Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
- Autores
- Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; Günther, S.; ter Meulen, J.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.
Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; Nigeria
Fil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: ter Meulen, J.. Philipps University Marburg; Alemania - Materia
-
Arenavirus
Viral Hemorrhagic Fever
Lassa Virus
Junin Virus
Vaccine
Antiviral - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/47954
Ver los metadatos del registro completo
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Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gapsKerber, R.Reindl, S.Romanowski, VictorGomez, Ricardo MartinOgbaini Emovon, E.Günther, S.ter Meulen, J.ArenavirusViral Hemorrhagic FeverLassa VirusJunin VirusVaccineAntiviralhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; NigeriaFil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: ter Meulen, J.. Philipps University Marburg; AlemaniaElsevier Science2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47954Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-1271386-6532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.12.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653214004661info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:28Zoai:ri.conicet.gov.ar:11336/47954instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:29.26CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
title |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
spellingShingle |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps Kerber, R. Arenavirus Viral Hemorrhagic Fever Lassa Virus Junin Virus Vaccine Antiviral |
title_short |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
title_full |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
title_fullStr |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
title_full_unstemmed |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
title_sort |
Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps |
dc.creator.none.fl_str_mv |
Kerber, R. Reindl, S. Romanowski, Victor Gomez, Ricardo Martin Ogbaini Emovon, E. Günther, S. ter Meulen, J. |
author |
Kerber, R. |
author_facet |
Kerber, R. Reindl, S. Romanowski, Victor Gomez, Ricardo Martin Ogbaini Emovon, E. Günther, S. ter Meulen, J. |
author_role |
author |
author2 |
Reindl, S. Romanowski, Victor Gomez, Ricardo Martin Ogbaini Emovon, E. Günther, S. ter Meulen, J. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Arenavirus Viral Hemorrhagic Fever Lassa Virus Junin Virus Vaccine Antiviral |
topic |
Arenavirus Viral Hemorrhagic Fever Lassa Virus Junin Virus Vaccine Antiviral |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research. Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; Alemania Fil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania Fil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina Fil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; Nigeria Fil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania Fil: ter Meulen, J.. Philipps University Marburg; Alemania |
description |
Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/47954 Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127 1386-6532 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/47954 |
identifier_str_mv |
Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127 1386-6532 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.12.004 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653214004661 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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