Variations in AXIN2 predict risk and prognosis of colorectal cancer

Autores
Otero, L.; Lacunza, Ezequiel; Vasquez, V.; Arbelaez, V.; Cardier, F.; González, F.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. Patients and methods: This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. Results: AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7–10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22–6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. Conclusions: These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.
Fil: Otero, L.. Pontificia Universidad Javeriana; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Vasquez, V.. Pontificia Universidad Javeriana; Colombia
Fil: Arbelaez, V.. No especifíca;
Fil: Cardier, F.. Pontificia Universidad Javeriana; Colombia
Fil: González, F.. No especifíca;
Materia
AXIN2
Polymorphism
Colorectal cancer
Hypodonthia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129843
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Variations in AXIN2 predict risk and prognosis of colorectal cancerOtero, L.Lacunza, EzequielVasquez, V.Arbelaez, V.Cardier, F.González, F.AXIN2PolymorphismColorectal cancerHypodonthiahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. Patients and methods: This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. Results: AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7–10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22–6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. Conclusions: These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.Fil: Otero, L.. Pontificia Universidad Javeriana; ColombiaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Vasquez, V.. Pontificia Universidad Javeriana; ColombiaFil: Arbelaez, V.. No especifíca;Fil: Cardier, F.. Pontificia Universidad Javeriana; ColombiaFil: González, F.. No especifíca;Springer2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129843Otero, L.; Lacunza, Ezequiel; Vasquez, V.; Arbelaez, V.; Cardier, F.; et al.; Variations in AXIN2 predict risk and prognosis of colorectal cancer; Springer; BDJ Open; 5; 1; 12-2019; 1-62056-807XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41405-019-0022-zinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41405-019-0022-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:26:32Zoai:ri.conicet.gov.ar:11336/129843instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:26:32.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Variations in AXIN2 predict risk and prognosis of colorectal cancer
title Variations in AXIN2 predict risk and prognosis of colorectal cancer
spellingShingle Variations in AXIN2 predict risk and prognosis of colorectal cancer
Otero, L.
AXIN2
Polymorphism
Colorectal cancer
Hypodonthia
title_short Variations in AXIN2 predict risk and prognosis of colorectal cancer
title_full Variations in AXIN2 predict risk and prognosis of colorectal cancer
title_fullStr Variations in AXIN2 predict risk and prognosis of colorectal cancer
title_full_unstemmed Variations in AXIN2 predict risk and prognosis of colorectal cancer
title_sort Variations in AXIN2 predict risk and prognosis of colorectal cancer
dc.creator.none.fl_str_mv Otero, L.
Lacunza, Ezequiel
Vasquez, V.
Arbelaez, V.
Cardier, F.
González, F.
author Otero, L.
author_facet Otero, L.
Lacunza, Ezequiel
Vasquez, V.
Arbelaez, V.
Cardier, F.
González, F.
author_role author
author2 Lacunza, Ezequiel
Vasquez, V.
Arbelaez, V.
Cardier, F.
González, F.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AXIN2
Polymorphism
Colorectal cancer
Hypodonthia
topic AXIN2
Polymorphism
Colorectal cancer
Hypodonthia
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. Patients and methods: This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. Results: AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7–10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22–6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. Conclusions: These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.
Fil: Otero, L.. Pontificia Universidad Javeriana; Colombia
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Vasquez, V.. Pontificia Universidad Javeriana; Colombia
Fil: Arbelaez, V.. No especifíca;
Fil: Cardier, F.. Pontificia Universidad Javeriana; Colombia
Fil: González, F.. No especifíca;
description Objective: Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. Patients and methods: This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. Results: AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7–10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22–6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. Conclusions: These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129843
Otero, L.; Lacunza, Ezequiel; Vasquez, V.; Arbelaez, V.; Cardier, F.; et al.; Variations in AXIN2 predict risk and prognosis of colorectal cancer; Springer; BDJ Open; 5; 1; 12-2019; 1-6
2056-807X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129843
identifier_str_mv Otero, L.; Lacunza, Ezequiel; Vasquez, V.; Arbelaez, V.; Cardier, F.; et al.; Variations in AXIN2 predict risk and prognosis of colorectal cancer; Springer; BDJ Open; 5; 1; 12-2019; 1-6
2056-807X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41405-019-0022-z
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41405-019-0022-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.238319

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