The trophoblast clock controls transport across placenta in mice
- Autores
- Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; Oster, Henrik; Astiz, Mariana
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.
Fil: Demarez, Cécile. Universität Zu Lübeck; Alemania
Fil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; Alemania
Fil: Krohn, Markus. Universität Zu Lübeck; Alemania
Fil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Schwaninger, Markus. Universität Zu Lübeck; Alemania
Fil: Oster, Henrik. Universität Zu Lübeck; Alemania
Fil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
CIRCADIAN CLOCK
MICE
PLACENTA
TROPHOBLAST
XENOBIOTIC EFFLUX TRANSPORTER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/175315
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The trophoblast clock controls transport across placenta in miceDemarez, Cécilede Assis, Leonardo Vinicius MonteiroKrohn, MarkusRamella, NahuelSchwaninger, MarkusOster, HenrikAstiz, MarianaCIRCADIAN CLOCKMICEPLACENTATROPHOBLASTXENOBIOTIC EFFLUX TRANSPORTERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.Fil: Demarez, Cécile. Universität Zu Lübeck; AlemaniaFil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; AlemaniaFil: Krohn, Markus. Universität Zu Lübeck; AlemaniaFil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Schwaninger, Markus. Universität Zu Lübeck; AlemaniaFil: Oster, Henrik. Universität Zu Lübeck; AlemaniaFil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaCompany of Biologists2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175315Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-110950-1991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1242/dev.197673info:eu-repo/semantics/altIdentifier/url/https://journals.biologists.com/dev/article/148/8/dev197673/256558/The-trophoblast-clock-controls-transport-acrossinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:31Zoai:ri.conicet.gov.ar:11336/175315instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:31.78CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The trophoblast clock controls transport across placenta in mice |
title |
The trophoblast clock controls transport across placenta in mice |
spellingShingle |
The trophoblast clock controls transport across placenta in mice Demarez, Cécile CIRCADIAN CLOCK MICE PLACENTA TROPHOBLAST XENOBIOTIC EFFLUX TRANSPORTER |
title_short |
The trophoblast clock controls transport across placenta in mice |
title_full |
The trophoblast clock controls transport across placenta in mice |
title_fullStr |
The trophoblast clock controls transport across placenta in mice |
title_full_unstemmed |
The trophoblast clock controls transport across placenta in mice |
title_sort |
The trophoblast clock controls transport across placenta in mice |
dc.creator.none.fl_str_mv |
Demarez, Cécile de Assis, Leonardo Vinicius Monteiro Krohn, Markus Ramella, Nahuel Schwaninger, Markus Oster, Henrik Astiz, Mariana |
author |
Demarez, Cécile |
author_facet |
Demarez, Cécile de Assis, Leonardo Vinicius Monteiro Krohn, Markus Ramella, Nahuel Schwaninger, Markus Oster, Henrik Astiz, Mariana |
author_role |
author |
author2 |
de Assis, Leonardo Vinicius Monteiro Krohn, Markus Ramella, Nahuel Schwaninger, Markus Oster, Henrik Astiz, Mariana |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
CIRCADIAN CLOCK MICE PLACENTA TROPHOBLAST XENOBIOTIC EFFLUX TRANSPORTER |
topic |
CIRCADIAN CLOCK MICE PLACENTA TROPHOBLAST XENOBIOTIC EFFLUX TRANSPORTER |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother. Fil: Demarez, Cécile. Universität Zu Lübeck; Alemania Fil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; Alemania Fil: Krohn, Markus. Universität Zu Lübeck; Alemania Fil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina Fil: Schwaninger, Markus. Universität Zu Lübeck; Alemania Fil: Oster, Henrik. Universität Zu Lübeck; Alemania Fil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/175315 Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-11 0950-1991 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/175315 |
identifier_str_mv |
Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-11 0950-1991 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.197673 info:eu-repo/semantics/altIdentifier/url/https://journals.biologists.com/dev/article/148/8/dev197673/256558/The-trophoblast-clock-controls-transport-across |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Company of Biologists |
publisher.none.fl_str_mv |
Company of Biologists |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |