The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease

Autores
Maiorana, Facundo; Neschuk, Magali; Caronia, María Virginia; Elizondo, Karina; Robledo, María Laura; Schneider, Adolfo; Veron, Georgina; Zapata, Pedro Dario; Barreyro, Fernando Javier
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Recent studies have suggested an association between H. pylori and metabolic-disfunction associated fatty liver disease (MASLD). However, epidemiologic studies have yielded inconsistent results. We aim to evaluate the association of H. pylori and G-allele PNPLA3 in MASLD diagnosis, and markers of severity.Methods: A multi-center cross-sectional study was conducted. A total 224 functional dyspepsia (FD) patients cohort who underwent gastroscopy was selected. Biochemical, clinical parameters, ultrasound, FIB-4 score, LSM by VCTE, gastric biopsies, H. pylori status, and rs738409 PNPLA3 were evaluated. A second retrospective cohort of 86 patients with biopsy-proven MASLD who underwent gastroscopy with gastric biopsies was analyzed.Results: In the FD cohort MASLD was observed in 52%, and H. pylori-positive in 51%. H. pylori infection was associated with MASLD prevalence, but in multivariate analyses adjusted for G-allele PNPLA3, it became not significant. Then in MASLD-only dyspeptic cohort, H. pylori infection was significantly linked to elevated serum AST levels and increased liver stiffness measurements, suggesting a potential role in liver injury and fibrosis. Histopathological analysis in biopsy-proven MASLD patients further supported these findings, showing a significant association between H. pylori infection and increased NAS score, fibrosis stage, and prevalence of MASH. Notably, the combination of H. pylori infection and G-allele PNPLA3 appeared to exacerbate MASLD severity beyond individual effects.Conclusions: Our results suggest that H. pylori infection may play a role in the progression of liver injury and fibrosis in patients with MASLD, especially in those with specific genetic predispositions.
Fil: Maiorana, Facundo. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Neschuk, Magali. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Caronia, María Virginia. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Elizondo, Karina. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Robledo, María Laura. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Servicio de Patología; Argentina
Fil: Schneider, Adolfo. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Veron, Georgina. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Barreyro, Fernando Javier. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Materia
Helicobacter pylori
PNPLA3
metabolic-disfunction associated fatty liver disease
liver fibrosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/245799

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver diseaseMaiorana, FacundoNeschuk, MagaliCaronia, María VirginiaElizondo, KarinaRobledo, María LauraSchneider, AdolfoVeron, GeorginaZapata, Pedro DarioBarreyro, Fernando JavierHelicobacter pyloriPNPLA3metabolic-disfunction associated fatty liver diseaseliver fibrosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Recent studies have suggested an association between H. pylori and metabolic-disfunction associated fatty liver disease (MASLD). However, epidemiologic studies have yielded inconsistent results. We aim to evaluate the association of H. pylori and G-allele PNPLA3 in MASLD diagnosis, and markers of severity.Methods: A multi-center cross-sectional study was conducted. A total 224 functional dyspepsia (FD) patients cohort who underwent gastroscopy was selected. Biochemical, clinical parameters, ultrasound, FIB-4 score, LSM by VCTE, gastric biopsies, H. pylori status, and rs738409 PNPLA3 were evaluated. A second retrospective cohort of 86 patients with biopsy-proven MASLD who underwent gastroscopy with gastric biopsies was analyzed.Results: In the FD cohort MASLD was observed in 52%, and H. pylori-positive in 51%. H. pylori infection was associated with MASLD prevalence, but in multivariate analyses adjusted for G-allele PNPLA3, it became not significant. Then in MASLD-only dyspeptic cohort, H. pylori infection was significantly linked to elevated serum AST levels and increased liver stiffness measurements, suggesting a potential role in liver injury and fibrosis. Histopathological analysis in biopsy-proven MASLD patients further supported these findings, showing a significant association between H. pylori infection and increased NAS score, fibrosis stage, and prevalence of MASH. Notably, the combination of H. pylori infection and G-allele PNPLA3 appeared to exacerbate MASLD severity beyond individual effects.Conclusions: Our results suggest that H. pylori infection may play a role in the progression of liver injury and fibrosis in patients with MASLD, especially in those with specific genetic predispositions.Fil: Maiorana, Facundo. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; ArgentinaFil: Neschuk, Magali. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; ArgentinaFil: Caronia, María Virginia. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; ArgentinaFil: Elizondo, Karina. Instituto Universidad de la Fundación "Héctor Barceló"; ArgentinaFil: Robledo, María Laura. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Servicio de Patología; ArgentinaFil: Schneider, Adolfo. Instituto Universidad de la Fundación "Héctor Barceló"; ArgentinaFil: Veron, Georgina. Instituto Universidad de la Fundación "Héctor Barceló"; ArgentinaFil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; ArgentinaFil: Barreyro, Fernando Javier. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaPublic Library of Science2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245799Maiorana, Facundo; Neschuk, Magali; Caronia, María Virginia; Elizondo, Karina; Robledo, María Laura; et al.; The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease; Public Library of Science; Plos One; 19; 9; 9-2024; 1-201932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pone.0310361info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0310361info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:23Zoai:ri.conicet.gov.ar:11336/245799instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:24.134CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
title The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
spellingShingle The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
