Social exposome and brain health outcomes of dementia across Latin America

Autores
Migeot, Joaquin; Pina Escudero, Stefanie D.; Hernandez, Hernan; Gonzalez Gomez, Raul; Legaz, Agustina; Fittipaldi, María Sol; Resende, Elisa de Paula França; Duran Aniotz, Claudia; Avila Funes, Jose Alberto; Behrens, Maria I.; Bruno, Martin; Cardona Londoño, Juan Felipe; Custodio, Nilton; García, Adolfo Martín; Godoy, Maria E.; Hu, Kun; Lanata, Serggio; Lawlor, Brian; Lopera, Francisco; Maito, Marcelo Adrian; Matallana, Diana L.; Miller, Bruce; Jaime Miranda, J.; de Oliveira, Maira Okada; Vanneste, Sven; Valcour, Victor; Wen, Olivia; Yokoyama, Jennifer S.; Possin, Katherine L.; Ibañez, Agustin Mariano
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer’s disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.
Fil: Migeot, Joaquin. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda
Fil: Pina Escudero, Stefanie D.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas; Argentina
Fil: Hernandez, Hernan. Universidad Adolfo Ibañez; Chile
Fil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; Chile
Fil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, María Sol. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos
Fil: Resende, Elisa de Paula França. University of California; Estados Unidos. Universidade Federal de Minas Gerais; Brasil
Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile
Fil: Avila Funes, Jose Alberto. Instituto Nacional de Ciencias Médicas y Nutrición; México
Fil: Behrens, Maria I.. Universidad de Chile; Chile
Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; Colombia
Fil: Custodio, Nilton. Unit Cognitive Impairment and Dementia Prevention; Perú
Fil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Godoy, Maria E.. Universidad Adolfo Ibañez; Chile
Fil: Hu, Kun. Harvard Medical School. Department of Medicine. Massachusetts General Hospital; Estados Unidos
Fil: Lanata, Serggio. University of California; Estados Unidos
Fil: Lawlor, Brian. Trinity College Dublin; Irlanda
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Maito, Marcelo Adrian. Universidad de San Andrés; Argentina
Fil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Argentina. Hospital Universitario San Ignacio; Colombia
Fil: Miller, Bruce. University of California; Estados Unidos
Fil: Jaime Miranda, J.. University of Sydney; Australia
Fil: de Oliveira, Maira Okada. University of California; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Vanneste, Sven. Trinity College Dublin; Irlanda
Fil: Valcour, Victor. University of California; Estados Unidos
Fil: Wen, Olivia. Boston College; Estados Unidos
Fil: Yokoyama, Jennifer S.. University of California; Estados Unidos
Fil: Possin, Katherine L.. University of California; Estados Unidos
Fil: Ibañez, Agustin Mariano. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
Materia
DEMENCIAS
INEQUIDAD
EXPOSOMA
SALUD CEREBRAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274749

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spelling Social exposome and brain health outcomes of dementia across Latin AmericaMigeot, JoaquinPina Escudero, Stefanie D.Hernandez, HernanGonzalez Gomez, RaulLegaz, AgustinaFittipaldi, María SolResende, Elisa de Paula FrançaDuran Aniotz, ClaudiaAvila Funes, Jose AlbertoBehrens, Maria I.Bruno, MartinCardona Londoño, Juan FelipeCustodio, NiltonGarcía, Adolfo MartínGodoy, Maria E.Hu, KunLanata, SerggioLawlor, BrianLopera, FranciscoMaito, Marcelo AdrianMatallana, Diana L.Miller, BruceJaime Miranda, J.de Oliveira, Maira OkadaVanneste, SvenValcour, VictorWen, OliviaYokoyama, Jennifer S.Possin, Katherine L.Ibañez, Agustin MarianoDEMENCIASINEQUIDADEXPOSOMASALUD CEREBRALhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer’s disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.Fil: Migeot, Joaquin. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; IrlandaFil: Pina Escudero, Stefanie D.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas; ArgentinaFil: Hernandez, Hernan. Universidad Adolfo Ibañez; ChileFil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; ChileFil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fittipaldi, María Sol. