Covid-19 in children- An envolving picture

Autores
Arruvito, Maria Lourdes
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Among the most intriguing observations in Coronavirus disease 2019 (COVID-19) is the reduced incidence and mortality in children. In fact, and in contrast to other viral respiratory infections such as those caused by influenza and respiratory syncytial virus, SARS-CoV-2 infection usually develop a mild course in children. The reasons for this remain unclear. Considering that pulmonary infiltration by neutrophils plays a relevant role in the development of severe COVID-19 in adults, we analyzed whether neutrophils in children infected with SARS-CoV-2 expressed a particular phenotypic profile. We found that neutrophils from children with COVID-19 express a distinct signature characterized by a reduced expression of adhesion molecules involved in neutrophil migration together with an increased expression of both, the inflammatory markers CD64, HLA-DR and PECAM-1 and the inhibitory receptors leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and programmed death-ligand 1 (PD-L1). This finding is unusual as neutrophil activation is associated with the up-regulation of adhesion molecules as it was observed in adult COVID-19. We hypothesized that this particular signature might prevent neutrophil infiltration in the pulmonary capillaries thus providing protection against tissue injury in the children.While the course of SARS-CoV-2 infection in children is usually mild, some children develop severe COVID-19. It has been shown that severe disease in adults is associated with a delayed kinetic of antibody production. We also studied whether a defective antibody response could be associated with a more severe condition in children. We found that children with severe COVID-19 display a very poor and late antibody response against SARS-CoV-2. This weak antibody response was associated with a low frequency of circulating Follicular Helper T cells and a systemic inflammatory response revealed by high levels of inflammatory cytokines in plasma. Vaccines against COVID-19 have shown very high levels of safety and effectiveness. In countries that have led vaccination globally, such as Israel and the United Kingdom, the pandemic seems to hold first in the infection of children. In this scenario, it is urgent to characterize the factors determining the predisposition of some children to suffer severe COVID-19.
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental
Asociación Argentina de Nanomedicina
Materia
COVID-19
Pediatria
Respuesta inmune
vacunas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/153521

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spelling Covid-19 in children- An envolving pictureArruvito, Maria LourdesCOVID-19PediatriaRespuesta inmunevacunashttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Among the most intriguing observations in Coronavirus disease 2019 (COVID-19) is the reduced incidence and mortality in children. In fact, and in contrast to other viral respiratory infections such as those caused by influenza and respiratory syncytial virus, SARS-CoV-2 infection usually develop a mild course in children. The reasons for this remain unclear. Considering that pulmonary infiltration by neutrophils plays a relevant role in the development of severe COVID-19 in adults, we analyzed whether neutrophils in children infected with SARS-CoV-2 expressed a particular phenotypic profile. We found that neutrophils from children with COVID-19 express a distinct signature characterized by a reduced expression of adhesion molecules involved in neutrophil migration together with an increased expression of both, the inflammatory markers CD64, HLA-DR and PECAM-1 and the inhibitory receptors leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and programmed death-ligand 1 (PD-L1). This finding is unusual as neutrophil activation is associated with the up-regulation of adhesion molecules as it was observed in adult COVID-19. We hypothesized that this particular signature might prevent neutrophil infiltration in the pulmonary capillaries thus providing protection against tissue injury in the children.While the course of SARS-CoV-2 infection in children is usually mild, some children develop severe COVID-19. It has been shown that severe disease in adults is associated with a delayed kinetic of antibody production. We also studied whether a defective antibody response could be associated with a more severe condition in children. We found that children with severe COVID-19 display a very poor and late antibody response against SARS-CoV-2. This weak antibody response was associated with a low frequency of circulating Follicular Helper T cells and a systemic inflammatory response revealed by high levels of inflammatory cytokines in plasma. Vaccines against COVID-19 have shown very high levels of safety and effectiveness. In countries that have led vaccination globally, such as Israel and the United Kingdom, the pandemic seems to hold first in the infection of children. In this scenario, it is urgent to characterize the factors determining the predisposition of some children to suffer severe COVID-19.Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaAnnual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)ArgentinaSociedad Argentina de Investigación ClínicaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología ExperimentalAsociación Argentina de NanomedicinaFundación Revista MedicinaCurino, Alejandro CarlosMaccioni, MarianaSchaiquevich, Paula SusanaDuran, Hebe Alicia2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/153521Covid-19 in children- An envolving picture; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Argentina; 2021; 1-21669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.reunionbiociencias.com.ar/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:29:44Zoai:ri.conicet.gov.ar:11336/153521instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:29:45.212CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Covid-19 in children- An envolving picture
title Covid-19 in children- An envolving picture
spellingShingle Covid-19 in children- An envolving picture
Arruvito, Maria Lourdes
COVID-19
Pediatria
Respuesta inmune
vacunas
title_short Covid-19 in children- An envolving picture
title_full Covid-19 in children- An envolving picture
title_fullStr Covid-19 in children- An envolving picture
