Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
- Autores
- Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; Mizzen, Lee; Dominici, Fernando Pablo
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.
Fil: Toblli, Jorge Eduardo. Hospital Alemán; Argentina
Fil: Rivas, Carlos. Hospital Alemán; Argentina
Fil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
Fil: Funk, Felix. Vifor; Suiza
Fil: Mizzen, Lee. Vifor Pharma; Canadá
Fil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina - Materia
-
anemia
cardiotoxicidad
hierro endovenoso
quimioterapia - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/7909
Ver los metadatos del registro completo
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Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat modelToblli, Jorge EduardoRivas, CarlosCao, Gabriel FernandoGiani, Jorge FernandoFunk, FelixMizzen, LeeDominici, Fernando Pabloanemiacardiotoxicidadhierro endovenosoquimioterapiahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.Fil: Toblli, Jorge Eduardo. Hospital Alemán; ArgentinaFil: Rivas, Carlos. Hospital Alemán; ArgentinaFil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaFil: Funk, Felix. Vifor; SuizaFil: Mizzen, Lee. Vifor Pharma; CanadáFil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaHindawi Publishing Corporation2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7909Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-102090-2107enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cherp/2014/570241/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/570241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:51Zoai:ri.conicet.gov.ar:11336/7909instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:52.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
title |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
spellingShingle |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model Toblli, Jorge Eduardo anemia cardiotoxicidad hierro endovenoso quimioterapia |
title_short |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
title_full |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
title_fullStr |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
title_full_unstemmed |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
title_sort |
Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model |
dc.creator.none.fl_str_mv |
Toblli, Jorge Eduardo Rivas, Carlos Cao, Gabriel Fernando Giani, Jorge Fernando Funk, Felix Mizzen, Lee Dominici, Fernando Pablo |
author |
Toblli, Jorge Eduardo |
author_facet |
Toblli, Jorge Eduardo Rivas, Carlos Cao, Gabriel Fernando Giani, Jorge Fernando Funk, Felix Mizzen, Lee Dominici, Fernando Pablo |
author_role |
author |
author2 |
Rivas, Carlos Cao, Gabriel Fernando Giani, Jorge Fernando Funk, Felix Mizzen, Lee Dominici, Fernando Pablo |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
anemia cardiotoxicidad hierro endovenoso quimioterapia |
topic |
anemia cardiotoxicidad hierro endovenoso quimioterapia |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC. Fil: Toblli, Jorge Eduardo. Hospital Alemán; Argentina Fil: Rivas, Carlos. Hospital Alemán; Argentina Fil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina Fil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina Fil: Funk, Felix. Vifor; Suiza Fil: Mizzen, Lee. Vifor Pharma; Canadá Fil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina |
description |
Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/7909 Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-10 2090-2107 |
url |
http://hdl.handle.net/11336/7909 |
identifier_str_mv |
Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-10 2090-2107 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cherp/2014/570241/ info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/570241 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613515783962624 |
score |
13.070432 |