Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas

Autores
Moscoso Vásquez, Hilda Marcela; Colmegna, Patricio Hernán; Rosales, Nicolás; Garelli, Fabricio; Sanchez Peña, Ricardo Salvador
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM controloriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation.
Fil: Moscoso Vásquez, Hilda Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina
Fil: Colmegna, Patricio Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Rosales, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina
Materia
Intra-patient variations
LPV model
Control-oriented model
Type 1 diabetes
Artificial pancreas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146385
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Control-Oriented Model with Intra-Patient Variations for an Artificial PancreasMoscoso Vásquez, Hilda MarcelaColmegna, Patricio HernánRosales, NicolásGarelli, FabricioSanchez Peña, Ricardo SalvadorIntra-patient variationsLPV modelControl-oriented modelType 1 diabetesArtificial pancreashttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM controloriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation.Fil: Moscoso Vásquez, Hilda Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; ArgentinaFil: Colmegna, Patricio Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Rosales, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Sanchez Peña, Ricardo Salvador. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; ArgentinaInstitute of Electrical and Electronics Engineers2020-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146385Moscoso Vásquez, Hilda Marcela; Colmegna, Patricio Hernán; Rosales, Nicolás; Garelli, Fabricio; Sanchez Peña, Ricardo Salvador; Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas; Institute of Electrical and Electronics Engineers; IEEE Journal of Biomedical and Health Informatics; 24; 9; 27-1-2020; 2681 - 26892168-21942168-2208CONICET DigitalCONICETenghttp://hdl.handle.net/11336/81293info:eu-repo/semantics/altIdentifier/url/https://ieeexplore.ieee.org/document/8970365/info:eu-repo/semantics/altIdentifier/doi/10.1109/JBHI.2020.2969389info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:40Zoai:ri.conicet.gov.ar:11336/146385instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:40.613CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
title Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
spellingShingle Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
Moscoso Vásquez, Hilda Marcela
Intra-patient variations
LPV model
Control-oriented model
Type 1 diabetes
Artificial pancreas
title_short Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
title_full Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
title_fullStr Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
title_full_unstemmed Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
title_sort Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas
dc.creator.none.fl_str_mv Moscoso Vásquez, Hilda Marcela
Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sanchez Peña, Ricardo Salvador
author Moscoso Vásquez, Hilda Marcela
author_facet Moscoso Vásquez, Hilda Marcela
Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sanchez Peña, Ricardo Salvador
author_role author
author2 Colmegna, Patricio Hernán
Rosales, Nicolás
Garelli, Fabricio
Sanchez Peña, Ricardo Salvador
author2_role author
author
author
author
dc.subject.none.fl_str_mv Intra-patient variations
LPV model
Control-oriented model
Type 1 diabetes
Artificial pancreas
topic Intra-patient variations
LPV model
Control-oriented model
Type 1 diabetes
Artificial pancreas
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM controloriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation.
Fil: Moscoso Vásquez, Hilda Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina
Fil: Colmegna, Patricio Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Virginia; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Rosales, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires. Departamento de Matemática. Centro de Sistemas y Control; Argentina
description In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM controloriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-27
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146385
Moscoso Vásquez, Hilda Marcela; Colmegna, Patricio Hernán; Rosales, Nicolás; Garelli, Fabricio; Sanchez Peña, Ricardo Salvador; Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas; Institute of Electrical and Electronics Engineers; IEEE Journal of Biomedical and Health Informatics; 24; 9; 27-1-2020; 2681 - 2689
2168-2194
2168-2208
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146385
identifier_str_mv Moscoso Vásquez, Hilda Marcela; Colmegna, Patricio Hernán; Rosales, Nicolás; Garelli, Fabricio; Sanchez Peña, Ricardo Salvador; Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas; Institute of Electrical and Electronics Engineers; IEEE Journal of Biomedical and Health Informatics; 24; 9; 27-1-2020; 2681 - 2689
2168-2194
2168-2208
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://hdl.handle.net/11336/81293
info:eu-repo/semantics/altIdentifier/url/https://ieeexplore.ieee.org/document/8970365/
info:eu-repo/semantics/altIdentifier/doi/10.1109/JBHI.2020.2969389
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269768403386368
score 13.13397

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