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados UnidosFil: Resende, Elisa de Paula França. University of California; Estados Unidos. Universidade Federal de Minas Gerais; BrasilFil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; ChileFil: Avila Funes, Jose Alberto. Instituto Nacional de Ciencias Médicas y Nutrición; MéxicoFil: Behrens, Maria I.. Universidad de Chile; ChileFil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; ColombiaFil: Custodio, Nilton. Unit Cognitive Impairment and Dementia Prevention; PerúFil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Godoy, Maria E.. Universidad Adolfo Ibañez; ChileFil: Hu, Kun. Harvard Medical School. Department of Medicine. Massachusetts General Hospital; Estados UnidosFil: Lanata, Serggio. University of California; Estados UnidosFil: Lawlor, Brian. Trinity College Dublin; IrlandaFil: Lopera, Francisco. Universidad de Antioquia; ColombiaFil: Maito, Marcelo Adrian. Universidad de San Andrés; ArgentinaFil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Argentina. Hospital Universitario San Ignacio; ColombiaFil: Miller, Bruce. University of California; Estados UnidosFil: Jaime Miranda, J.. University of Sydney; AustraliaFil: de Oliveira, Maira Okada. University of California; Estados Unidos. Universidade de Sao Paulo; BrasilFil: Vanneste, Sven. Trinity College Dublin; IrlandaFil: Valcour, Victor. University of California; Estados UnidosFil: Wen, Olivia. Boston College; Estados UnidosFil: Yokoyama, Jennifer S.. University of California; Estados UnidosFil: Possin, Katherine L.. University of California; Estados UnidosFil: Ibañez, Agustin Mariano. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados UnidosNature Publishing Group2025-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274749Migeot, Joaquin; Pina Escudero, Stefanie D.; Hernandez, Hernan; Gonzalez Gomez, Raul; Legaz, Agustina; et al.; Social exposome and brain health outcomes of dementia across Latin America; Nature Publishing Group; Nature Communications; 16; 1; 9-2025; 1-182041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-025-63277-6info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-025-63277-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:56:56Zoai:ri.conicet.gov.ar:11336/274749instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:56:57.245CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Social exposome and brain health outcomes of dementia across Latin America
title Social exposome and brain health outcomes of dementia across Latin America
spellingShingle Social exposome and brain health outcomes of dementia across Latin America
Migeot, Joaquin
DEMENCIAS
INEQUIDAD
EXPOSOMA
SALUD CEREBRAL
title_short Social exposome and brain health outcomes of dementia across Latin America
title_full Social exposome and brain health outcomes of dementia across Latin America
title_fullStr Social exposome and brain health outcomes of dementia across Latin America
title_full_unstemmed Social exposome and brain health outcomes of dementia across Latin America
title_sort Social exposome and brain health outcomes of dementia across Latin America
dc.creator.none.fl_str_mv Migeot, Joaquin
Pina Escudero, Stefanie D.
Hernandez, Hernan
Gonzalez Gomez, Raul
Legaz, Agustina
Fittipaldi, María Sol
Resende, Elisa de Paula França
Duran Aniotz, Claudia
Avila Funes, Jose Alberto
Behrens, Maria I.
Bruno, Martin
Cardona Londoño, Juan Felipe
Custodio, Nilton
García, Adolfo Martín
Godoy, Maria E.
Hu, Kun
Lanata, Serggio
Lawlor, Brian
Lopera, Francisco
Maito, Marcelo Adrian
Matallana, Diana L.
Miller, Bruce
Jaime Miranda, J.
de Oliveira, Maira Okada
Vanneste, Sven
Valcour, Victor
Wen, Olivia
Yokoyama, Jennifer S.
Possin, Katherine L.
Ibañez, Agustin Mariano
author Migeot, Joaquin
author_facet Migeot, Joaquin
Pina Escudero, Stefanie D.
Hernandez, Hernan
Gonzalez Gomez, Raul
Legaz, Agustina
Fittipaldi, María Sol
Resende, Elisa de Paula França
Duran Aniotz, Claudia
Avila Funes, Jose Alberto
Behrens, Maria I.
Bruno, Martin
Cardona Londoño, Juan Felipe
Custodio, Nilton
García, Adolfo Martín
Godoy, Maria E.
Hu, Kun
Lanata, Serggio
Lawlor, Brian
Lopera, Francisco
Maito, Marcelo Adrian
Matallana, Diana L.
Miller, Bruce
Jaime Miranda, J.
de Oliveira, Maira Okada
Vanneste, Sven
Valcour, Victor
Wen, Olivia
Yokoyama, Jennifer S.
Possin, Katherine L.
Ibañez, Agustin Mariano
author_role author
author2 Pina Escudero, Stefanie D.
