Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas

Autores: Legaz, Agustina; Altschuler, Florencia; Gonzalez Gomez, Raul; Hernández, Hernán; Baez, Sandra; Migeot, Joaquín; Fittipaldi, María Sol; Medel, Vicente; Maito, Marcelo Adrián; Godoy, María Eugenia; Moguilner, Sebastián; Cruzat, Josephine; Coronel Oliveros, Carlos; Tagliazuchi, Enzo; Santamaria Garcia, Hernando; Farina, Francesca R.; Reyes, Pablo; Javandel, Shireen; García, Adolfo Martín; Deleglise, Álvaro; Matallana, Diana L.; Avila Funes, José Alberto; Slachevsky, Andrea; Behrens, María I.; Possin, Katherine L.; Lawlor, Brian; Valcour, Victor; Yokoyama, Jennifer S.; Miller, Bruce; Ibañez, Agustin
Año de publicación: 2024
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations.
Fil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Altschuler, Florencia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina
Fil: Hernández, Hernán. Universidad Adolfo Ibañez; Chile
Fil: Baez, Sandra. Trinity College Dublin; Irlanda. Universidad de los Andes; Colombia
Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda
Fil: Fittipaldi, María Sol. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medel, Vicente. Universidad Adolfo Ibañez; Chile
Fil: Maito, Marcelo Adrián. Universidad de San Andrés; Argentina
Fil: Godoy, María Eugenia. Universidad de San Andrés; Argentina
Fil: Moguilner, Sebastián. Trinity College Dublin; Irlanda
Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile
Fil: Coronel Oliveros, Carlos. Trinity College Dublin; Irlanda
Fil: Tagliazuchi, Enzo. Universidad Adolfo Ibañez; Chile
Fil: Santamaria Garcia, Hernando. Hospital Universitario San Ignacio; Colombia. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farina, Francesca R.. Universidad Adolfo Ibañez; Chile
Fil: Reyes, Pablo. Trinity College Dublin; Irlanda
Fil: Javandel, Shireen. University of California; Estados Unidos
Fil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Deleglise, Álvaro. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Colombia. Pontificia Universidad Javeriana; Colombia
Fil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México
Fil: Slachevsky, Andrea. Geroscience Center for Brain Health and Metabolism; Chile. Universidad de Chile; Chile. Universidad del Desarrollo; Chile
Fil: Behrens, María I.. Universidad de Chile; Chile
Fil: Possin, Katherine L.. University of California; Estados Unidos
Fil: Lawlor, Brian. University of California; Estados Unidos. Trinity College Dublin; Irlanda
Fil: Valcour, Victor. University of California; Estados Unidos
Fil: Yokoyama, Jennifer S.. University of California; Estados Unidos
Fil: Miller, Bruce. University of California; Estados Unidos
Fil: Ibañez, Agustin. University of California; Estados Unidos
Materia: Demencia
Resonancias
Vulnerabilidad
Inequidad
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/265399

Acceder

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network_name_str	CONICET Digital (CONICET)
spelling	Structural inequality linked to brain volume and network dynamics in aging and dementia across the AmericasLegaz, AgustinaAltschuler, FlorenciaGonzalez Gomez, RaulHernández, HernánBaez, SandraMigeot, JoaquínFittipaldi, María SolMedel, VicenteMaito, Marcelo AdriánGodoy, María EugeniaMoguilner, SebastiánCruzat, JosephineCoronel Oliveros, CarlosTagliazuchi, EnzoSantamaria Garcia, HernandoFarina, Francesca R.Reyes, PabloJavandel, ShireenGarcía, Adolfo MartínDeleglise, ÁlvaroMatallana, Diana L.Avila Funes, José AlbertoSlachevsky, AndreaBehrens, María I.Possin, Katherine L.Lawlor, BrianValcour, VictorYokoyama, Jennifer S.Miller, BruceIbañez, AgustinDemenciaResonanciasVulnerabilidadInequidadhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations.Fil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Altschuler, Florencia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; ArgentinaFil: Hernández, Hernán. Universidad Adolfo Ibañez; ChileFil: Baez, Sandra. Trinity College Dublin; Irlanda. Universidad de los Andes; ColombiaFil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; IrlandaFil: Fittipaldi, María Sol. