Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

Autores
Della Felice, Franco; Sarotti, Ariel Marcelo; Krische, Michael J.; Pilli, Ronaldo A.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.
Fil: Della Felice, Franco. Universidade Estadual de Campinas; Brasil. University of Texas at Austin; Estados Unidos
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Krische, Michael J.. University of Texas at Austin; Estados Unidos
Fil: Pilli, Ronaldo A.. Universidade Estadual de Campinas; Brasil
Materia
TOTAL SYNTHESIS
STRUCTURAL VALIDATION
PHOSDIECIN A
ASYMMETRIC CARBONYL REDUCTIVE COUPLING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117465
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive CouplingDella Felice, FrancoSarotti, Ariel MarceloKrische, Michael J.Pilli, Ronaldo A.TOTAL SYNTHESISSTRUCTURAL VALIDATIONPHOSDIECIN AASYMMETRIC CARBONYL REDUCTIVE COUPLINGhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.Fil: Della Felice, Franco. Universidade Estadual de Campinas; Brasil. University of Texas at Austin; Estados UnidosFil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Krische, Michael J.. University of Texas at Austin; Estados UnidosFil: Pilli, Ronaldo A.. Universidade Estadual de Campinas; BrasilAmerican Chemical Society2019-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117465Della Felice, Franco; Sarotti, Ariel Marcelo; Krische, Michael J.; Pilli, Ronaldo A.; Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling; American Chemical Society; Journal of the American Chemical Society; 141; 35; 21-9-2019; 13778-137820002-7863CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1021/jacs.9b07512info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737538/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:47:07Zoai:ri.conicet.gov.ar:11336/117465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:47:07.548CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
title Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
spellingShingle Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
Della Felice, Franco
TOTAL SYNTHESIS
STRUCTURAL VALIDATION
PHOSDIECIN A
ASYMMETRIC CARBONYL REDUCTIVE COUPLING
title_short Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
title_full Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
title_fullStr Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
title_full_unstemmed Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
title_sort Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
dc.creator.none.fl_str_mv Della Felice, Franco
Sarotti, Ariel Marcelo
Krische, Michael J.
Pilli, Ronaldo A.
author Della Felice, Franco
author_facet Della Felice, Franco
Sarotti, Ariel Marcelo
Krische, Michael J.
Pilli, Ronaldo A.
author_role author
author2 Sarotti, Ariel Marcelo
Krische, Michael J.
Pilli, Ronaldo A.
author2_role author
author
author
dc.subject.none.fl_str_mv TOTAL SYNTHESIS
STRUCTURAL VALIDATION
PHOSDIECIN A
ASYMMETRIC CARBONYL REDUCTIVE COUPLING
topic TOTAL SYNTHESIS
STRUCTURAL VALIDATION
PHOSDIECIN A
ASYMMETRIC CARBONYL REDUCTIVE COUPLING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.
Fil: Della Felice, Franco. Universidade Estadual de Campinas; Brasil. University of Texas at Austin; Estados Unidos
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Krische, Michael J.. University of Texas at Austin; Estados Unidos
Fil: Pilli, Ronaldo A.. Universidade Estadual de Campinas; Brasil
description The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117465
Della Felice, Franco; Sarotti, Ariel Marcelo; Krische, Michael J.; Pilli, Ronaldo A.; Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling; American Chemical Society; Journal of the American Chemical Society; 141; 35; 21-9-2019; 13778-13782
0002-7863
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117465
identifier_str_mv Della Felice, Franco; Sarotti, Ariel Marcelo; Krische, Michael J.; Pilli, Ronaldo A.; Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling; American Chemical Society; Journal of the American Chemical Society; 141; 35; 21-9-2019; 13778-13782
0002-7863
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1021/jacs.9b07512
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737538/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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