Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model

Autores
Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; Mizzen, Lee; Dominici, Fernando Pablo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.
Fil: Toblli, Jorge Eduardo. Hospital Alemán; Argentina
Fil: Rivas, Carlos. Hospital Alemán; Argentina
Fil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
Fil: Funk, Felix. Vifor; Suiza
Fil: Mizzen, Lee. Vifor Pharma; Canadá
Fil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
Materia
anemia
cardiotoxicidad
hierro endovenoso
quimioterapia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7909
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7909
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat modelToblli, Jorge EduardoRivas, CarlosCao, Gabriel FernandoGiani, Jorge FernandoFunk, FelixMizzen, LeeDominici, Fernando Pabloanemiacardiotoxicidadhierro endovenosoquimioterapiahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.Fil: Toblli, Jorge Eduardo. Hospital Alemán; ArgentinaFil: Rivas, Carlos. Hospital Alemán; ArgentinaFil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaFil: Funk, Felix. Vifor; SuizaFil: Mizzen, Lee. Vifor Pharma; CanadáFil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; ArgentinaHindawi Publishing Corporation2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7909Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-102090-2107enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cherp/2014/570241/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/570241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:18:16Zoai:ri.conicet.gov.ar:11336/7909instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:18:17.257CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
title Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
spellingShingle Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
Toblli, Jorge Eduardo
anemia
cardiotoxicidad
hierro endovenoso
quimioterapia
title_short Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
title_full Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
title_fullStr Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
title_full_unstemmed Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
title_sort Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model
dc.creator.none.fl_str_mv Toblli, Jorge Eduardo
Rivas, Carlos
Cao, Gabriel Fernando
Giani, Jorge Fernando
Funk, Felix
Mizzen, Lee
Dominici, Fernando Pablo
author Toblli, Jorge Eduardo
author_facet Toblli, Jorge Eduardo
Rivas, Carlos
Cao, Gabriel Fernando
Giani, Jorge Fernando
Funk, Felix
Mizzen, Lee
Dominici, Fernando Pablo
author_role author
author2 Rivas, Carlos
Cao, Gabriel Fernando
Giani, Jorge Fernando
Funk, Felix
Mizzen, Lee
Dominici, Fernando Pablo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv anemia
cardiotoxicidad
hierro endovenoso
quimioterapia
topic anemia
cardiotoxicidad
hierro endovenoso
quimioterapia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.
Fil: Toblli, Jorge Eduardo. Hospital Alemán; Argentina
Fil: Rivas, Carlos. Hospital Alemán; Argentina
Fil: Cao, Gabriel Fernando. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Giani, Jorge Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
Fil: Funk, Felix. Vifor; Suiza
Fil: Mizzen, Lee. Vifor Pharma; Canadá
Fil: Dominici, Fernando Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Fisicoquímica Biológicas; Argentina
description Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. his study evaluated how intravenous ferric carboxymaltose (FCM) modulates the inluence of iron deiciency anaemia (IDA) and doxorubicin (3?5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inlammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15mg iron per kg BW), either concurrent with or three days ater doxorubicin. IDA (ater dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inlammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (let ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin. Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal efects of IDA and doxorubicin independent of the iron dosing regimen. he results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7909
Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-10
2090-2107
url http://hdl.handle.net/11336/7909
identifier_str_mv Toblli, Jorge Eduardo; Rivas, Carlos; Cao, Gabriel Fernando; Giani, Jorge Fernando; Funk, Felix; et al.; Ferric carboxymaltose-mediated attenuation of Doxorubicin-induced cardiotoxicity in an iron deficiency rat model; Hindawi Publishing Corporation; Chemotherapy Research and Practice; 2014; 4-2014; 1-10
2090-2107
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cherp/2014/570241/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/570241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781643840290816
score 12.982451

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