Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)

Autores
Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; Lo Nostro, Fabiana Laura
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature.
Fil: Da Cuña, Rodrigo Hernán. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pandolfi, Matias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología y Comportamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genovese, Griselda. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piazza, Yanina Grisel. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ansaldo, Martín. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina
Fil: Lo Nostro, Fabiana Laura. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Endosulfan
Cichlid Fish
Endocrine Disruption
Testes Pathology
Gonadotropins
Sex Steroids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12679
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12679
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)Da Cuña, Rodrigo HernánPandolfi, MatiasGenovese, GriseldaPiazza, Yanina GriselAnsaldo, MartínLo Nostro, Fabiana LauraEndosulfanCichlid FishEndocrine DisruptionTestes PathologyGonadotropinsSex Steroidshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature.Fil: Da Cuña, Rodrigo Hernán. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pandolfi, Matias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología y Comportamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Genovese, Griselda. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Piazza, Yanina Grisel. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ansaldo, Martín. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; ArgentinaFil: Lo Nostro, Fabiana Laura. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12679Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; et al.; Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae); Elsevier Science; Aquatic Toxicology; 126; 1-2013; 299-3050166-445Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166445X12002767info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2012.09.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:54Zoai:ri.conicet.gov.ar:11336/12679instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:55.058CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
title Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
spellingShingle Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
Da Cuña, Rodrigo Hernán
Endosulfan
Cichlid Fish
Endocrine Disruption
Testes Pathology
Gonadotropins
Sex Steroids
title_short Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
title_full Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
title_fullStr Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
title_full_unstemmed Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
title_sort Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae)
dc.creator.none.fl_str_mv Da Cuña, Rodrigo Hernán
Pandolfi, Matias
Genovese, Griselda
Piazza, Yanina Grisel
Ansaldo, Martín
Lo Nostro, Fabiana Laura
author Da Cuña, Rodrigo Hernán
author_facet Da Cuña, Rodrigo Hernán
Pandolfi, Matias
Genovese, Griselda
Piazza, Yanina Grisel
Ansaldo, Martín
Lo Nostro, Fabiana Laura
author_role author
author2 Pandolfi, Matias
Genovese, Griselda
Piazza, Yanina Grisel
Ansaldo, Martín
Lo Nostro, Fabiana Laura
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Endosulfan
Cichlid Fish
Endocrine Disruption
Testes Pathology
Gonadotropins
Sex Steroids
topic Endosulfan
Cichlid Fish
Endocrine Disruption
Testes Pathology
Gonadotropins
Sex Steroids
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature.
Fil: Da Cuña, Rodrigo Hernán. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pandolfi, Matias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología y Comportamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Genovese, Griselda. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piazza, Yanina Grisel. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ansaldo, Martín. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina
Fil: Lo Nostro, Fabiana Laura. Universidad de Buenos Aires. Facultad de Cs.exactas y Naturales. Departamento de Biodiversidad y Biologia Experimental. Laboratorio de Ecotoxicologia Acuatica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Endosulfan (ES), a persistent organochlorine pesticide, is widely used worldwide despite its toxicity to non-target animals. Upon reaching water bodies, ES can cause negative effects on aquatic animals, including disruption of hormonal systems. However, the action of ES on fish reproductive axis has been hardly studied thus far. The aim of the present work was to analyze the endocrine disruptive potential of endosulfan on the pituitary gonadotropins levels and on the testes function due to ES in the South American freshwater fish Cichlasoma dimerus, using in vivo and in vitro approaches. Waterborne ES (0.1, 0.3 and 1 g/L) exposure for two months caused decrease in FSH pituitary content and GT activity in the testes (Sertoli cell function marker). Testicular alterations such as scarce intermediate stages of spermatogenesis, release of immature germ cells into the lobular lumen, presence of foam cells and interstitial fibrosis, were also observed. In vitro experiments showed that ES inhibited the LH-stimulated steroidogenesis in gonads. As FSH and FSH-mediated steroidogenesis regulate spermatogenesis and Sertoli cell function, the effect of ES on FSH could be responsible for the morphological alterations observed in testes. Direct effects can also be occurring through disruption of steroidogenesis, as observed in vitro. Based on this evidence, ES exhibits an endocrine disruptive action on the reproductive axis of C. dimerus, causing disruption at the pituitary and/or at the gonad level. These effects could acquire greater significance under prolonged exposure to the pesticide in nature.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12679
Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; et al.; Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae); Elsevier Science; Aquatic Toxicology; 126; 1-2013; 299-305
0166-445X
url http://hdl.handle.net/11336/12679
identifier_str_mv Da Cuña, Rodrigo Hernán; Pandolfi, Matias; Genovese, Griselda; Piazza, Yanina Grisel; Ansaldo, Martín; et al.; Endocrine disruptive potential of endosulfan on the reproductive axis of C. dimerus (Perciformes, Cichlidae); Elsevier Science; Aquatic Toxicology; 126; 1-2013; 299-305
0166-445X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166445X12002767
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2012.09.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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