GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration

Autores
Scolz, Massimilano; Widlund, Per O.; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; Peche, Leticia Y.; Ciani, Yari; Hubner, Nina; Isokane, Mayumi; Monte, Martin; Ellenberg, Jan; Hyman, Anthony A.; Schneider, Claudio; Bird, Alexander W.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.
Fil: Scolz, Massimilano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Widlund, Per O.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Piazza, Silvano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Bublik, Debora Rosa. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Reber, Simone. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Peche, Leticia Y.. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Ciani, Yari. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Hubner, Nina. Universitair Medisch Centrum Utrecht; Países Bajos
Fil: Isokane, Mayumi. European Molecular Biology Laboratory; Alemania
Fil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Ellenberg, Jan. European Molecular Biology Laboratory; Alemania
Fil: Hyman, Anthony A.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Schneider, Claudio. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia. University of Udine; Italia
Fil: Bird, Alexander W.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Materia
GTSE
MIGRACION
METASTASIS
MICROTUBULOS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66649
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/66649
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell MigrationScolz, MassimilanoWidlund, Per O.Piazza, SilvanoBublik, Debora RosaReber, SimonePeche, Leticia Y.Ciani, YariHubner, NinaIsokane, MayumiMonte, MartinEllenberg, JanHyman, Anthony A.Schneider, ClaudioBird, Alexander W.GTSEMIGRACIONMETASTASISMICROTUBULOShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.Fil: Scolz, Massimilano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Widlund, Per O.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Piazza, Silvano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Bublik, Debora Rosa. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Reber, Simone. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Peche, Leticia Y.. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Ciani, Yari. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Hubner, Nina. Universitair Medisch Centrum Utrecht; Países BajosFil: Isokane, Mayumi. European Molecular Biology Laboratory; AlemaniaFil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; ItaliaFil: Ellenberg, Jan. European Molecular Biology Laboratory; AlemaniaFil: Hyman, Anthony A.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Schneider, Claudio. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia. University of Udine; ItaliaFil: Bird, Alexander W.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaPublic Library of Science2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66649Scolz, Massimilano; Widlund, Per O.; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; et al.; GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration; Public Library of Science; Plos One; 7; 12; 12-2012; 51259-512651932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0051259info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051259info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:22:15Zoai:ri.conicet.gov.ar:11336/66649instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:22:15.389CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
title GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
spellingShingle GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
Scolz, Massimilano
GTSE
MIGRACION
METASTASIS
MICROTUBULOS
title_short GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
title_full GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
title_fullStr GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
title_full_unstemmed GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
title_sort GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
dc.creator.none.fl_str_mv Scolz, Massimilano
Widlund, Per O.
Piazza, Silvano
Bublik, Debora Rosa
Reber, Simone
Peche, Leticia Y.
Ciani, Yari
Hubner, Nina
Isokane, Mayumi
Monte, Martin
Ellenberg, Jan
Hyman, Anthony A.
Schneider, Claudio
Bird, Alexander W.
author Scolz, Massimilano
author_facet Scolz, Massimilano
Widlund, Per O.
Piazza, Silvano
Bublik, Debora Rosa
Reber, Simone
Peche, Leticia Y.
Ciani, Yari
Hubner, Nina
Isokane, Mayumi
Monte, Martin
Ellenberg, Jan
Hyman, Anthony A.
Schneider, Claudio
Bird, Alexander W.
author_role author
author2 Widlund, Per O.
Piazza, Silvano
Bublik, Debora Rosa
Reber, Simone
Peche, Leticia Y.
Ciani, Yari
Hubner, Nina
Isokane, Mayumi
Monte, Martin
Ellenberg, Jan
Hyman, Anthony A.
Schneider, Claudio
Bird, Alexander W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GTSE
MIGRACION
METASTASIS
MICROTUBULOS
topic GTSE
MIGRACION
METASTASIS
MICROTUBULOS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.
Fil: Scolz, Massimilano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Widlund, Per O.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Piazza, Silvano. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Bublik, Debora Rosa. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Reber, Simone. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Peche, Leticia Y.. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Ciani, Yari. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Hubner, Nina. Universitair Medisch Centrum Utrecht; Países Bajos
Fil: Isokane, Mayumi. European Molecular Biology Laboratory; Alemania
Fil: Monte, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia
Fil: Ellenberg, Jan. European Molecular Biology Laboratory; Alemania
Fil: Hyman, Anthony A.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Schneider, Claudio. Laboratorio Nazionale The Interuniversity Consortium for Biotechnology; Italia. University of Udine; Italia
Fil: Bird, Alexander W.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
description The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential. © 2012 Scolz et al.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66649
Scolz, Massimilano; Widlund, Per O.; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; et al.; GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration; Public Library of Science; Plos One; 7; 12; 12-2012; 51259-51265
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66649
identifier_str_mv Scolz, Massimilano; Widlund, Per O.; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; et al.; GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration; Public Library of Science; Plos One; 7; 12; 12-2012; 51259-51265
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0051259
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051259
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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