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Medel, Vicente. Universidad Adolfo Ibañez; ChileFil: Maito, Marcelo Adrián. Universidad de San Andrés; ArgentinaFil: Godoy, María Eugenia. Universidad de San Andrés; ArgentinaFil: Moguilner, Sebastián. Trinity College Dublin; IrlandaFil: Cruzat, Josephine. Universidad Adolfo Ibañez; ChileFil: Coronel Oliveros, Carlos. Trinity College Dublin; IrlandaFil: Tagliazuchi, Enzo. Universidad Adolfo Ibañez; ChileFil: Santamaria Garcia, Hernando. Hospital Universitario San Ignacio; Colombia. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Farina, Francesca R.. Universidad Adolfo Ibañez; ChileFil: Reyes, Pablo. Trinity College Dublin; IrlandaFil: Javandel, Shireen. University of California; Estados UnidosFil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Deleglise, Álvaro. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Colombia. Pontificia Universidad Javeriana; ColombiaFil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; MéxicoFil: Slachevsky, Andrea. Geroscience Center for Brain Health and Metabolism; Chile. Universidad de Chile; Chile. Universidad del Desarrollo; ChileFil: Behrens, María I.. Universidad de Chile; ChileFil: Possin, Katherine L.. University of California; Estados UnidosFil: Lawlor, Brian. University of California; Estados Unidos. Trinity College Dublin; IrlandaFil: Valcour, Victor. University of California; Estados UnidosFil: Yokoyama, Jennifer S.. University of California; Estados UnidosFil: Miller, Bruce. University of California; Estados UnidosFil: Ibañez, Agustin. University of California; Estados UnidosSpringer2024-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265399Legaz, Agustina; Altschuler, Florencia; Gonzalez Gomez, Raul; Hernández, Hernán; Baez, Sandra; et al.; Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas; Springer; Nature Aging; 5; 2; 12-2024; 259-2742662-8465CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s43587-024-00781-2info:eu-repo/semantics/altIdentifier/doi/10.1038/s43587-024-00781-2info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s43587-024-00781-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:08Zoai:ri.conicet.gov.ar:11336/265399instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:08.498CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
title	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
spellingShingle	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas Legaz, Agustina Demencia Resonancias Vulnerabilidad Inequidad
title_short	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
title_full	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
title_fullStr	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
title_full_unstemmed	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
title_sort	Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas
dc.creator.none.fl_str_mv	Legaz, Agustina Altschuler, Florencia Gonzalez Gomez, Raul Hernández, Hernán Baez, Sandra Migeot, Joaquín Fittipaldi, María Sol Medel, Vicente Maito, Marcelo Adrián Godoy, María Eugenia Moguilner, Sebastián Cruzat, Josephine Coronel Oliveros, Carlos Tagliazuchi, Enzo Santamaria Garcia, Hernando Farina, Francesca R. Reyes, Pablo Javandel, Shireen García, Adolfo Martín Deleglise, Álvaro Matallana, Diana L. Avila Funes, José Alberto Slachevsky, Andrea Behrens, María I. Possin, Katherine L. Lawlor, Brian Valcour, Victor Yokoyama, Jennifer S. Miller, Bruce Ibañez, Agustin
author	Legaz, Agustina
author_facet	Legaz, Agustina Altschuler, Florencia Gonzalez Gomez, Raul Hernández, Hernán Baez, Sandra Migeot, Joaquín Fittipaldi, María Sol Medel, Vicente Maito, Marcelo Adrián Godoy, María Eugenia Moguilner, Sebastián Cruzat, Josephine Coronel Oliveros, Carlos Tagliazuchi, Enzo Santamaria Garcia, Hernando Farina, Francesca R. Reyes, Pablo Javandel, Shireen García, Adolfo Martín Deleglise, Álvaro Matallana, Diana L. Avila Funes, José Alberto Slachevsky, Andrea Behrens, María I. Possin, Katherine L. Lawlor, Brian Valcour, Victor Yokoyama, Jennifer S. Miller, Bruce Ibañez, Agustin
author_role	author
author2	Altschuler, Florencia Gonzalez Gomez, Raul Hernández, Hernán Baez, Sandra Migeot, Joaquín Fittipaldi, María Sol Medel, Vicente Maito, Marcelo Adrián Godoy, María Eugenia Moguilner, Sebastián Cruzat, Josephine Coronel Oliveros, Carlos Tagliazuchi, Enzo Santamaria Garcia, Hernando Farina, Francesca R. Reyes, Pablo Javandel, Shireen García, Adolfo Martín Deleglise, Álvaro Matallana, Diana L. Avila Funes, José Alberto Slachevsky, Andrea Behrens, María I. Possin, Katherine L. Lawlor, Brian Valcour, Victor Yokoyama, Jennifer S. Miller, Bruce Ibañez, Agustin
