Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1

Autores
Nahmod, Karen Amelia; Geffner, Jorge Raúl; Walther, Thomas
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We read with interest the article from Crowley et al,1 who studied the role of angiotensin II type 1 (AT1) receptors (AT1aR) on immune cells in the pathogenesis of angiotensin II–induced hypertension by generating bone marrow chimeras with wild-type (WT) donors or donors lacking AT1aR. Interestingly, they found that the group of donors lacking AT1aR had more albuminuria and higher expression of a number of inflammatory mediators, including monocyte chemoattractant protein 1 (MCP-1), with persistent infiltration of macrophages in the kidney, concluding that AT1aR on bone marrow–derived cells had protective actions.
Fil: Nahmod, Karen Amelia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Walther, Thomas. University of Hull; Reino Unido
Materia
At1 Receptor
Angiotensin
Mcp-1
Dendritic Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67671
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1Nahmod, Karen AmeliaGeffner, Jorge RaúlWalther, ThomasAt1 ReceptorAngiotensinMcp-1Dendritic Cellshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We read with interest the article from Crowley et al,1 who studied the role of angiotensin II type 1 (AT1) receptors (AT1aR) on immune cells in the pathogenesis of angiotensin II–induced hypertension by generating bone marrow chimeras with wild-type (WT) donors or donors lacking AT1aR. Interestingly, they found that the group of donors lacking AT1aR had more albuminuria and higher expression of a number of inflammatory mediators, including monocyte chemoattractant protein 1 (MCP-1), with persistent infiltration of macrophages in the kidney, concluding that AT1aR on bone marrow–derived cells had protective actions.Fil: Nahmod, Karen Amelia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Walther, Thomas. University of Hull; Reino UnidoLippincott Williams2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67671Nahmod, Karen Amelia; Geffner, Jorge Raúl; Walther, Thomas; Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1; Lippincott Williams; Hypertension; 56; 7-2010; 6-70194-911XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.110.153205info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.110.153205info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:12Zoai:ri.conicet.gov.ar:11336/67671instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:12.897CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
title Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
spellingShingle Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
Nahmod, Karen Amelia
At1 Receptor
Angiotensin
Mcp-1
Dendritic Cells
title_short Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
title_full Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
title_fullStr Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
title_full_unstemmed Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
title_sort Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1
dc.creator.none.fl_str_mv Nahmod, Karen Amelia
Geffner, Jorge Raúl
Walther, Thomas
author Nahmod, Karen Amelia
author_facet Nahmod, Karen Amelia
Geffner, Jorge Raúl
Walther, Thomas
author_role author
author2 Geffner, Jorge Raúl
Walther, Thomas
author2_role author
author
dc.subject.none.fl_str_mv At1 Receptor
Angiotensin
Mcp-1
Dendritic Cells
topic At1 Receptor
Angiotensin
Mcp-1
Dendritic Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We read with interest the article from Crowley et al,1 who studied the role of angiotensin II type 1 (AT1) receptors (AT1aR) on immune cells in the pathogenesis of angiotensin II–induced hypertension by generating bone marrow chimeras with wild-type (WT) donors or donors lacking AT1aR. Interestingly, they found that the group of donors lacking AT1aR had more albuminuria and higher expression of a number of inflammatory mediators, including monocyte chemoattractant protein 1 (MCP-1), with persistent infiltration of macrophages in the kidney, concluding that AT1aR on bone marrow–derived cells had protective actions.
Fil: Nahmod, Karen Amelia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Walther, Thomas. University of Hull; Reino Unido
description We read with interest the article from Crowley et al,1 who studied the role of angiotensin II type 1 (AT1) receptors (AT1aR) on immune cells in the pathogenesis of angiotensin II–induced hypertension by generating bone marrow chimeras with wild-type (WT) donors or donors lacking AT1aR. Interestingly, they found that the group of donors lacking AT1aR had more albuminuria and higher expression of a number of inflammatory mediators, including monocyte chemoattractant protein 1 (MCP-1), with persistent infiltration of macrophages in the kidney, concluding that AT1aR on bone marrow–derived cells had protective actions.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67671
Nahmod, Karen Amelia; Geffner, Jorge Raúl; Walther, Thomas; Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1; Lippincott Williams; Hypertension; 56; 7-2010; 6-7
0194-911X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67671
identifier_str_mv Nahmod, Karen Amelia; Geffner, Jorge Raúl; Walther, Thomas; Angiotensin II type 1a-deficient bone marrow-derived dendritic cells produce higher levels of monocyte chemoattractant protein 1; Lippincott Williams; Hypertension; 56; 7-2010; 6-7
0194-911X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.110.153205
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.110.153205
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268842159505408
score 13.13397

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