title_full_unstemmed Covid-19 in children- An envolving picture
title_sort Covid-19 in children- An envolving picture
dc.creator.none.fl_str_mv Arruvito, Maria Lourdes
author Arruvito, Maria Lourdes
author_facet Arruvito, Maria Lourdes
author_role author
dc.contributor.none.fl_str_mv Curino, Alejandro Carlos
Maccioni, Mariana
Schaiquevich, Paula Susana
Duran, Hebe Alicia
dc.subject.none.fl_str_mv COVID-19
Pediatria
Respuesta inmune
vacunas
topic COVID-19
Pediatria
Respuesta inmune
vacunas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Among the most intriguing observations in Coronavirus disease 2019 (COVID-19) is the reduced incidence and mortality in children. In fact, and in contrast to other viral respiratory infections such as those caused by influenza and respiratory syncytial virus, SARS-CoV-2 infection usually develop a mild course in children. The reasons for this remain unclear. Considering that pulmonary infiltration by neutrophils plays a relevant role in the development of severe COVID-19 in adults, we analyzed whether neutrophils in children infected with SARS-CoV-2 expressed a particular phenotypic profile. We found that neutrophils from children with COVID-19 express a distinct signature characterized by a reduced expression of adhesion molecules involved in neutrophil migration together with an increased expression of both, the inflammatory markers CD64, HLA-DR and PECAM-1 and the inhibitory receptors leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and programmed death-ligand 1 (PD-L1). This finding is unusual as neutrophil activation is associated with the up-regulation of adhesion molecules as it was observed in adult COVID-19. We hypothesized that this particular signature might prevent neutrophil infiltration in the pulmonary capillaries thus providing protection against tissue injury in the children.While the course of SARS-CoV-2 infection in children is usually mild, some children develop severe COVID-19. It has been shown that severe disease in adults is associated with a delayed kinetic of antibody production. We also studied whether a defective antibody response could be associated with a more severe condition in children. We found that children with severe COVID-19 display a very poor and late antibody response against SARS-CoV-2. This weak antibody response was associated with a low frequency of circulating Follicular Helper T cells and a systemic inflammatory response revealed by high levels of inflammatory cytokines in plasma. Vaccines against COVID-19 have shown very high levels of safety and effectiveness. In countries that have led vaccination globally, such as Israel and the United Kingdom, the pandemic seems to hold first in the infection of children. In this scenario, it is urgent to characterize the factors determining the predisposition of some children to suffer severe COVID-19.
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar)
Argentina
Sociedad Argentina de Investigación Clínica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental
Asociación Argentina de Nanomedicina
description Among the most intriguing observations in Coronavirus disease 2019 (COVID-19) is the reduced incidence and mortality in children. In fact, and in contrast to other viral respiratory infections such as those caused by influenza and respiratory syncytial virus, SARS-CoV-2 infection usually develop a mild course in children. The reasons for this remain unclear. Considering that pulmonary infiltration by neutrophils plays a relevant role in the development of severe COVID-19 in adults, we analyzed whether neutrophils in children infected with SARS-CoV-2 expressed a particular phenotypic profile. We found that neutrophils from children with COVID-19 express a distinct signature characterized by a reduced expression of adhesion molecules involved in neutrophil migration together with an increased expression of both, the inflammatory markers CD64, HLA-DR and PECAM-1 and the inhibitory receptors leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) and programmed death-ligand 1 (PD-L1). This finding is unusual as neutrophil activation is associated with the up-regulation of adhesion molecules as it was observed in adult COVID-19. We hypothesized that this particular signature might prevent neutrophil infiltration in the pulmonary capillaries thus providing protection against tissue injury in the children.While the course of SARS-CoV-2 infection in children is usually mild, some children develop severe COVID-19. It has been shown that severe disease in adults is associated with a delayed kinetic of antibody production. We also studied whether a defective antibody response could be associated with a more severe condition in children. We found that children with severe COVID-19 display a very poor and late antibody response against SARS-CoV-2. This weak antibody response was associated with a low frequency of circulating Follicular Helper T cells and a systemic inflammatory response revealed by high levels of inflammatory cytokines in plasma. Vaccines against COVID-19 have shown very high levels of safety and effectiveness. In countries that have led vaccination globally, such as Israel and the United Kingdom, the pandemic seems to hold first in the infection of children. In this scenario, it is urgent to characterize the factors determining the predisposition of some children to suffer severe COVID-19.
publishDate 2021
dc.date.none.fl_str_mv 2021
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info:eu-repo/semantics/conferenceObject
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/153521
Covid-19 in children- An envolving picture; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Argentina; 2021; 1-2
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/153521
identifier_str_mv Covid-19 in children- An envolving picture; Annual Meeting of Bioscience Societies 2021: LXVI Annual Meeting of Sociedad Argentina de Investigación Clínica (SAIC), LXIX Annual Meeting of Sociedad Argentina de Inmunología(SAI), LIII Annual Meeting of Asociación Argentina de Farmacología Experimental (AAFE), XI Annual Meeting of Asociación Argentina de Nanomedicinas (NANOMED-Ar); Argentina; 2021; 1-2
1669-9106
CONICET Digital
CONICET
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language eng
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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