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Demencia Resonancias Vulnerabilidad Inequidad
topic	Demencia Resonancias Vulnerabilidad Inequidad
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations. Fil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Altschuler, Florencia. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina Fil: Hernández, Hernán. Universidad Adolfo Ibañez; Chile Fil: Baez, Sandra. Trinity College Dublin; Irlanda. Universidad de los Andes; Colombia Fil: Migeot, Joaquín. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda Fil: Fittipaldi, María Sol. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Medel, Vicente. Universidad Adolfo Ibañez; Chile Fil: Maito, Marcelo Adrián. Universidad de San Andrés; Argentina Fil: Godoy, María Eugenia. Universidad de San Andrés; Argentina Fil: Moguilner, Sebastián. Trinity College Dublin; Irlanda Fil: Cruzat, Josephine. Universidad Adolfo Ibañez; Chile Fil: Coronel Oliveros, Carlos. Trinity College Dublin; Irlanda Fil: Tagliazuchi, Enzo. Universidad Adolfo Ibañez; Chile Fil: Santamaria Garcia, Hernando. Hospital Universitario San Ignacio; Colombia. Pontificia Universidad Javeriana; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Farina, Francesca R.. Universidad Adolfo Ibañez; Chile Fil: Reyes, Pablo. Trinity College Dublin; Irlanda Fil: Javandel, Shireen. University of California; Estados Unidos Fil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Deleglise, Álvaro. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Colombia. Pontificia Universidad Javeriana; Colombia Fil: Avila Funes, José Alberto. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México Fil: Slachevsky, Andrea. Geroscience Center for Brain Health and Metabolism; Chile. Universidad de Chile; Chile. Universidad del Desarrollo; Chile Fil: Behrens, María I.. Universidad de Chile; Chile Fil: Possin, Katherine L.. University of California; Estados Unidos Fil: Lawlor, Brian. University of California; Estados Unidos. Trinity College Dublin; Irlanda Fil: Valcour, Victor. University of California; Estados Unidos Fil: Yokoyama, Jennifer S.. University of California; Estados Unidos Fil: Miller, Bruce. University of California; Estados Unidos Fil: Ibañez, Agustin. University of California; Estados Unidos
description	Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer’s disease and frontotemporal lobe degeneration from Latin America and the United States. Greater structural inequality was linked to reduced brain volume and connectivity, with stronger effects in Latin America, especially in the temporo-cerebellar, fronto-thalamic and hippocampal regions. In the United States, milder effects were observed in the insular-cingular and temporal areas. Results were more pronounced in Alzheimer’s disease and were independent of age, sex, education, cognition and other confounding factors. The findings highlight the critical role of structural inequality in aging and dementia, emphasizing the biological embedding of macrosocial factors and the need for targeted interventions in underserved populations.
publishDate	2024
dc.date.none.fl_str_mv	2024-12
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/265399 Legaz, Agustina; Altschuler, Florencia; Gonzalez Gomez, Raul; Hernández, Hernán; Baez, Sandra; et al.; Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas; Springer; Nature Aging; 5; 2; 12-2024; 259-274 2662-8465 CONICET Digital CONICET
url	http://hdl.handle.net/11336/265399
identifier_str_mv	Legaz, Agustina; Altschuler, Florencia; Gonzalez Gomez, Raul; Hernández, Hernán; Baez, Sandra; et al.; Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas; Springer; Nature Aging; 5; 2; 12-2024; 259-274 2662-8465 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
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dc.publisher.none.fl_str_mv	Springer
publisher.none.fl_str_mv	Springer
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repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas

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