Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats
- Autores
- Candolfi, Marianela; Zaldivar, Verónica; de Laurentiis, Andrea; Jaita, Gabriela Alejandra; Pisera, Daniel Alberto; Seilicovich, Adriana
- Año de publicación
- 2002
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- TNF-α is involved in the regulation of normal tissue homeostasis affecting cell proliferation, differentiation, and death. We previously reported that TNF-α reduces anterior pituitary cell proliferation and PRL release in an estrogen-dependent manner. In the present project we studied the induction of apoptosis by TNF-α in anterior pituitary cells from female rats. TNF-α (50 ng/ml) decreased the viability of anterior pituitary cells. Incubation with TNF-α for 24 h increased the percentage of terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling-positive cells. TNF-α increased the percentage of somatotropes and lactotropes with apoptotic nuclear morphology without affecting the proportion of apoptotic corticotropes or gonadotropes. TNF-α increased the percentage of apoptotic lactotropes in cultured cells from rats killed in proestrus and estrus, but not in diestrus. This effect was significantly higher in cells from rats in proestrus than in estrus. In anterior pituitary cells from ovariectomized rats, TNF-α significantly increased the percentage of apoptotic lactotropes only when the cells were incubated in the presence of 17β-estradiol. These results indicate that TNF-α induces apoptosis in somatotropes and lactotropes from female rats. The apoptotic effect of TNF-α on lactotropes is dependent on estrogens and could be involved in the regulation of anterior pituitary cell renewal during the estrous cycle.
Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Zaldivar, Verónica. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Laurentiis, Andrea. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jaita, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina - Materia
-
TNF
LACTOTROPES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/170659
Ver los metadatos del registro completo
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Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female ratsCandolfi, MarianelaZaldivar, Verónicade Laurentiis, AndreaJaita, Gabriela AlejandraPisera, Daniel AlbertoSeilicovich, AdrianaTNFLACTOTROPEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3TNF-α is involved in the regulation of normal tissue homeostasis affecting cell proliferation, differentiation, and death. We previously reported that TNF-α reduces anterior pituitary cell proliferation and PRL release in an estrogen-dependent manner. In the present project we studied the induction of apoptosis by TNF-α in anterior pituitary cells from female rats. TNF-α (50 ng/ml) decreased the viability of anterior pituitary cells. Incubation with TNF-α for 24 h increased the percentage of terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling-positive cells. TNF-α increased the percentage of somatotropes and lactotropes with apoptotic nuclear morphology without affecting the proportion of apoptotic corticotropes or gonadotropes. TNF-α increased the percentage of apoptotic lactotropes in cultured cells from rats killed in proestrus and estrus, but not in diestrus. This effect was significantly higher in cells from rats in proestrus than in estrus. In anterior pituitary cells from ovariectomized rats, TNF-α significantly increased the percentage of apoptotic lactotropes only when the cells were incubated in the presence of 17β-estradiol. These results indicate that TNF-α induces apoptosis in somatotropes and lactotropes from female rats. The apoptotic effect of TNF-α on lactotropes is dependent on estrogens and could be involved in the regulation of anterior pituitary cell renewal during the estrous cycle.Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Zaldivar, Verónica. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Laurentiis, Andrea. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jaita, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaEndocrine Society2002-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170659Candolfi, Marianela; Zaldivar, Verónica; de Laurentiis, Andrea; Jaita, Gabriela Alejandra; Pisera, Daniel Alberto; et al.; Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats; Endocrine Society; Endocrinology; 143; 9; 9-2002; 3611-36170013-7227CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2002-220377info:eu-repo/semantics/altIdentifier/doi/10.1210/en.2002-220377info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:41Zoai:ri.conicet.gov.ar:11336/170659instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:41.881CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
title |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
spellingShingle |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats Candolfi, Marianela TNF LACTOTROPES |
title_short |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
title_full |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
