Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps

Autores
Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; Günther, S.; ter Meulen, J.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.
Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; Nigeria
Fil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: ter Meulen, J.. Philipps University Marburg; Alemania
Materia
Arenavirus
Viral Hemorrhagic Fever
Lassa Virus
Junin Virus
Vaccine
Antiviral
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47954
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47954
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gapsKerber, R.Reindl, S.Romanowski, VictorGomez, Ricardo MartinOgbaini Emovon, E.Günther, S.ter Meulen, J.ArenavirusViral Hemorrhagic FeverLassa VirusJunin VirusVaccineAntiviralhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; ArgentinaFil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; NigeriaFil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; AlemaniaFil: ter Meulen, J.. Philipps University Marburg; AlemaniaElsevier Science2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47954Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-1271386-6532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.12.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653214004661info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:36Zoai:ri.conicet.gov.ar:11336/47954instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:36.958CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
title Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
spellingShingle Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
Kerber, R.
Arenavirus
Viral Hemorrhagic Fever
Lassa Virus
Junin Virus
Vaccine
Antiviral
title_short Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
title_full Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
title_fullStr Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
title_full_unstemmed Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
title_sort Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps
dc.creator.none.fl_str_mv Kerber, R.
Reindl, S.
Romanowski, Victor
Gomez, Ricardo Martin
Ogbaini Emovon, E.
Günther, S.
ter Meulen, J.
author Kerber, R.
author_facet Kerber, R.
Reindl, S.
Romanowski, Victor
Gomez, Ricardo Martin
Ogbaini Emovon, E.
Günther, S.
ter Meulen, J.
author_role author
author2 Reindl, S.
Romanowski, Victor
Gomez, Ricardo Martin
Ogbaini Emovon, E.
Günther, S.
ter Meulen, J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Arenavirus
Viral Hemorrhagic Fever
Lassa Virus
Junin Virus
Vaccine
Antiviral
topic Arenavirus
Viral Hemorrhagic Fever
Lassa Virus
Junin Virus
Vaccine
Antiviral
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.
Fil: Kerber, R.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Reindl, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: Romanowski, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Gomez, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Ogbaini Emovon, E.. Irrua Specialist Teaching Hospital; Nigeria
Fil: Günther, S.. Bernhard Nocht Institute for Tropical Medicine; Alemania
Fil: ter Meulen, J.. Philipps University Marburg; Alemania
description Significant progress has been made in the past 10 years in unraveling the molecular biology of highly pathogenic arenaviruses that are endemic in several West African countries (Lassa fever virus) and in some regions of South America (Argentine and Bolivian hemorrhagic fever viruses). While this has resulted in proof-of-concept studies of novel vaccine candidates in non-human primates and in the discovery of several novel antiviral small molecule drug candidates, none of them has been tested in the clinic to date. The recent Ebola outbreak in West Africa has demonstrated very clearly that there is an urgent need to develop the prophylactic and therapeutic armamentarium against viral hemorrhagic fever viruses as part of a global preparedness for future epidemics. As it pertains to this goal, the present article summarizes the current knowledge of highly pathogenic arenaviruses and identifies opportunities for translational research.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47954
Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127
1386-6532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47954
identifier_str_mv Kerber, R.; Reindl, S.; Romanowski, Victor; Gomez, Ricardo Martin; Ogbaini Emovon, E.; et al.; Research efforts to control highly pathogenic arenaviruses: A summary of the progress and gaps; Elsevier Science; Journal of Clinical Virology; 64; 3-2015; 120-127
1386-6532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2014.12.004
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653214004661
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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