Estrogen receptors and signaling pathways in lactotropes and somatotropes

Autores
Zarate, Sandra Cristina; Seilicovich, Adriana
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.
Fil: Zarate, Sandra Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Seilicovich, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Somatotropes
Signaling Pathways
Estrogens
Estrogen Receptors
Estrous Cycle
Pituitary
Prolactin
Lactotropes
Growth Hormone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15177
Acceder
id CONICETDig_d74fb566521aeab95b9454971200c642
oai_identifier_str oai:ri.conicet.gov.ar:11336/15177
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Estrogen receptors and signaling pathways in lactotropes and somatotropesZarate, Sandra CristinaSeilicovich, AdrianaSomatotropesSignaling PathwaysEstrogensEstrogen ReceptorsEstrous CyclePituitaryProlactinLactotropesGrowth Hormonehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.Fil: Zarate, Sandra Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Seilicovich, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaKarger2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15177Zarate, Sandra Cristina; Seilicovich, Adriana; Estrogen receptors and signaling pathways in lactotropes and somatotropes; Karger; Neuroendocrinology; 92; 4; 12-2010; 215-2230028-3835enginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/321683info:eu-repo/semantics/altIdentifier/doi/10.1159/000321683info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:44:00Zoai:ri.conicet.gov.ar:11336/15177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:44:00.262CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Estrogen receptors and signaling pathways in lactotropes and somatotropes
title Estrogen receptors and signaling pathways in lactotropes and somatotropes
spellingShingle Estrogen receptors and signaling pathways in lactotropes and somatotropes
Zarate, Sandra Cristina
Somatotropes
Signaling Pathways
Estrogens
Estrogen Receptors
Estrous Cycle
Pituitary
Prolactin
Lactotropes
Growth Hormone
title_short Estrogen receptors and signaling pathways in lactotropes and somatotropes
title_full Estrogen receptors and signaling pathways in lactotropes and somatotropes
title_fullStr Estrogen receptors and signaling pathways in lactotropes and somatotropes
title_full_unstemmed Estrogen receptors and signaling pathways in lactotropes and somatotropes
title_sort Estrogen receptors and signaling pathways in lactotropes and somatotropes
dc.creator.none.fl_str_mv Zarate, Sandra Cristina
Seilicovich, Adriana
author Zarate, Sandra Cristina
author_facet Zarate, Sandra Cristina
Seilicovich, Adriana
author_role author
author2 Seilicovich, Adriana
author2_role author
dc.subject.none.fl_str_mv Somatotropes
Signaling Pathways
Estrogens
Estrogen Receptors
Estrous Cycle
Pituitary
Prolactin
Lactotropes
Growth Hormone
topic Somatotropes
Signaling Pathways
Estrogens
Estrogen Receptors
Estrous Cycle
Pituitary
Prolactin
Lactotropes
Growth Hormone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.
Fil: Zarate, Sandra Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Seilicovich, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15177
Zarate, Sandra Cristina; Seilicovich, Adriana; Estrogen receptors and signaling pathways in lactotropes and somatotropes; Karger; Neuroendocrinology; 92; 4; 12-2010; 215-223
0028-3835
url http://hdl.handle.net/11336/15177
identifier_str_mv Zarate, Sandra Cristina; Seilicovich, Adriana; Estrogen receptors and signaling pathways in lactotropes and somatotropes; Karger; Neuroendocrinology; 92; 4; 12-2010; 215-223
0028-3835
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/321683
info:eu-repo/semantics/altIdentifier/doi/10.1159/000321683
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782133331296256
score 12.982451

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