CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery

Autores
Frolov, S. V.; Sindeev, S. V.; Kirschke, J. S.; Arnold, P.; Prothmann, S.; Liepsch, D.; Balasso, A.; Potlov, A.; Larrabide, Ignacio; Kaczmarz, S.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract: Flow changes after flow diverter (FD) placement may be assessed by 4D phase-contrast MR-angiography (4D flow MRI) or simulated by computational fluid dynamics (CFD). However, cross-validation and future assessments with both approaches to take advantage of their individual strengths are required. In this study, we investigate the influence of a FD on intra-aneurysmal blood flow using both MRI experiments and CFD simulations. MR measurements were performed in a true-to-scale silicone model of a wide-neck saccular aneurysm of the distal internal carotid artery before and after FD deployment. An experimental setup, including a computer-controlled piston pump, was assembled to simulate pulsatile blood flow. For CFD studies, a virtual stenting technique was used to place a FD into the aneurysm model. Boundary conditions were applied according to MRI-measured flow data. A qualitative and quantitative agreement of velocity fields measured by CFD and MRI both before and after FD placement was demonstrated. The intra-aneurysmal flow reduction in the CFD results was 19%, while a reduction of 23% was measured by 4D flow MRI. Despite of the low spatial resolution, MRI was able to correctly determine the flow pattern in the aneurysm. The pre-treatment CFD simulation could be helpful in predicting the outcome of a FD treatment, while a post-interventional MRI could prove the desired treatment effect.
Fil: Frolov, S. V.. Tambov State Technical University; Rusia
Fil: Sindeev, S. V.. Tambov State Technical University; Rusia
Fil: Kirschke, J. S.. Universitat Technical Zu Munich; Alemania
Fil: Arnold, P.. Universitat Technical Zu Munich; Alemania
Fil: Prothmann, S.. Universitat Technical Zu Munich; Alemania
Fil: Liepsch, D.. Munich University of Applied Sciences; Alemania
Fil: Balasso, A.. Ludwig Maximilians Universitat; Alemania
Fil: Potlov, A.. Tambov State Technical University; Rusia
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina
Fil: Kaczmarz, S.. Universitat Technical Zu Munich; Alemania
Materia
CFD
MRI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96558
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96558
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral arteryFrolov, S. V.Sindeev, S. V.Kirschke, J. S.Arnold, P.Prothmann, S.Liepsch, D.Balasso, A.Potlov, A.Larrabide, IgnacioKaczmarz, S.CFDMRIhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Abstract: Flow changes after flow diverter (FD) placement may be assessed by 4D phase-contrast MR-angiography (4D flow MRI) or simulated by computational fluid dynamics (CFD). However, cross-validation and future assessments with both approaches to take advantage of their individual strengths are required. In this study, we investigate the influence of a FD on intra-aneurysmal blood flow using both MRI experiments and CFD simulations. MR measurements were performed in a true-to-scale silicone model of a wide-neck saccular aneurysm of the distal internal carotid artery before and after FD deployment. An experimental setup, including a computer-controlled piston pump, was assembled to simulate pulsatile blood flow. For CFD studies, a virtual stenting technique was used to place a FD into the aneurysm model. Boundary conditions were applied according to MRI-measured flow data. A qualitative and quantitative agreement of velocity fields measured by CFD and MRI both before and after FD placement was demonstrated. The intra-aneurysmal flow reduction in the CFD results was 19%, while a reduction of 23% was measured by 4D flow MRI. Despite of the low spatial resolution, MRI was able to correctly determine the flow pattern in the aneurysm. The pre-treatment CFD simulation could be helpful in predicting the outcome of a FD treatment, while a post-interventional MRI could prove the desired treatment effect.Fil: Frolov, S. V.. Tambov State Technical University; RusiaFil: Sindeev, S. V.. Tambov State Technical University; RusiaFil: Kirschke, J. S.. Universitat Technical Zu Munich; AlemaniaFil: Arnold, P.. Universitat Technical Zu Munich; AlemaniaFil: Prothmann, S.. Universitat Technical Zu Munich; AlemaniaFil: Liepsch, D.. Munich University of Applied Sciences; AlemaniaFil: Balasso, A.. Ludwig Maximilians Universitat; AlemaniaFil: Potlov, A.. Tambov State Technical University; RusiaFil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; ArgentinaFil: Kaczmarz, S.. Universitat Technical Zu Munich; AlemaniaSpringer2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96558Frolov, S. V.; Sindeev, S. V.; Kirschke, J. S.; Arnold, P.; Prothmann, S.; et al.; CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery; Springer; Experiments In Fluids; 59; 11; 11-20180723-4864CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00348-018-2635-8info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00348-018-2635-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:03Zoai:ri.conicet.gov.ar:11336/96558instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:03.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
title CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
spellingShingle CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
Frolov, S. V.