Maiorana, Facundo
Helicobacter pylori
PNPLA3
metabolic-disfunction associated fatty liver disease
liver fibrosis
title_short The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
title_full The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
title_fullStr The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
title_full_unstemmed The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
title_sort The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease
dc.creator.none.fl_str_mv Maiorana, Facundo
Neschuk, Magali
Caronia, María Virginia
Elizondo, Karina
Robledo, María Laura
Schneider, Adolfo
Veron, Georgina
Zapata, Pedro Dario
Barreyro, Fernando Javier
author Maiorana, Facundo
author_facet Maiorana, Facundo
Neschuk, Magali
Caronia, María Virginia
Elizondo, Karina
Robledo, María Laura
Schneider, Adolfo
Veron, Georgina
Zapata, Pedro Dario
Barreyro, Fernando Javier
author_role author
author2 Neschuk, Magali
Caronia, María Virginia
Elizondo, Karina
Robledo, María Laura
Schneider, Adolfo
Veron, Georgina
Zapata, Pedro Dario
Barreyro, Fernando Javier
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Helicobacter pylori
PNPLA3
metabolic-disfunction associated fatty liver disease
liver fibrosis
topic Helicobacter pylori
PNPLA3
metabolic-disfunction associated fatty liver disease
liver fibrosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Recent studies have suggested an association between H. pylori and metabolic-disfunction associated fatty liver disease (MASLD). However, epidemiologic studies have yielded inconsistent results. We aim to evaluate the association of H. pylori and G-allele PNPLA3 in MASLD diagnosis, and markers of severity.Methods: A multi-center cross-sectional study was conducted. A total 224 functional dyspepsia (FD) patients cohort who underwent gastroscopy was selected. Biochemical, clinical parameters, ultrasound, FIB-4 score, LSM by VCTE, gastric biopsies, H. pylori status, and rs738409 PNPLA3 were evaluated. A second retrospective cohort of 86 patients with biopsy-proven MASLD who underwent gastroscopy with gastric biopsies was analyzed.Results: In the FD cohort MASLD was observed in 52%, and H. pylori-positive in 51%. H. pylori infection was associated with MASLD prevalence, but in multivariate analyses adjusted for G-allele PNPLA3, it became not significant. Then in MASLD-only dyspeptic cohort, H. pylori infection was significantly linked to elevated serum AST levels and increased liver stiffness measurements, suggesting a potential role in liver injury and fibrosis. Histopathological analysis in biopsy-proven MASLD patients further supported these findings, showing a significant association between H. pylori infection and increased NAS score, fibrosis stage, and prevalence of MASH. Notably, the combination of H. pylori infection and G-allele PNPLA3 appeared to exacerbate MASLD severity beyond individual effects.Conclusions: Our results suggest that H. pylori infection may play a role in the progression of liver injury and fibrosis in patients with MASLD, especially in those with specific genetic predispositions.
Fil: Maiorana, Facundo. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Neschuk, Magali. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Caronia, María Virginia. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Elizondo, Karina. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Robledo, María Laura. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan". Servicio de Patología; Argentina
Fil: Schneider, Adolfo. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Veron, Georgina. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
Fil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina
Fil: Barreyro, Fernando Javier. Universidad Nacional de Misiones. Facultad de Cs.exactas Químicas y Naturales. Departamento de Bioquímica Clinica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
description Background: Recent studies have suggested an association between H. pylori and metabolic-disfunction associated fatty liver disease (MASLD). However, epidemiologic studies have yielded inconsistent results. We aim to evaluate the association of H. pylori and G-allele PNPLA3 in MASLD diagnosis, and markers of severity.Methods: A multi-center cross-sectional study was conducted. A total 224 functional dyspepsia (FD) patients cohort who underwent gastroscopy was selected. Biochemical, clinical parameters, ultrasound, FIB-4 score, LSM by VCTE, gastric biopsies, H. pylori status, and rs738409 PNPLA3 were evaluated. A second retrospective cohort of 86 patients with biopsy-proven MASLD who underwent gastroscopy with gastric biopsies was analyzed.Results: In the FD cohort MASLD was observed in 52%, and H. pylori-positive in 51%. H. pylori infection was associated with MASLD prevalence, but in multivariate analyses adjusted for G-allele PNPLA3, it became not significant. Then in MASLD-only dyspeptic cohort, H. pylori infection was significantly linked to elevated serum AST levels and increased liver stiffness measurements, suggesting a potential role in liver injury and fibrosis. Histopathological analysis in biopsy-proven MASLD patients further supported these findings, showing a significant association between H. pylori infection and increased NAS score, fibrosis stage, and prevalence of MASH. Notably, the combination of H. pylori infection and G-allele PNPLA3 appeared to exacerbate MASLD severity beyond individual effects.Conclusions: Our results suggest that H. pylori infection may play a role in the progression of liver injury and fibrosis in patients with MASLD, especially in those with specific genetic predispositions.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245799
Maiorana, Facundo; Neschuk, Magali; Caronia, María Virginia; Elizondo, Karina; Robledo, María Laura; et al.; The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease; Public Library of Science; Plos One; 19; 9; 9-2024; 1-20
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245799
identifier_str_mv Maiorana, Facundo; Neschuk, Magali; Caronia, María Virginia; Elizondo, Karina; Robledo, María Laura; et al.; The interplay between Helicobacter pylori infection and rs738409 PNPLA3 in metabolic dysfunction-associated steatotic liver disease; Public Library of Science; Plos One; 19; 9; 9-2024; 1-20
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0310361
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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