The trophoblast clock controls transport across placenta in mice

Autores
Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; Oster, Henrik; Astiz, Mariana
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.
Fil: Demarez, Cécile. Universität Zu Lübeck; Alemania
Fil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; Alemania
Fil: Krohn, Markus. Universität Zu Lübeck; Alemania
Fil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Schwaninger, Markus. Universität Zu Lübeck; Alemania
Fil: Oster, Henrik. Universität Zu Lübeck; Alemania
Fil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CIRCADIAN CLOCK
MICE
PLACENTA
TROPHOBLAST
XENOBIOTIC EFFLUX TRANSPORTER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/175315
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The trophoblast clock controls transport across placenta in miceDemarez, Cécilede Assis, Leonardo Vinicius MonteiroKrohn, MarkusRamella, NahuelSchwaninger, MarkusOster, HenrikAstiz, MarianaCIRCADIAN CLOCKMICEPLACENTATROPHOBLASTXENOBIOTIC EFFLUX TRANSPORTERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.Fil: Demarez, Cécile. Universität Zu Lübeck; AlemaniaFil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; AlemaniaFil: Krohn, Markus. Universität Zu Lübeck; AlemaniaFil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Schwaninger, Markus. Universität Zu Lübeck; AlemaniaFil: Oster, Henrik. Universität Zu Lübeck; AlemaniaFil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaCompany of Biologists2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175315Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-110950-1991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1242/dev.197673info:eu-repo/semantics/altIdentifier/url/https://journals.biologists.com/dev/article/148/8/dev197673/256558/The-trophoblast-clock-controls-transport-acrossinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:07:53Zoai:ri.conicet.gov.ar:11336/175315instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:07:53.562CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The trophoblast clock controls transport across placenta in mice
title The trophoblast clock controls transport across placenta in mice
spellingShingle The trophoblast clock controls transport across placenta in mice
Demarez, Cécile
CIRCADIAN CLOCK
MICE
PLACENTA
TROPHOBLAST
XENOBIOTIC EFFLUX TRANSPORTER
title_short The trophoblast clock controls transport across placenta in mice
title_full The trophoblast clock controls transport across placenta in mice
title_fullStr The trophoblast clock controls transport across placenta in mice
title_full_unstemmed The trophoblast clock controls transport across placenta in mice
title_sort The trophoblast clock controls transport across placenta in mice
dc.creator.none.fl_str_mv Demarez, Cécile
de Assis, Leonardo Vinicius Monteiro
Krohn, Markus
Ramella, Nahuel
Schwaninger, Markus
Oster, Henrik
Astiz, Mariana
author Demarez, Cécile
author_facet Demarez, Cécile
de Assis, Leonardo Vinicius Monteiro
Krohn, Markus
Ramella, Nahuel
Schwaninger, Markus
Oster, Henrik
Astiz, Mariana
author_role author
author2 de Assis, Leonardo Vinicius Monteiro
Krohn, Markus
Ramella, Nahuel
Schwaninger, Markus
Oster, Henrik
Astiz, Mariana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CIRCADIAN CLOCK
MICE
PLACENTA
TROPHOBLAST
XENOBIOTIC EFFLUX TRANSPORTER
topic CIRCADIAN CLOCK
MICE
PLACENTA
TROPHOBLAST
XENOBIOTIC EFFLUX TRANSPORTER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.
Fil: Demarez, Cécile. Universität Zu Lübeck; Alemania
Fil: de Assis, Leonardo Vinicius Monteiro. Universität Zu Lübeck; Alemania
Fil: Krohn, Markus. Universität Zu Lübeck; Alemania
Fil: Ramella, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Fil: Schwaninger, Markus. Universität Zu Lübeck; Alemania
Fil: Oster, Henrik. Universität Zu Lübeck; Alemania
Fil: Astiz, Mariana. Universität Zu Lübeck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In mammals, 24-h rhythms of physiology and behavior are organized by a body-wide network of clock genes and proteins. Despite the well-known function of the adult circadian system, the roles of maternal, fetal and placental clocks during pregnancy are poorly defined. In the mature mouse placenta, the labyrinth zone (LZ) is of fetal origin and key for selective nutrient and waste exchange. Recently, clock gene expression has been detected in LZ and other fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity of the xenobiotic efflux pump, ATP-binding cassette sub-family B member 1 (ABCB1), likely gating the fetal exposure to drugs from the maternal circulation to certain times of the day. As more than 300 endogenous and exogenous compounds are substrates of ABCB1, our results might have implications in choosing the maternal treatment time when aiming either maximal/minimal drug availability to the fetus/mother.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/175315
Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-11
0950-1991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/175315
identifier_str_mv Demarez, Cécile; de Assis, Leonardo Vinicius Monteiro; Krohn, Markus; Ramella, Nahuel; Schwaninger, Markus; et al.; The trophoblast clock controls transport across placenta in mice; Company of Biologists; Development; 148; 8; 4-2021; 1-11
0950-1991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1242/dev.197673
info:eu-repo/semantics/altIdentifier/url/https://journals.biologists.com/dev/article/148/8/dev197673/256558/The-trophoblast-clock-controls-transport-across
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782446197014528
score 12.982451

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