Hernandez, Hernan
Gonzalez Gomez, Raul
Legaz, Agustina
Fittipaldi, María Sol
Resende, Elisa de Paula França
Duran Aniotz, Claudia
Avila Funes, Jose Alberto
Behrens, Maria I.
Bruno, Martin
Cardona Londoño, Juan Felipe
Custodio, Nilton
García, Adolfo Martín
Godoy, Maria E.
Hu, Kun
Lanata, Serggio
Lawlor, Brian
Lopera, Francisco
Maito, Marcelo Adrian
Matallana, Diana L.
Miller, Bruce
Jaime Miranda, J.
de Oliveira, Maira Okada
Vanneste, Sven
Valcour, Victor
Wen, Olivia
Yokoyama, Jennifer S.
Possin, Katherine L.
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DEMENCIAS
INEQUIDAD
EXPOSOMA
SALUD CEREBRAL
topic DEMENCIAS
INEQUIDAD
EXPOSOMA
SALUD CEREBRAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer’s disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.
Fil: Migeot, Joaquin. Universidad Adolfo Ibañez; Chile. Trinity College Dublin; Irlanda
Fil: Pina Escudero, Stefanie D.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Cuyo - Sede San Juan. Facultad de Ciencias Médicas; Argentina
Fil: Hernandez, Hernan. Universidad Adolfo Ibañez; Chile
Fil: Gonzalez Gomez, Raul. Universidad Adolfo Ibañez; Chile
Fil: Legaz, Agustina. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fittipaldi, María Sol. Trinity College Dublin; Irlanda. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of California; Estados Unidos
Fil: Resende, Elisa de Paula França. University of California; Estados Unidos. Universidade Federal de Minas Gerais; Brasil
Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile
Fil: Avila Funes, Jose Alberto. Instituto Nacional de Ciencias Médicas y Nutrición; México
Fil: Behrens, Maria I.. Universidad de Chile; Chile
Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Cardona Londoño, Juan Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del Valle; Colombia
Fil: Custodio, Nilton. Unit Cognitive Impairment and Dementia Prevention; Perú
Fil: García, Adolfo Martín. Universidad de Santiago de Chile; Chile. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Godoy, Maria E.. Universidad Adolfo Ibañez; Chile
Fil: Hu, Kun. Harvard Medical School. Department of Medicine. Massachusetts General Hospital; Estados Unidos
Fil: Lanata, Serggio. University of California; Estados Unidos
Fil: Lawlor, Brian. Trinity College Dublin; Irlanda
Fil: Lopera, Francisco. Universidad de Antioquia; Colombia
Fil: Maito, Marcelo Adrian. Universidad de San Andrés; Argentina
Fil: Matallana, Diana L.. Hospital Universitario Fundación Santa Fe; Argentina. Hospital Universitario San Ignacio; Colombia
Fil: Miller, Bruce. University of California; Estados Unidos
Fil: Jaime Miranda, J.. University of Sydney; Australia
Fil: de Oliveira, Maira Okada. University of California; Estados Unidos. Universidade de Sao Paulo; Brasil
Fil: Vanneste, Sven. Trinity College Dublin; Irlanda
Fil: Valcour, Victor. University of California; Estados Unidos
Fil: Wen, Olivia. Boston College; Estados Unidos
Fil: Yokoyama, Jennifer S.. University of California; Estados Unidos
Fil: Possin, Katherine L.. University of California; Estados Unidos
Fil: Ibañez, Agustin Mariano. Universidad Adolfo Ibañez; Chile. Universidad de San Andrés; Argentina. Trinity College Dublin; Irlanda. University of California; Estados Unidos
description A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer’s disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.
publishDate 2025
dc.date.none.fl_str_mv 2025-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274749
Migeot, Joaquin; Pina Escudero, Stefanie D.; Hernandez, Hernan; Gonzalez Gomez, Raul; Legaz, Agustina; et al.; Social exposome and brain health outcomes of dementia across Latin America; Nature Publishing Group; Nature Communications; 16; 1; 9-2025; 1-18
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274749
identifier_str_mv Migeot, Joaquin; Pina Escudero, Stefanie D.; Hernandez, Hernan; Gonzalez Gomez, Raul; Legaz, Agustina; et al.; Social exposome and brain health outcomes of dementia across Latin America; Nature Publishing Group; Nature Communications; 16; 1; 9-2025; 1-18
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-025-63277-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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