title_fullStr |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
title_full_unstemmed |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
title_sort |
Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats |
dc.creator.none.fl_str_mv |
Candolfi, Marianela Zaldivar, Verónica de Laurentiis, Andrea Jaita, Gabriela Alejandra Pisera, Daniel Alberto Seilicovich, Adriana |
author |
Candolfi, Marianela |
author_facet |
Candolfi, Marianela Zaldivar, Verónica de Laurentiis, Andrea Jaita, Gabriela Alejandra Pisera, Daniel Alberto Seilicovich, Adriana |
author_role |
author |
author2 |
Zaldivar, Verónica de Laurentiis, Andrea Jaita, Gabriela Alejandra Pisera, Daniel Alberto Seilicovich, Adriana |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
TNF LACTOTROPES |
topic |
TNF LACTOTROPES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
TNF-α is involved in the regulation of normal tissue homeostasis affecting cell proliferation, differentiation, and death. We previously reported that TNF-α reduces anterior pituitary cell proliferation and PRL release in an estrogen-dependent manner. In the present project we studied the induction of apoptosis by TNF-α in anterior pituitary cells from female rats. TNF-α (50 ng/ml) decreased the viability of anterior pituitary cells. Incubation with TNF-α for 24 h increased the percentage of terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling-positive cells. TNF-α increased the percentage of somatotropes and lactotropes with apoptotic nuclear morphology without affecting the proportion of apoptotic corticotropes or gonadotropes. TNF-α increased the percentage of apoptotic lactotropes in cultured cells from rats killed in proestrus and estrus, but not in diestrus. This effect was significantly higher in cells from rats in proestrus than in estrus. In anterior pituitary cells from ovariectomized rats, TNF-α significantly increased the percentage of apoptotic lactotropes only when the cells were incubated in the presence of 17β-estradiol. These results indicate that TNF-α induces apoptosis in somatotropes and lactotropes from female rats. The apoptotic effect of TNF-α on lactotropes is dependent on estrogens and could be involved in the regulation of anterior pituitary cell renewal during the estrous cycle. Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Zaldivar, Verónica. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: de Laurentiis, Andrea. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Jaita, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Pisera, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Seilicovich, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina |
description |
TNF-α is involved in the regulation of normal tissue homeostasis affecting cell proliferation, differentiation, and death. We previously reported that TNF-α reduces anterior pituitary cell proliferation and PRL release in an estrogen-dependent manner. In the present project we studied the induction of apoptosis by TNF-α in anterior pituitary cells from female rats. TNF-α (50 ng/ml) decreased the viability of anterior pituitary cells. Incubation with TNF-α for 24 h increased the percentage of terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling-positive cells. TNF-α increased the percentage of somatotropes and lactotropes with apoptotic nuclear morphology without affecting the proportion of apoptotic corticotropes or gonadotropes. TNF-α increased the percentage of apoptotic lactotropes in cultured cells from rats killed in proestrus and estrus, but not in diestrus. This effect was significantly higher in cells from rats in proestrus than in estrus. In anterior pituitary cells from ovariectomized rats, TNF-α significantly increased the percentage of apoptotic lactotropes only when the cells were incubated in the presence of 17β-estradiol. These results indicate that TNF-α induces apoptosis in somatotropes and lactotropes from female rats. The apoptotic effect of TNF-α on lactotropes is dependent on estrogens and could be involved in the regulation of anterior pituitary cell renewal during the estrous cycle. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/170659 Candolfi, Marianela; Zaldivar, Verónica; de Laurentiis, Andrea; Jaita, Gabriela Alejandra; Pisera, Daniel Alberto; et al.; Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats; Endocrine Society; Endocrinology; 143; 9; 9-2002; 3611-3617 0013-7227 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/170659 |
identifier_str_mv |
Candolfi, Marianela; Zaldivar, Verónica; de Laurentiis, Andrea; Jaita, Gabriela Alejandra; Pisera, Daniel Alberto; et al.; Tumor Necrosis Factor-alpha induces apoptosis of lactotropes from female rats; Endocrine Society; Endocrinology; 143; 9; 9-2002; 3611-3617 0013-7227 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2002-220377 info:eu-repo/semantics/altIdentifier/doi/10.1210/en.2002-220377 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Endocrine Society |
publisher.none.fl_str_mv |
Endocrine Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613769282453504 |
score |
13.070432 |