Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride

Autores
Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, Lucía; Fernandez, Carlos; Orgueira, Hernán; Comin, Maria Julieta
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together with debutyldronedarone were detected by LC?MS analysis during process development. A successful synthetic strategy for the synthesis of these potential impurities was developed facilitating the access to new impurity reference standards. Their synthesis and characterization are discussed in detail. The availability of these impurity standards allowed cost reduction through the increase of process control.
Fil: Santos, Marina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Lia Cynthia. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina
Fil: Checura, Cintia Carolina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina
Fil: Gandolfi Donadío, Lucía. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernandez, Carlos. MAPRIMED; Argentina
Fil: Orgueira, Hernán. MAPRIMED; Argentina
Fil: Comin, Maria Julieta. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Dronedarone Hydrochloride
Antiarrhythmic Drug
Related Substances
Synthesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42260
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochlorideSantos, MarinaGarcia, Lia CynthiaChecura, Cintia CarolinaGandolfi Donadío, LucíaFernandez, CarlosOrgueira, HernánComin, Maria JulietaDronedarone HydrochlorideAntiarrhythmic DrugRelated SubstancesSynthesishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together with debutyldronedarone were detected by LC?MS analysis during process development. A successful synthetic strategy for the synthesis of these potential impurities was developed facilitating the access to new impurity reference standards. Their synthesis and characterization are discussed in detail. The availability of these impurity standards allowed cost reduction through the increase of process control.Fil: Santos, Marina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Lia Cynthia. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; ArgentinaFil: Checura, Cintia Carolina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; ArgentinaFil: Gandolfi Donadío, Lucía. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernandez, Carlos. MAPRIMED; ArgentinaFil: Orgueira, Hernán. MAPRIMED; ArgentinaFil: Comin, Maria Julieta. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42260Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, Lucía; Fernandez, Carlos; et al.; Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 114; 10-2015; 441-4460731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2015.06.026info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0731708515300418info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:37Zoai:ri.conicet.gov.ar:11336/42260instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:37.374CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
title Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
spellingShingle Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
Santos, Marina
Dronedarone Hydrochloride
Antiarrhythmic Drug
Related Substances
Synthesis
title_short Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
title_full Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
title_fullStr Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
title_full_unstemmed Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
title_sort Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride
dc.creator.none.fl_str_mv Santos, Marina
Garcia, Lia Cynthia
Checura, Cintia Carolina
Gandolfi Donadío, Lucía
Fernandez, Carlos
Orgueira, Hernán
Comin, Maria Julieta
author Santos, Marina
author_facet Santos, Marina
Garcia, Lia Cynthia
Checura, Cintia Carolina
Gandolfi Donadío, Lucía
Fernandez, Carlos
Orgueira, Hernán
Comin, Maria Julieta
author_role author
author2 Garcia, Lia Cynthia
Checura, Cintia Carolina
Gandolfi Donadío, Lucía
Fernandez, Carlos
Orgueira, Hernán
Comin, Maria Julieta
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dronedarone Hydrochloride
Antiarrhythmic Drug
Related Substances
Synthesis
topic Dronedarone Hydrochloride
Antiarrhythmic Drug
Related Substances
Synthesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together with debutyldronedarone were detected by LC?MS analysis during process development. A successful synthetic strategy for the synthesis of these potential impurities was developed facilitating the access to new impurity reference standards. Their synthesis and characterization are discussed in detail. The availability of these impurity standards allowed cost reduction through the increase of process control.
Fil: Santos, Marina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Lia Cynthia. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina
Fil: Checura, Cintia Carolina. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina
Fil: Gandolfi Donadío, Lucía. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernandez, Carlos. MAPRIMED; Argentina
Fil: Orgueira, Hernán. MAPRIMED; Argentina
Fil: Comin, Maria Julieta. Instituto Nacional de Tecnología Industrial. Centro de Investigación y Desarrollo En Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Two new potential impurities of antiarrhythmic drug substance Dronedarone Hydrochloride together with debutyldronedarone were detected by LC?MS analysis during process development. A successful synthetic strategy for the synthesis of these potential impurities was developed facilitating the access to new impurity reference standards. Their synthesis and characterization are discussed in detail. The availability of these impurity standards allowed cost reduction through the increase of process control.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42260
Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, Lucía; Fernandez, Carlos; et al.; Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 114; 10-2015; 441-446
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42260
identifier_str_mv Santos, Marina; Garcia, Lia Cynthia; Checura, Cintia Carolina; Gandolfi Donadío, Lucía; Fernandez, Carlos; et al.; Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 114; 10-2015; 441-446
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2015.06.026
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0731708515300418
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781699437887488
score 12.928904

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