Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes

Autores
Salerno, Claudia; Chiappetta, Diego Andrés; Monteagudo, Ezequiel; Bregni, Carlos
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the inner aqueous phase and in the vesicular membrane, respectively. Niosomes are studied as an alternative to liposomes because they overcome the disadvantages associated with liposomes. The present study aimed to evaluate noisome formation from different surfactants and the encapsulation of amphotericin B as an amphiphilic model drug. Niosomes of Span 60®, Span 80®, Glyceryl monooleate, Dehydol® LS 2 HN (lauric alcohol 2EO) or Brij ®72 (Polyoxyethylene (2) Stearyl Ether) were prepared with the inclusion of cholesterol (ratio 1:1) by a modified ether injection technique. Two concentrations, 20 and 30 mM were studied. Span 60® and Span 80® 30mM formulations were the most stable and also the ones with higher entrapment capacity.
Fil: Salerno, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Materia
amphotericin B
niosomes
non-ionic surfactant
vesicular systems
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/109313
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in NiosomesSalerno, ClaudiaChiappetta, Diego AndrésMonteagudo, EzequielBregni, Carlosamphotericin Bniosomesnon-ionic surfactantvesicular systemshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the inner aqueous phase and in the vesicular membrane, respectively. Niosomes are studied as an alternative to liposomes because they overcome the disadvantages associated with liposomes. The present study aimed to evaluate noisome formation from different surfactants and the encapsulation of amphotericin B as an amphiphilic model drug. Niosomes of Span 60®, Span 80®, Glyceryl monooleate, Dehydol® LS 2 HN (lauric alcohol 2EO) or Brij ®72 (Polyoxyethylene (2) Stearyl Ether) were prepared with the inclusion of cholesterol (ratio 1:1) by a modified ether injection technique. Two concentrations, 20 and 30 mM were studied. Span 60® and Span 80® 30mM formulations were the most stable and also the ones with higher entrapment capacity.Fil: Salerno, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaColegio de Farmacéuticos de la Provincia de Buenos Aires2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/109313Salerno, Claudia; Chiappetta, Diego Andrés; Monteagudo, Ezequiel; Bregni, Carlos; Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 30; 9; 11-2011; 1728-17360326-2383CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://sedici.unlp.edu.ar/handle/10915/8366info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:14Zoai:ri.conicet.gov.ar:11336/109313instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:14.272CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
title Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
spellingShingle Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
Salerno, Claudia
amphotericin B
niosomes
non-ionic surfactant
vesicular systems
title_short Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
title_full Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
title_fullStr Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
title_full_unstemmed Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
title_sort Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes
dc.creator.none.fl_str_mv Salerno, Claudia
Chiappetta, Diego Andrés
Monteagudo, Ezequiel
Bregni, Carlos
author Salerno, Claudia
author_facet Salerno, Claudia
Chiappetta, Diego Andrés
Monteagudo, Ezequiel
Bregni, Carlos
author_role author
author2 Chiappetta, Diego Andrés
Monteagudo, Ezequiel
Bregni, Carlos
author2_role author
author
author
dc.subject.none.fl_str_mv amphotericin B
niosomes
non-ionic surfactant
vesicular systems
topic amphotericin B
niosomes
non-ionic surfactant
vesicular systems
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the inner aqueous phase and in the vesicular membrane, respectively. Niosomes are studied as an alternative to liposomes because they overcome the disadvantages associated with liposomes. The present study aimed to evaluate noisome formation from different surfactants and the encapsulation of amphotericin B as an amphiphilic model drug. Niosomes of Span 60®, Span 80®, Glyceryl monooleate, Dehydol® LS 2 HN (lauric alcohol 2EO) or Brij ®72 (Polyoxyethylene (2) Stearyl Ether) were prepared with the inclusion of cholesterol (ratio 1:1) by a modified ether injection technique. Two concentrations, 20 and 30 mM were studied. Span 60® and Span 80® 30mM formulations were the most stable and also the ones with higher entrapment capacity.
Fil: Salerno, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Monteagudo, Ezequiel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
description Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the inner aqueous phase and in the vesicular membrane, respectively. Niosomes are studied as an alternative to liposomes because they overcome the disadvantages associated with liposomes. The present study aimed to evaluate noisome formation from different surfactants and the encapsulation of amphotericin B as an amphiphilic model drug. Niosomes of Span 60®, Span 80®, Glyceryl monooleate, Dehydol® LS 2 HN (lauric alcohol 2EO) or Brij ®72 (Polyoxyethylene (2) Stearyl Ether) were prepared with the inclusion of cholesterol (ratio 1:1) by a modified ether injection technique. Two concentrations, 20 and 30 mM were studied. Span 60® and Span 80® 30mM formulations were the most stable and also the ones with higher entrapment capacity.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/109313
Salerno, Claudia; Chiappetta, Diego Andrés; Monteagudo, Ezequiel; Bregni, Carlos; Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 30; 9; 11-2011; 1728-1736
0326-2383
CONICET Digital
CONICET
url http://hdl.handle.net/11336/109313
identifier_str_mv Salerno, Claudia; Chiappetta, Diego Andrés; Monteagudo, Ezequiel; Bregni, Carlos; Influence of Surfactant Structure in the Encapsulation and Stability of Amphotericin B in Niosomes; Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 30; 9; 11-2011; 1728-1736
0326-2383
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://sedici.unlp.edu.ar/handle/10915/8366
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269789848862720
score 13.13397

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