/- mice, with a C57BL/6J background, and the corresponding wild-type mice showed similar resting corticosterone levels and, also, did not differ in corticosterone response to a first restraint. Nevertheless, adaptation to the repeated stressor was faster in NK1-/- mice. Chronic restraint modestly increased anxiety-like behaviour in the light-dark test, irrespective of genotype. Throughout the days of the MWM trials, NK1-/- mice showed a similar learning rate to that of wild-type mice, but had lower levels of thigmotaxis and showed a better retention in the probe trial. Chronic restraint stress did not affect these variables in either genotype. These results indicate that deletion of the NK1 receptor does not alter behavioural susceptibility to chronic repeated stress in mice, but accelerates adaptation of the HPA axis. In addition, deletion may result in lower levels of thigmotaxis and improved short-term spatial memory, perhaps reflecting a better learning strategy in the MWM. © 2011 Elsevier Inc.
Fil: Delgado Morales, Raúl. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: del Río, Eva. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Gómez Román, Almudena. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Nadal, Roser. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
Fil: de Felipe, Carmen. Red de trastornos adictivos; España. Universidad Miguel Hernández; España
Fil: Armario, Antonio. Red de trastornos adictivos; España. Universitat Autònoma de Barcelona; España
description Brain substance P and its receptor (neurokinin-1, NK1) have a widespread brain distribution and are involved in an important number of behavioural and physiological responses to emotional stimuli. However, the role of NK1 receptors in the consequences of exposure to chronic stress has not been explored. The present study focused on the role of these receptors in the hypothalamic-pituitary-adrenal (HPA) response to daily repeated restraint stress (evaluated by plasma corticosterone levels), as well as on the effect of this procedure on anxiety-like behaviour, spatial learning and memory in the Morris water maze (MWM), a hippocampus-dependent task. Adult null mutant NK1-/- mice, with a C57BL/6J background, and the corresponding wild-type mice showed similar resting corticosterone levels and, also, did not differ in corticosterone response to a first restraint. Nevertheless, adaptation to the repeated stressor was faster in NK1-/- mice. Chronic restraint modestly increased anxiety-like behaviour in the light-dark test, irrespective of genotype. Throughout the days of the MWM trials, NK1-/- mice showed a similar learning rate to that of wild-type mice, but had lower levels of thigmotaxis and showed a better retention in the probe trial. Chronic restraint stress did not affect these variables in either genotype. These results indicate that deletion of the NK1 receptor does not alter behavioural susceptibility to chronic repeated stress in mice, but accelerates adaptation of the HPA axis. In addition, deletion may result in lower levels of thigmotaxis and improved short-term spatial memory, perhaps reflecting a better learning strategy in the MWM. © 2011 Elsevier Inc.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67548
Delgado Morales, Raúl; del Río, Eva; Gómez Román, Almudena; Bisagno, Veronica; Nadal, Roser; et al.; Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 105; 3; 2-2012; 669-675
0031-9384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67548
identifier_str_mv Delgado Morales, Raúl; del Río, Eva; Gómez Román, Almudena; Bisagno, Veronica; Nadal, Roser; et al.; Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 105; 3; 2-2012; 669-675
0031-9384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2011.10.008
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031938411004859
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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