1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.

Autores
van Uden, M. J.; Bonetto, Fernando Jose; ter Voert, E.; Orzada, S.; de Vries, J.; van Laarhoven, H.; Heerschap, A.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
RF excitation and reception offers advantages for absolute quantification of metabolites, drugs and cells in vivo. Capecitabine is a drug taken orally for treatment of liver metastasis in colorectal cancer. It is a prodrug that is preferentially converted to active metabolites in tumor tissue and further catabolized in the liver. Since capecitabine and its metabolites contain a fluorine atom it is possible to assess their distribution in healthy liver tissue and in liver metastases by 19F MRS. Monitoring and quantification of cells, applied therapeutically, in vivo is of major importance to estimate treatment efficacy. It has been demonstrated that combined 1H and 19F MRI allows for positive localization of cells and their quantification directly from image data, in a noninvasive way, without using radio-isotopes. Here we present a new coil setup that is capable of creating a homogeneous transmit RF-field for 19F and 1H in combination with dedicated receive coils for lymph nodes and for the liver to enable drug and cellular monitoring.
Fil: van Uden, M. J.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: ter Voert, E.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Orzada, S.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: de Vries, J.. Nijmegen Center For Molecular Life Sciences; Países Bajos
Fil: van Laarhoven, H.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Heerschap, A.. Radboud University Nijmegen Medical Center; Países Bajos
Materia
19F MRI
Coils for magnetic homogeneity
Cell tracking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103382
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/103382
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.van Uden, M. J.Bonetto, Fernando Joseter Voert, E.Orzada, S.de Vries, J.van Laarhoven, H.Heerschap, A.19F MRICoils for magnetic homogeneityCell trackinghttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2RF excitation and reception offers advantages for absolute quantification of metabolites, drugs and cells in vivo. Capecitabine is a drug taken orally for treatment of liver metastasis in colorectal cancer. It is a prodrug that is preferentially converted to active metabolites in tumor tissue and further catabolized in the liver. Since capecitabine and its metabolites contain a fluorine atom it is possible to assess their distribution in healthy liver tissue and in liver metastases by 19F MRS. Monitoring and quantification of cells, applied therapeutically, in vivo is of major importance to estimate treatment efficacy. It has been demonstrated that combined 1H and 19F MRI allows for positive localization of cells and their quantification directly from image data, in a noninvasive way, without using radio-isotopes. Here we present a new coil setup that is capable of creating a homogeneous transmit RF-field for 19F and 1H in combination with dedicated receive coils for lymph nodes and for the liver to enable drug and cellular monitoring.Fil: van Uden, M. J.. Radboud University Nijmegen Medical Center; Países BajosFil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: ter Voert, E.. Radboud University Nijmegen Medical Center; Países BajosFil: Orzada, S.. Radboud University Nijmegen Medical Center; Países BajosFil: de Vries, J.. Nijmegen Center For Molecular Life Sciences; Países BajosFil: van Laarhoven, H.. Radboud University Nijmegen Medical Center; Países BajosFil: Heerschap, A.. Radboud University Nijmegen Medical Center; Países BajosJohn Wiley & Sons Inc2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103382van Uden, M. J.; Bonetto, Fernando Jose; ter Voert, E.; Orzada, S.; de Vries, J.; et al.; 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.; John Wiley & Sons Inc; Proceedings of the International Society for Magnetic Resonance in Medicine; 19; 5-2011; 1901-19011065-9889CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:55Zoai:ri.conicet.gov.ar:11336/103382instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:55.964CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
title 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
spellingShingle 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
van Uden, M. J.
19F MRI
Coils for magnetic homogeneity
Cell tracking
title_short 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
title_full 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
title_fullStr 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
title_full_unstemmed 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
title_sort 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.
dc.creator.none.fl_str_mv van Uden, M. J.
Bonetto, Fernando Jose
ter Voert, E.
Orzada, S.
de Vries, J.
van Laarhoven, H.
Heerschap, A.
author van Uden, M. J.
author_facet van Uden, M. J.
Bonetto, Fernando Jose
ter Voert, E.
Orzada, S.
de Vries, J.
van Laarhoven, H.
Heerschap, A.
author_role author
author2 Bonetto, Fernando Jose
ter Voert, E.
Orzada, S.
de Vries, J.
van Laarhoven, H.
Heerschap, A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv 19F MRI
Coils for magnetic homogeneity
Cell tracking
topic 19F MRI
Coils for magnetic homogeneity
Cell tracking
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv RF excitation and reception offers advantages for absolute quantification of metabolites, drugs and cells in vivo. Capecitabine is a drug taken orally for treatment of liver metastasis in colorectal cancer. It is a prodrug that is preferentially converted to active metabolites in tumor tissue and further catabolized in the liver. Since capecitabine and its metabolites contain a fluorine atom it is possible to assess their distribution in healthy liver tissue and in liver metastases by 19F MRS. Monitoring and quantification of cells, applied therapeutically, in vivo is of major importance to estimate treatment efficacy. It has been demonstrated that combined 1H and 19F MRI allows for positive localization of cells and their quantification directly from image data, in a noninvasive way, without using radio-isotopes. Here we present a new coil setup that is capable of creating a homogeneous transmit RF-field for 19F and 1H in combination with dedicated receive coils for lymph nodes and for the liver to enable drug and cellular monitoring.
Fil: van Uden, M. J.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: ter Voert, E.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Orzada, S.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: de Vries, J.. Nijmegen Center For Molecular Life Sciences; Países Bajos
Fil: van Laarhoven, H.. Radboud University Nijmegen Medical Center; Países Bajos
Fil: Heerschap, A.. Radboud University Nijmegen Medical Center; Países Bajos
description RF excitation and reception offers advantages for absolute quantification of metabolites, drugs and cells in vivo. Capecitabine is a drug taken orally for treatment of liver metastasis in colorectal cancer. It is a prodrug that is preferentially converted to active metabolites in tumor tissue and further catabolized in the liver. Since capecitabine and its metabolites contain a fluorine atom it is possible to assess their distribution in healthy liver tissue and in liver metastases by 19F MRS. Monitoring and quantification of cells, applied therapeutically, in vivo is of major importance to estimate treatment efficacy. It has been demonstrated that combined 1H and 19F MRI allows for positive localization of cells and their quantification directly from image data, in a noninvasive way, without using radio-isotopes. Here we present a new coil setup that is capable of creating a homogeneous transmit RF-field for 19F and 1H in combination with dedicated receive coils for lymph nodes and for the liver to enable drug and cellular monitoring.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103382
van Uden, M. J.; Bonetto, Fernando Jose; ter Voert, E.; Orzada, S.; de Vries, J.; et al.; 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.; John Wiley & Sons Inc; Proceedings of the International Society for Magnetic Resonance in Medicine; 19; 5-2011; 1901-1901
1065-9889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103382
identifier_str_mv van Uden, M. J.; Bonetto, Fernando Jose; ter Voert, E.; Orzada, S.; de Vries, J.; et al.; 1H/19F large coverage homogeneous transmit coil with dedicated multi-element receive coils.; John Wiley & Sons Inc; Proceedings of the International Society for Magnetic Resonance in Medicine; 19; 5-2011; 1901-1901
1065-9889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613568706641920
score 13.070432

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