CFD
MRI
title_short CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
title_full CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
title_fullStr CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
title_full_unstemmed CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
title_sort CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery
dc.creator.none.fl_str_mv Frolov, S. V.
Sindeev, S. V.
Kirschke, J. S.
Arnold, P.
Prothmann, S.
Liepsch, D.
Balasso, A.
Potlov, A.
Larrabide, Ignacio
Kaczmarz, S.
author Frolov, S. V.
author_facet Frolov, S. V.
Sindeev, S. V.
Kirschke, J. S.
Arnold, P.
Prothmann, S.
Liepsch, D.
Balasso, A.
Potlov, A.
Larrabide, Ignacio
Kaczmarz, S.
author_role author
author2 Sindeev, S. V.
Kirschke, J. S.
Arnold, P.
Prothmann, S.
Liepsch, D.
Balasso, A.
Potlov, A.
Larrabide, Ignacio
Kaczmarz, S.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CFD
MRI
topic CFD
MRI
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Abstract: Flow changes after flow diverter (FD) placement may be assessed by 4D phase-contrast MR-angiography (4D flow MRI) or simulated by computational fluid dynamics (CFD). However, cross-validation and future assessments with both approaches to take advantage of their individual strengths are required. In this study, we investigate the influence of a FD on intra-aneurysmal blood flow using both MRI experiments and CFD simulations. MR measurements were performed in a true-to-scale silicone model of a wide-neck saccular aneurysm of the distal internal carotid artery before and after FD deployment. An experimental setup, including a computer-controlled piston pump, was assembled to simulate pulsatile blood flow. For CFD studies, a virtual stenting technique was used to place a FD into the aneurysm model. Boundary conditions were applied according to MRI-measured flow data. A qualitative and quantitative agreement of velocity fields measured by CFD and MRI both before and after FD placement was demonstrated. The intra-aneurysmal flow reduction in the CFD results was 19%, while a reduction of 23% was measured by 4D flow MRI. Despite of the low spatial resolution, MRI was able to correctly determine the flow pattern in the aneurysm. The pre-treatment CFD simulation could be helpful in predicting the outcome of a FD treatment, while a post-interventional MRI could prove the desired treatment effect.
Fil: Frolov, S. V.. Tambov State Technical University; Rusia
Fil: Sindeev, S. V.. Tambov State Technical University; Rusia
Fil: Kirschke, J. S.. Universitat Technical Zu Munich; Alemania
Fil: Arnold, P.. Universitat Technical Zu Munich; Alemania
Fil: Prothmann, S.. Universitat Technical Zu Munich; Alemania
Fil: Liepsch, D.. Munich University of Applied Sciences; Alemania
Fil: Balasso, A.. Ludwig Maximilians Universitat; Alemania
Fil: Potlov, A.. Tambov State Technical University; Rusia
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina
Fil: Kaczmarz, S.. Universitat Technical Zu Munich; Alemania
description Abstract: Flow changes after flow diverter (FD) placement may be assessed by 4D phase-contrast MR-angiography (4D flow MRI) or simulated by computational fluid dynamics (CFD). However, cross-validation and future assessments with both approaches to take advantage of their individual strengths are required. In this study, we investigate the influence of a FD on intra-aneurysmal blood flow using both MRI experiments and CFD simulations. MR measurements were performed in a true-to-scale silicone model of a wide-neck saccular aneurysm of the distal internal carotid artery before and after FD deployment. An experimental setup, including a computer-controlled piston pump, was assembled to simulate pulsatile blood flow. For CFD studies, a virtual stenting technique was used to place a FD into the aneurysm model. Boundary conditions were applied according to MRI-measured flow data. A qualitative and quantitative agreement of velocity fields measured by CFD and MRI both before and after FD placement was demonstrated. The intra-aneurysmal flow reduction in the CFD results was 19%, while a reduction of 23% was measured by 4D flow MRI. Despite of the low spatial resolution, MRI was able to correctly determine the flow pattern in the aneurysm. The pre-treatment CFD simulation could be helpful in predicting the outcome of a FD treatment, while a post-interventional MRI could prove the desired treatment effect.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96558
Frolov, S. V.; Sindeev, S. V.; Kirschke, J. S.; Arnold, P.; Prothmann, S.; et al.; CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery; Springer; Experiments In Fluids; 59; 11; 11-2018
0723-4864
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96558
identifier_str_mv Frolov, S. V.; Sindeev, S. V.; Kirschke, J. S.; Arnold, P.; Prothmann, S.; et al.; CFD and MRI studies of hemodynamic changes after flow diverter implantation in a patient-specific model of the cerebral artery; Springer; Experiments In Fluids; 59; 11; 11-2018
0723-4864
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00348-018-2635-8
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00348-018-2635-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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