SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

Autores
Salinas Calderon, Valeria Macarena; Villarroel, Juana; Silva, Hernán; Herrera, Luisa; Jerez, Sonia; Zazueta, Alejandra; Montes, Cristián; Nieto, Rodrigo; Bustamante, M. Leonor
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.
Fil: Salinas Calderon, Valeria Macarena. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Villarroel, Juana. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Silva, Hernán. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Herrera, Luisa. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Jerez, Sonia. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Zazueta, Alejandra. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Montes, Cristián. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Nieto, Rodrigo. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Bustamante, M. Leonor. Universidad de Chile. Facultad de Medicina.; Chile
Materia
Personality traits
5-factor model
5HTTLPR
Genic interaction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/246417
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorderSalinas Calderon, Valeria MacarenaVillarroel, JuanaSilva, HernánHerrera, LuisaJerez, SoniaZazueta, AlejandraMontes, CristiánNieto, RodrigoBustamante, M. LeonorPersonality traits5-factor model5HTTLPRGenic interactionhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.Fil: Salinas Calderon, Valeria Macarena. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Villarroel, Juana. Universidad de Chile. Facultad de Medicina.; ChileFil: Silva, Hernán. Universidad de Chile. Facultad de Medicina.; ChileFil: Herrera, Luisa. Universidad de Chile. Facultad de Medicina.; ChileFil: Jerez, Sonia. Universidad de Chile. Facultad de Medicina.; ChileFil: Zazueta, Alejandra. Universidad de Chile. Facultad de Medicina.; ChileFil: Montes, Cristián. Universidad de Chile. Facultad de Medicina.; ChileFil: Nieto, Rodrigo. Universidad de Chile. Facultad de Medicina.; ChileFil: Bustamante, M. Leonor. Universidad de Chile. Facultad de Medicina.; ChileBioMed Central2020-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246417Salinas Calderon, Valeria Macarena; Villarroel, Juana; Silva, Hernán; Herrera, Luisa; Jerez, Sonia; et al.; SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder; BioMed Central; BMC Research Notes; 13; 1; 2-2020; 1-51756-0500CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-4924-6info:eu-repo/semantics/altIdentifier/doi/10.1186/s13104-020-4924-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:52:13Zoai:ri.conicet.gov.ar:11336/246417instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:52:13.932CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
title SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
spellingShingle SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
Salinas Calderon, Valeria Macarena
Personality traits
5-factor model
5HTTLPR
Genic interaction
title_short SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
title_full SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
title_fullStr SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
title_full_unstemmed SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
title_sort SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
dc.creator.none.fl_str_mv Salinas Calderon, Valeria Macarena
Villarroel, Juana
Silva, Hernán
Herrera, Luisa
Jerez, Sonia
Zazueta, Alejandra
Montes, Cristián
Nieto, Rodrigo
Bustamante, M. Leonor
author Salinas Calderon, Valeria Macarena
author_facet Salinas Calderon, Valeria Macarena
Villarroel, Juana
Silva, Hernán
Herrera, Luisa
Jerez, Sonia
Zazueta, Alejandra
Montes, Cristián
Nieto, Rodrigo
Bustamante, M. Leonor
author_role author
author2 Villarroel, Juana
Silva, Hernán
Herrera, Luisa
Jerez, Sonia
Zazueta, Alejandra
Montes, Cristián
Nieto, Rodrigo
Bustamante, M. Leonor
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Personality traits
5-factor model
5HTTLPR
Genic interaction
topic Personality traits
5-factor model
5HTTLPR
Genic interaction
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.
Fil: Salinas Calderon, Valeria Macarena. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Villarroel, Juana. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Silva, Hernán. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Herrera, Luisa. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Jerez, Sonia. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Zazueta, Alejandra. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Montes, Cristián. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Nieto, Rodrigo. Universidad de Chile. Facultad de Medicina.; Chile
Fil: Bustamante, M. Leonor. Universidad de Chile. Facultad de Medicina.; Chile
description Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.
publishDate 2020
dc.date.none.fl_str_mv 2020-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/246417
Salinas Calderon, Valeria Macarena; Villarroel, Juana; Silva, Hernán; Herrera, Luisa; Jerez, Sonia; et al.; SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder; BioMed Central; BMC Research Notes; 13; 1; 2-2020; 1-5
1756-0500
CONICET Digital
CONICET
url http://hdl.handle.net/11336/246417
identifier_str_mv Salinas Calderon, Valeria Macarena; Villarroel, Juana; Silva, Hernán; Herrera, Luisa; Jerez, Sonia; et al.; SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder; BioMed Central; BMC Research Notes; 13; 1; 2-2020; 1-5
1756-0500
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-4924-6
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13104-020-4924-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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